Plasminogen activator inhibitor-1 and tumour growth, invasion, and metastasis

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

The microenvironment of the tumour–host interface

2001 • 2,307 citations

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Biology and biochemistry of proteinases in tumor invasion

1993 • 1,264 citations

Structure of a serpin–protease complex shows inhibition by deformation

2000 • 1,054 citations

The plasminogen activation system in tumor growth, invasion, and metastasis

2000 • 930 citations

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction

1996 • 772 citations

Role of the Matrix Metalloproteinase and Plasminogen Activator–Plasmin Systems in Angiogenesis

2001 • 754 citations

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization

1998 • 683 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function

2000 • 556 citations

Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells

2000 • 555 citations

Structural basis of latency in plasminogen activator inhibitor-1

1992 • 552 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

The origin of the myofibroblasts in breast cancer. Recapitulation of tumor environment in culture unravels diversity and implicates converted fibroblasts and recruited smooth muscle cells.

1995 • 425 citations

New insights into the role of extracellular matrix during tumor onset and progression

2002 • 415 citations

Plasminogen activator inhibitors: hormonally regulated serpins

1990 • 409 citations

EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma

2002 • 386 citations

Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth

2000 • 379 citations

Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1.

1990 • 374 citations

The plasminogen activator system: biology and regulation

1999 • 373 citations

Proteases as prognostic markers in cancer.

1996 • 319 citations

The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin

2001 • 311 citations

Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes

1997 • 304 citations

Urokinase-plasminogen activator, a new and independent prognostic marker in breast cancer.

1990 • 294 citations

Plasminogen activator inhibitor-1 detaches cells from extracellular matrices by inactivating integrins

2003 • 287 citations

The pro‐ or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent

2002 • 277 citations

Plasminogen Activator Inhibitor-1 Regulates Tumor Growth and Angiogenesis

2001 • 264 citations

The human myoepithelial cell is a natural tumor suppressor.

1997 • 247 citations

How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration

2003 • 247 citations

uPA, uPAR, PAI-I: Key intersection of proteolytic, adhesive and chemotacfic highways?

1997 • 246 citations

Role of Vitronectin and Its Receptors in Haemostasis and Vascular Remodeling

1998 • 237 citations

Clinical Relevance of the Urokinase-Type and Tissue-Type Plasminogen Activators and of Their Type 1 Inhibitor in Breast Cancer

1991 • 236 citations

Plasminogen Activator Inhibitor-1 Represses Integrin- and Vitronectin-Mediated Cell Migration Independently of Its Function as an Inhibitor of Plasminogen Activation

1997 • 234 citations

Serpinopathies and the conformational dementias

2002 • 234 citations

The low-density lipoprotein receptor gene family: a cellular Swiss army knife?

2002 • 224 citations

Urokinase Plasminogen Activator and Its Inhibitor, PAI-1, as Prognostic Markers in Breast Cancer: From Pilot to Level 1 Evidence Studies

2002 • 223 citations

alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor.

1995 • 194 citations

Urokinase-type plasminogen activator (u-PA) antigen is a predictor of early relapse in breast cancer

1990 • 189 citations

In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis.

1992 • 187 citations

Receptors of the low density lipoprotein (LDL) receptor family in man. Multiple functions of the large family members via interaction with complex ligands.

1998 • 183 citations

The multiple roles of tumour stroma

1997 • 174 citations

Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin.

2001 • 170 citations

Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes

1993 • 169 citations

Expression of plasminogen activator inhibitor type 1 by human prostate carcinoma cells inhibits primary tumor growth, tumor-associated angiogenesis, and metastasis to lung and liver in an athymic mouse model.

1995 • 160 citations

Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice

1998 • 157 citations

Serpin tertiary structure transformation

1991 • 155 citations

Structure-Function Relationships in the Interaction Between the Urokinase- Type Plasminogen Activator and Its Receptor

2003 • 155 citations

Regulation of cell adhesion by PAI‐1

1999 • 154 citations

The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion

1999 • 154 citations

Reduced metastasis of transgenic mammary cancer in urokinase-deficient mice

2004 • 150 citations

Differential Functions of Members of the Low Density Lipoprotein Receptor Family Suggested by Their Distinct Endocytosis Rates

2001 • 150 citations

Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer

2004 • 148 citations

Mutant mice with scrambled brains: understanding the signaling pathways that control cell positioning in the CNS

1999 • 147 citations

Co‐expression of urokinase, urokinase receptor and PAI‐1 is necessary for optimum invasiveness of cultured lung cancer cells

1995 • 146 citations

A Urokinase Receptor-associated Protein with Specific Collagen Binding Properties

2000 • 143 citations

Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor.

