Epitope mapping for four monoclonal antibodies against human plasminogen activator inhibitor type‐1

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Structure of a serpin–protease complex shows inhibition by deformation

2000 • 1,054 citations

The plasminogen activation system in tumor growth, invasion, and metastasis

2000 • 930 citations

Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins

1989 • 898 citations

[15] Libraries of peptides and proteins displayed on filamentous phage

1993 • 770 citations

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization

1998 • 683 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants.

1985 • 555 citations

Structural basis of latency in plasminogen activator inhibitor-1

1992 • 552 citations

Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin).

1988 • 484 citations

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1996 • 460 citations

Crystal structure of ovalbumin as a model for the reactive centre of serpins

1990 • 394 citations

Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K‐12

1997 • 341 citations

Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library

1994 • 308 citations

The Urokinase Receptor Is a Major Vitronectin-Binding Protein on Endothelial Cells

1996 • 252 citations

Serpin-Protease Complexes Are Trapped as Stable Acyl-Enzyme Intermediates

1995 • 240 citations

Role of Vitronectin and Its Receptors in Haemostasis and Vascular Remodeling

1998 • 237 citations

Plasminogen Activator Inhibitor-1 Represses Integrin- and Vitronectin-Mediated Cell Migration Independently of Its Function as an Inhibitor of Plasminogen Activation

1997 • 234 citations

High resolution functional analysis of antibody-antigen interactions

1992 • 213 citations

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 Å and full insertion of the reactive center loop into β-sheet A

1999 • 212 citations

Plasminogen activator inhibitor type‐1 : reactive center and amino‐terminal heterogeneity determined by protein and cDNA sequencing

1986 • 207 citations

The Inhibition Mechanism of Serpins

1995 • 176 citations

Serpin tertiary structure transformation

1991 • 155 citations

The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion

1999 • 154 citations

Wild-type α1-antitrypsin is in the canonical inhibitory conformation

1998 • 142 citations

Localization of vitronectin binding domain in plasminogen activator inhibitor-1.

1994 • 126 citations

Characterization of the Binding of Different Conformational Forms of Plasminogen Activator Inhibitor-1 to Vitronectin

1997 • 123 citations

A Fluorescent Probe Study of Plasminogen Activator Inhibitor-1

1995 • 123 citations

Monoclonal Antibodies to Human 54,000 Molecular Weight Plasminogen Activator Inhibitor from Fibrosarcoma Cells - Inhibitor Neutralization and One-Step Affinity Purification

1986 • 120 citations

Filamentous Phage Display of Oligopeptide Libraries

1996 • 120 citations

Immunohistochemical localization of urokinase-type plasminogen activator, type-1 plasminogen-activator inhibitor, urokinase receptor and α2-macroglobulin receptor in human breast carcinomas

1996 • 102 citations

The interaction of plasminogen activator inhibitor 1 with plasminogen activators (tissue-type and urokinase-type) and fibrin: localization of interaction sites and physiologic relevance

1991 • 99 citations

The role of conformational change in serpin structure and function

1993 • 97 citations

Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation

2000 • 93 citations

Structure-function relationships in serpins: current concepts and controversies.

1998 • 86 citations

Melanoma cell migration on vitronectin: Regulation by components of the plasminogen activation system

1997 • 84 citations

Binding of urokinase-type plasminogen activator–plasminogen activator inhibitor-1 complex to the endocytosis receptors α2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor

1998 • 84 citations

Neutralization of plasminogen activator inhibitor-1 inhibitory properties: identification of two different mechanisms

1997 • 77 citations

The PAI-1/Vitronectin Interaction: Two Cats in a Bag?

1995 • 70 citations

The structure of a serpin–protease complex revealed by intramolecular distance measurements using donor–donor energy migration and mapping of interaction sites

2000 • 70 citations

Modulation of Plasminogen Activator Inhibitor 1 by Triton X-100 – Identification of Two Consecutive Conformational Transitions

1998 • 70 citations

The crystal structure of plasminogen activator inhibitor 2 at 2.0 Å resolution: implications for serpin function

1999 • 64 citations

An Ester Bond Linking a Fragment of a Serine Proteinase to Its Serpin Inhibitor

1998 • 64 citations

Type‐1 Plasminogen‐Activator Inhibitor

1997 • 58 citations

Type‐1 inhibitor of plasminogen activators

1991 • 54 citations

Importance of the Hinge Region between α-Helix F and the Main Part of Serpins, Based upon Identification of the Epitope of Plasminogen Activator Inhibitor Type 1 Neutralizing Antibodies

2000 • 54 citations

Determination of the vitronectin binding site on plasminogen activator inhibitor 1 (PAI‐1)

1994 • 51 citations

A serpin‐induced extensive proteolytic susceptibility of urokinase‐type plasminogen activator implicates distortion of the proteinase substrate‐binding pocket and oxyanion hole in the serpin inhibitory mechanism

2001 • 50 citations

Tools for the production and purification of full-length, N- or C-terminal 32P-labeled protein, applied to HIV-1 Gag and Rev

1995 • 38 citations

Localization of a Vitronectin Binding Region of Plasminogen Activator Inhibitor-1

1995 • 36 citations

Epitopes on plasminogen activator inhibitor type-1 important for binding to tissue plasminogen activator

1997 • 26 citations

Vitronectin and Substitution of a β-Strand 5A Lysine Residue Potentiate Activity-neutralization of PA Inhibitor-1 by Monoclonal Antibodies against α-Helix F

2000 • 24 citations

The role of plasminogen activator inhibitor‐1 as inhibitor of platelet and megakaryoblastic cell adhesion

1999 • 24 citations

Functional effects of single amino acid substitutions in the region of Phe113 to Asp138 in the plasminogen activator inhibitor 1 molecule

1998 • 18 citations

Glycerol diversifies phage repertoire selections and lowers non‐specific phage absorption

1998 • 11 citations

Protein movement during complex-formation between tissue plasminogen activator and plasminogen activator inhibitor-1

1999 • 9 citations

Characterization of the interaction of plasminogen activator inhibitor type 1 with vitronectin by surface plasmon resonance

2000 • 8 citations

Melanoma cell migration on vitronectin: Regulation by components of the plasminogen activation system

1997 • 5 citations

Immunohistochemical localization of urokinase‐type plasminogen activator, type‐1 plasminogen‐activator inhibitor, urokinase receptor and α2‐macroglobulin receptor in human breast carcinomas

1996 • 4 citations