Vitronectin in human breast carcinomas

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

The plasminogen activation system in tumor growth, invasion, and metastasis

2000 • 930 citations

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization

1998 • 683 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Pooled Analysis of Prognostic Impact of Urokinase-Type Plasminogen Activator and Its Inhibitor PAI-1 in 8377 Breast Cancer Patients

2002 • 592 citations

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1996 • 460 citations

Serum spreading factor (vitronectin) is present at the cell surface and in tissues.

1983 • 454 citations

Randomized Adjuvant Chemotherapy Trial in High-Risk, Lymph Node-Negative Breast Cancer Patients Identified by Urokinase-Type Plasminogen Activator and Plasminogen Activator Inhibitor Type 1

2001 • 442 citations

Vitronectin and its receptors

1993 • 406 citations

Progress in Hemostasis and Thrombosis.

1974 • 349 citations

The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin

2001 • 311 citations

The pro‐ or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent

2002 • 277 citations

The Urokinase Receptor Is a Major Vitronectin-Binding Protein on Endothelial Cells

1996 • 252 citations

Molecular cloning of S-protein, a link between complement, coagulation and cell-substrate adhesion.

1985 • 241 citations

Role of Vitronectin and Its Receptors in Haemostasis and Vascular Remodeling

1998 • 237 citations

Plasminogen Activator Inhibitor-1 Represses Integrin- and Vitronectin-Mediated Cell Migration Independently of Its Function as an Inhibitor of Plasminogen Activation

1997 • 234 citations

Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice

2000 • 200 citations

Vitronectin is not essential for normal mammalian development and fertility.

1995 • 188 citations

Physicochemical characterization of human S-protein and its function in the blood coagulation system

1985 • 186 citations

Plasminogen Activator Inhibitor-1 and Its Cofactor Vitronectin Stabilize Arterial Thrombi After Vascular Injury in Mice

2001 • 165 citations

The Bases of the Staining of Amyloid Fibers: Their Physico-Chemical Nature and the Mechanism of their Dye-Substrate Interaction

1981 • 162 citations

Multimeric vitronectin. Identification and characterization of conformation-dependent self-association of the adhesive protein.

1993 • 155 citations

Interaction of vitronectin with collagen.

1986 • 146 citations

Persistent complement activation on tumor cells in breast cancer.

1992 • 143 citations

Plasminogen Activator Inhibitor-1 Contains a Cryptic High Affinity Binding Site for the Low Density Lipoprotein Receptor-related Protein

1998 • 124 citations

Vitronectin Inhibits the Thrombotic Response to Arterial Injury in Mice

1999 • 114 citations

Immunohistochemical localization of urokinase-type plasminogen activator, type-1 plasminogen-activator inhibitor, urokinase receptor and α2-macroglobulin receptor in human breast carcinomas

1996 • 102 citations

Type‐1 plasminogen activator inhibitor in human breast carcinomas

1992 • 100 citations

Immunohistochemical Localization of Urokinase- and Tissue-Type Plasminogen Activators in Psoriatic Skin

1987 • 100 citations

Expression and Localization of αv Integrins and Their Ligand Vitronectin in Normal Ovarian Epithelium and in Ovarian Carcinoma

1996 • 96 citations

Immunohistochemical expression of extracellular matrix proteins and adhesion molecules in pancreatic carcinoma.

2001 • 95 citations

Interconversions between active, inert and substrate forms of denatured/refolded type-1 plasminogen activator inhibitor

1993 • 92 citations

Progress in hemostasis and thrombosis

1973 • 88 citations

Binding of urokinase-type plasminogen activator–plasminogen activator inhibitor-1 complex to the endocytosis receptors α2-macroglobulin receptor/low-density lipoprotein receptor-related protein and very-low-density lipoprotein receptor involves basic residues in the inhibitor

1998 • 84 citations

An immunohistochemical study of the extracellular matrix in oral squamous cell carcinoma and its association with invasive and metastatic potential

1994 • 78 citations

Vitronectin deficiency is associated with increased wound fibrinolysis and decreased microvascular angiogenesis in mice

2000 • 75 citations

The Molecular Basis for Anti-Proteolytic and Non-Proteolytic Functions of Plasminogen Activator Inhibitor Type-1: Roles of the Reactive Centre Loop, the Shutter Region, the Flexible Joint Region and the Small Serpin Fragment

2002 • 74 citations

Quantitation of spreading factor in human biologic fluids.

1984 • 71 citations

The PAI-1/Vitronectin Interaction: Two Cats in a Bag?

1995 • 70 citations

Accelerated Conversion of Human Plasminogen Activator Inhibitor-1 to Its Latent Form by Antibody Binding

1999 • 70 citations

Type 1 Plasminogen Activator Inhibitor Binds to Fibrin via Vitronectin

2000 • 69 citations

Plasma vitronectin polymorphism in normal subjects and patients with disseminated intravascular coagulation

1988 • 62 citations

Plasma vitronectin polymorphism in normal subjects and patients with disseminated intravascular coagulation

1988 • 57 citations

Vitronectin binding to urokinase receptor in human breast cancer.

1997 • 55 citations

Altered expression of extracellular matrix molecules and their receptors in chronic pancreatitis and pancreatic adenocarcinoma in comparison with normal pancreas

1995 • 54 citations

Acute Phase Protein α1-Acid Glycoprotein Interacts with Plasminogen Activator Inhibitor Type 1 and Stabilizes Its Inhibitory Activity

2001 • 49 citations

Epitope mapping for four monoclonal antibodies against human plasminogen activator inhibitor type‐1

2001 • 48 citations

Differential expression of extracellular matrix proteins and integrins in hepatocellular carcinoma and chronic liver disease.

1993 • 44 citations

Comparative Distribution of Fibronectin and Vitronectin in Human Breast and Colon Carcinomas: An Immunofluorescence Study

1988 • 41 citations

A novel β-endorphin binding protein

1989 • 40 citations

Localization of plasminogen activators and their inhibitor in squamous cell carcinomas of the head and neck

1997 • 38 citations

Tools for the production and purification of full-length, N- or C-terminal 32P-labeled protein, applied to HIV-1 Gag and Rev

1995 • 38 citations

Breast Carcinoma Epithelial Cells Express a Very Low‐Density Lipoprotein Receptor Variant Lacking the O‐Linked Glycosylation Domain Encoded by Exon 16, But with Full Binding Activity for Serine Proteinase/Serpin Complexes and M_r‐40000 Receptor‐Associated Protein

1997 • 35 citations

The Versatility of Adhesion Receptor Ligands in Haemostasis: Morpho-Regulatory Functions of Vitronectin

1995 • 34 citations

Tissue Vitronectin in Normal Adult Human Dermis Is Non-Covalently Bound to Elastic Tissue

1991 • 24 citations

Mode of tumor invasion in oral squamous cell carcinoma: Improved grading based on immunohistochemical examination of extracellular matrices

1996 • 22 citations