1994 • 135 citations

SERPINE2 (protease nexin I) promotes extracellular matrix production and local invasion of pancreatic tumors in vivo.

2003 • 131 citations

A mutant, noninhibitory plasminogen activator inhibitor type 1 decreases matrix accumulation in experimental glomerulonephritis

2003 • 129 citations

Localization of vitronectin binding domain in plasminogen activator inhibitor-1.

1994 • 126 citations

Induction of primary cutaneous melanocytic neoplasms in urokinase-type plasminogen activator (uPA)-deficient and wild-type mice: cellular blue nevi invade but do not progress to malignant melanoma in uPA-deficient animals.

1996 • 125 citations

Plasminogen Activator Inhibitor-1 Contains a Cryptic High Affinity Binding Site for the Low Density Lipoprotein Receptor-related Protein

1998 • 124 citations

Plasminogen activator inhibitor‐1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin

2001 • 124 citations

True

2000 • 123 citations

Role of plasminogen activator-plasmin system in tumor angiogenesis

2003 • 121 citations

Growth and Dissemination of Lewis Lung Carcinoma in Plasminogen-Deficient Mice

1997 • 113 citations

Very Low Density Lipoprotein Receptor Binds and Mediates Endocytosis of Urokinase-type Plasminogen Activator-Type-1 Plasminogen Activator Inhibitor Complex

1995 • 112 citations

Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells.

1990 • 111 citations

Messenger RNA for urokinase plasminogen activator is expressed in myofibroblasts adjacent to cancer cells in human breast cancer.

1996 • 110 citations

The Urokinase Plasminogen Activator Receptor in the Regulation of the Actin Cytoskeleton and Cell Motility

2002 • 107 citations

Inhibitors of urokinase reduce size of prostate cancer xenografts in severe combined immunodeficient mice.

1997 • 102 citations

Plasminogen Activator Inhibitor 1 Functions as a Urokinase Response Modifier at the Level of Cell Signaling and Thereby Promotes Mcf-7 Cell Growth

2001 • 101 citations

Peptide-mediated inactivation of recombinant and platelet plasminogen activator inhibitor-1 in vitro.

1995 • 100 citations

Contrasting Effects of Plasminogen Activators, Urokinase Receptor, and LDL Receptor–Related Protein on Smooth Muscle Cell Migration and Invasion

1996 • 100 citations

Serpins and other covalent protease inhibitors

2001 • 100 citations

Conformational changes in serpins: I. the native and cleaved conformations of α 1 -antitrypsin 1 1Edited by J. M. Thornton

2000 • 98 citations

Influence of plasminogen activator inhibitor type 1 on choroidal neovascularization

2001 • 96 citations

Lack of plasminogen activator inhibitor-1 effect in a transgenic mouse model of metastatic melanoma

1996 • 94 citations

Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide

1998 • 93 citations

Embryonic Fibroblasts That Are Genetically Deficient in Low Density Lipoprotein Receptor-related Protein Demonstrate Increased Activity of the Urokinase Receptor System and Accelerated Migration on Vitronectin

1997 • 93 citations

Interconversions between active, inert and substrate forms of denatured/refolded type-1 plasminogen activator inhibitor

1993 • 92 citations

Novel low-molecular-weight inhibitor of PAI-1 (XR5118) promotes endogenous fibrinolysis and reduces postthrombolysis thrombus growth in rabbits.

1997 • 91 citations

A substrate‐like form of plasminogen‐activator‐inhibitor type 1

1992 • 90 citations

Role of Myofibroblasts at the Invasion Front

2002 • 89 citations

The structural basis for the pathophysiological relevance of PAI-1 in cardiovascular diseases and the development of potential PAI-1 inhibitors

2004 • 87 citations

Melanoma cell migration on vitronectin: Regulation by components of the plasminogen activation system

1997 • 84 citations

Binding of urokinase-type plasminogen activator–plasminogen activator inhibitor-1 complex to the endocytosis receptors α2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor

1998 • 84 citations

Plasminogen Activator Inhibitor-1 and -3 Increase Cell Adhesion and Motility of MDA-MB-435 Breast Cancer Cells

2002 • 82 citations

Plasminogen activator inhibitor type I stabilizes vitronectin-dependent adhesions in HT-1080 cells.

