Type 1 Plasminogen Activator Inhibitor Binds to Fibrin via Vitronectin

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Hemostasis and Thrombosis: Basic Principles and Clinical Practice.

1988 • 1,817 citations

Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin.

1982 • 1,300 citations

Hemostasis and Thrombosis: Basic Principles and Clinical Practice

1994 • 723 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin).

1988 • 484 citations

Differential sensitivity of erythrocyte-rich and platelet-rich arterial thrombi to lysis with recombinant tissue-type plasminogen activator. A possible explanation for resistance to coronary thrombolysis.

1989 • 473 citations

Directed Plasminogen Activation at the Surface of Normal and Malignant Cells

1991 • 291 citations

Inhibition of plasminogen activator inhibitor-1 activity results in promotion of endogenous thrombolysis and inhibition of thrombus extension in models of experimental thrombosis.

1992 • 198 citations

Thrombin Binds to Soluble Fibrin Degradation Products Where it Is Protected From Inhibition by Heparin-Antithrombin but Susceptible to Inactivation by Antithrombin-Independent Inhibitors

1998 • 197 citations

Interaction of Plasminogen Activator Inhibitor (PAI-1) with Vitronectin

1989 • 191 citations

Plasminogen activator inhibitor 1 (PAI) is bound to vitronectin in plasma

1988 • 178 citations

Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin.

1991 • 157 citations

Structure of plasminogen activator inhibitor 1 (PAI-1) and its function in fibrinolysis: an update

1995 • 153 citations

Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms

1994 • 140 citations

The Molecular Weights, Mass Distribution, Chain Composition, and Structure of Soluble Fibrin Degradation Products Released from a Fibrin Clot Perfused with Plasmin

1999 • 133 citations

The Cell Adhesion Domain in Plasma Vitronectin Is Cryptic

1997 • 131 citations

The somatomedin B domain of vitronectin. Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor.

1994 • 126 citations

Localization of vitronectin binding domain in plasminogen activator inhibitor-1.

1994 • 126 citations

Plasminogen Activator Inhibitor-1 Contains a Cryptic High Affinity Binding Site for the Low Density Lipoprotein Receptor-related Protein

1998 • 124 citations

Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin

1997 • 123 citations

Quantification of Plasminogen Activators and Their Inhibitors in the Aortic Vessel Wall in Relation to the Presence and Severity of Atherosclerotic Disease

1995 • 120 citations

Structural requirements for the extracellular interaction of plasminogen activator inhibitor 1 with endothelial cell matrix-associated vitronectin.

1990 • 116 citations

Identification of and partial characterization of platelet vitronectin: evidence for complex formation with platelet-derived plasminogen activator inhibitor-1

1989 • 114 citations

Platelets inhibit fibrinolysis in vitro by both plasminogen activator inhibitor-1-dependent and -independent mechanisms

1994 • 112 citations

The interaction of plasminogen activator inhibitor 1 with plasminogen activators (tissue-type and urokinase-type) and fibrin: localization of interaction sites and physiologic relevance

1991 • 99 citations

Interaction between plasminogen activator inhibitor type 1 (PAI-1) bound to fibrin and either tissue-type plasminogen activator (t-PA) or urokinase-type plasminogen activator (u-PA). Binding of t-PA/PAI-1 complexes to fibrin mediated by both the finger and the kringle-2 domain of t-PA.

1989 • 99 citations

The Amount of Plasminogen, Tissue-Type Plasminogen Activator and Plasminogen Activator Inhibitor Type 1 in Human Thrombi and the Relation to IVVO-TNO Lysibility

1992 • 96 citations

Binding of Type 1 Plasminogen Activator Inhibitor to the Extracellular Matrix of Cultured Bovine Endothelial Cells

1989 • 94 citations

Proteins of the Fibrinolytic System in Human Thrombi

1996 • 90 citations

Variants of human tissue-type plasminogen activator. Fibrin binding, fibrinolytic, and fibrinogenolytic characterization of genetic variants lacking the fibronectin finger-like and/or the epidermal growth factor domains.

1988 • 89 citations

On the target specificity of plasminogen activator inhibitor 1: the role of heparin, vitronectin, and the reactive site

1991 • 82 citations

Monocyte Plasminogen Activator Inhibitor 2 (PAI-2) Inhibits u-PA-mediated Fibrin Clot Lysis and Is Cross-linked to Fibrin

1999 • 77 citations

Two functionally distinct pools of vitronectin (Vn) in the blood circulation: identification of a heparin-binding competent population of Vn within platelet alpha-granules

1996 • 77 citations

Attenuation of thrombolysis by release of plasminogen activator inhibitor type-1 from platelets

1993 • 75 citations

Soluble fibrin degradation products potentiate tissue plasminogen activator-induced fibrinogen proteolysis.

1991 • 72 citations

Tissue-type plasminogen activator (t-PA) : physiological and clinical aspects

1988 • 72 citations

Lysis of Platelet‐rich Thrombi: The Role of PAI–1a

1992 • 67 citations

Type 1 Plasminogen Activator Inhibitor Induces Multimerization of Plasma Vitronectin

1996 • 58 citations

Plasminogen activator inhibitor-1 binds to fibrin and inhibits tissue-type plasminogen activator-mediated fibrin dissolution.

1992 • 57 citations

Determination of the vitronectin binding site on plasminogen activator inhibitor 1 (PAI‐1)

1994 • 51 citations

Native and Multimeric Vitronectin Exhibit Similar Affinity for Heparin

1997 • 42 citations

IL-6 stimulates vitronectin gene expression in vivo.

1995 • 39 citations

Differential mechanisms targeting type 1 plasminogen activator inhibitor and vitronectin into the storage granules of a human megakaryocytic cell line

1996 • 32 citations

The role of plasminogen activator inhibitor‐1 as inhibitor of platelet and megakaryoblastic cell adhesion

1999 • 24 citations

PAI-1 released from cultured human endothelial cells delays fibrinolysis and is incorporated into the developing fibrin clot

1994 • 23 citations

The Significance of Fibrin Binding by Plasminogen Activator Inhibitor 1 for the Mechanism of Tissue-type Plasminogen Activator-mediated Fibrinolysis

1995 • 18 citations

[Tissue-type plasminogen activator (t-PA)].

1987 • 17 citations