1990 • 78 citations

Evaluation of a Low Molecular Weight Modulator of Human Plasminogen Activator Inhibitor-1 Activity

1996 • 78 citations

Urokinase Plasminogen Activator Is Localized in Stromal Cells in Ductal Breast Cancer

2001 • 75 citations

The Molecular Basis for Anti-Proteolytic and Non-Proteolytic Functions of Plasminogen Activator Inhibitor Type-1: Roles of the Reactive Centre Loop, the Shutter Region, the Flexible Joint Region and the Small Serpin Fragment

2002 • 74 citations

Polyoma Middle T-induced Vascular Tumor Formation: The Role of the Plasminogen Activator/Plasmin System

1997 • 73 citations

Inhibition of Metastasis of Intraocular Melanomas by Adenovirus-Mediated Gene Transfer of Plasminogen Activator Inhibitor Type 1 (PAI-1) in an Athymic Mouse Model

1997 • 73 citations

GPI-anchored uPAR requires Endo180 for rapid directional sensing during chemotaxis

2003 • 71 citations

The PAI-1/Vitronectin Interaction: Two Cats in a Bag?

1995 • 70 citations

Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice

2003 • 70 citations

Accelerated Conversion of Human Plasminogen Activator Inhibitor-1 to Its Latent Form by Antibody Binding

1999 • 70 citations

The Myofibroblast Is the Predominant Plasminogen Activator Inhibitor-1-Expressing Cell Type in Human Breast Carcinomas

2003 • 70 citations

PAI‐1 inhibits urokinase‐induced chemotaxis by internalizing the urokinase receptor

2001 • 70 citations

Modulation of Plasminogen Activator Inhibitor 1 by Triton X-100 – Identification of Two Consecutive Conformational Transitions

1998 • 70 citations

Type 1 Plasminogen Activator Inhibitor Binds to Fibrin via Vitronectin

2000 • 69 citations

Low Density Lipoprotein (LDL) Receptor-related Protein 1B Impairs Urokinase Receptor Regeneration on the Cell Surface and Inhibits Cell Migration

2002 • 66 citations

Direct evidence of the importance of stromal urokinase plasminogen activator (uPA) in the growth of an experimental human breast cancer using a combined uPA gene-disrupted and immunodeficient xenograft model.

2001 • 65 citations

The Migration of Human Smooth Muscle Cells In Vitro Is Mediated by Plasminogen Activation and Can Be Inhibited by α2-Macroglobulin Receptor Associated Protein

1997 • 64 citations

Identification of the Binding Site for a Low-Molecular-Weight Inhibitor of Plasminogen Activator Inhibitor Type 1 by Site-Directed Mutagenesis

1998 • 63 citations

Enhanced Expression of the LDL Receptor Family Member LR11 Increases Migration of Smooth Muscle Cells In Vitro

2002 • 62 citations

Inhibition of Plasminogen Activator Inhibitor-1 Activity by Two Diketopiperazines, XR330 and XR334 Produced by Streptomyces sp.

1996 • 61 citations

A Regulatory Hydrophobic Area in the Flexible Joint Region of Plasminogen Activator Inhibitor-1, Defined with Fluorescent Activity-neutralizing Ligands

2001 • 60 citations

Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor-1

2001 • 58 citations

Endogenous receptor-bound urokinase mediates tissue invasion of the human lung carcinoma cell lines A549 and Calu-1.

1992 • 55 citations

The plasminogen-plasminogen activator (PA) system in neuroblastoma: role of PA inhibitor-1 in metastasis.

1999 • 54 citations

The vitronectin binding area of plasminogen activator inhibitor‐1, mapped by mutagenesis and protection against an inactivating organochemical ligand

2002 • 52 citations

Determination of the vitronectin binding site on plasminogen activator inhibitor 1 (PAI‐1)

1994 • 51 citations

Biochemical importance of glycosylation of plasminogen activator inhibitor-1

2003 • 51 citations

Plasminogen activator inhibitor-1 as a measure of vascular remodelling in breast cancer

2001 • 51 citations

Functional domains of the very low density lipoprotein receptor: molecular analysis of ligand binding and acid-dependent ligand dissociation mechanisms

1999 • 49 citations

Epitope mapping for four monoclonal antibodies against human plasminogen activator inhibitor type‐1

2001 • 48 citations

Interaction of plasminogen activator inhibitor type‐1 (PAI‐1) with vitronectin

2002 • 47 citations

Plasminogen activator inhibitor 1 contains a cryptic high affinity receptor binding site that is exposed upon complex formation with tissue-type plasminogen activator.

1998 • 46 citations

The pro-urokinase plasminogen-activation system in the presence of serpin-type inhibitors and the urokinase receptor: rescue of activity through reciprocal pro-enzyme activation

2003 • 44 citations

Vitronectin in human breast carcinomas

2003 • 44 citations

Human Endothelial Cell Migration Is Stimulated by Urokinase Plasminogen Activator:Plasminogen Activator Inhibitor 1 Complex Released from Endometrial Stromal Cells Stimulated with Transforming Growth Factor β1; Possible Mechanism for Paracrine Stimulation of Endometrial Angiogenesis1

1998 • 43 citations

Plasminogen Activator Inhibitor-1 Overexpression in Nonproliferative Diabetic Retinopathy

1996 • 41 citations

The Low Density Lipoprotein Receptor-related Protein/α2-Macroglobulin Receptor Regulates Cell Surface Plasminogen Activator Activity on Human Trophoblast Cells

1998 • 40 citations

Biochemical mechanism of action of a diketopiperazine inactivator of plasminogen activator inhibitor-1

2003 • 40 citations

The Distal Hinge of the Reactive Site Loop and Its Proximity

2001 • 37 citations

Independent prognostic value of angiogenesis and the level of plasminogen activator inhibitor type 1 in breast cancer patients

2003 • 36 citations

Localization of a Vitronectin Binding Region of Plasminogen Activator Inhibitor-1

1995 • 36 citations

Both u‐PA inhibition and vitronectin binding by plasminogen activator inhibitor 1 regulate HT1080 fibrosarcoma cell metastasis

2002 • 35 citations

Urokinase Plasminogen Activator as a Predictor of Aggressive Disease in Breast Cancer

1996 • 34 citations

Analysis of a two-domain binding site for the urokinase-type plasminogen activator‒plasminogen activator inhibitor-1 complex in low-density-lipoprotein-receptor-related protein

2001 • 34 citations

Characterization and Comparative Evaluation of a Novel PAI-1 Inhibitor

2002 • 33 citations

Novel Inhibitors of Plasminogen Activator Inhibitor-1: Development of New Templates From Diketopiperazines

2002 • 33 citations

Role of activated protein C in facilitating basement membrane invasion by tumor cells.

1994 • 31 citations

Sideroxylonal C, a New Inhibitor of Human Plasminogen Activator Inhibitor Type-1, from the Flowers of Eucalyptus albens

1999 • 31 citations

New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA–PAI-1 complex formation

2003 • 29 citations

Mutational and immunochemical analysis of plasminogen activator inhibitor 1.

1990 • 29 citations

Plasminogen activator inhibitor-1 polymers, induced by inactivating amphipathic organochemical ligands

2003 • 28 citations

Ligand Binding Properties of the Very Low Density Lipoprotein Receptor

1999 • 28 citations

XR5118, a novel modulator of plasminogen activator inhibitor-1 (PAI-1), increases endogenous tPA activity in the rat

1997 • 27 citations

Solvent Effects on Activity and Conformation of Plasminogen Activator Inhibitor-1

1999 • 26 citations

Fibrillar Collagen Regulation of Plasminogen Activator Inhibitor-1 Is Involved in Altered Smooth Muscle Cell Migration

2002 • 25 citations

Plasminogen activator inhibitor (PAI)-1 overexpression in retinal microvessels of PAI-1 transgenic mice.

2000 • 25 citations

Construction of a plasminogen activator inhibitor‐1 variant without measurable affinity to vitronectin but otherwise normal

2003 • 25 citations

Vitronectin and Substitution of a β-Strand 5A Lysine Residue Potentiate Activity-neutralization of PA Inhibitor-1 by Monoclonal Antibodies against α-Helix F

2000 • 24 citations

The role of plasminogen activator inhibitor‐1 as inhibitor of platelet and megakaryoblastic cell adhesion

1999 • 24 citations

Selection of peptides that bind to plasminogen activator inhibitor 1 (PAI‐1) using random peptide phage‐display libraries

1998 • 20 citations

Plasminogen activator inhibitor-1 accelerates lung metastasis formation of human fibrosarcoma cells.

1997 • 14 citations

Detergent tween 80 modifies the specific activity of PAI-1

1997 • 13 citations

WAY-140312 reduces plasma PAI-1 while maintaining normal platelet aggregation

2003 • 12 citations

Inhibition of Plasminogen Activator Inhibitor-1 by 11-Keto-9(E),12(E)-octadecadienoic Acid, a Novel Fatty Acid Produced by Trichoderma sp.

1999 • 11 citations

Glycosylation dependent conformational transitions in plasminogen activator inhibitor-1: evidence for the presence of two active conformations

2000 • 10 citations