The Low Density Lipoprotein Receptor-related Protein/α2-Macroglobulin Receptor Regulates Cell Surface Plasminogen Activator Activity on Human Trophoblast Cells

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Establishment and Characterization of First Trimester Human Trophoblast Cells with Extended Lifespan

1993 • 979 citations

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.

1988 • 947 citations

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.

1990 • 666 citations

Identification of the urokinase receptor as an adhesion receptor for vitronectin.

1994 • 593 citations

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

1991 • 586 citations

Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor

1991 • 509 citations

The receptor for urokinase type plasminogen activator polarizes expression of the protease to the leading edge of migrating monocytes and promotes degradation of enzyme inhibitor complexes.

1990 • 480 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

The alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein binds and internalizes Pseudomonas exotoxin A.

1992 • 444 citations

Urokinase and urokinase receptor: A paracrine/autocrine system regulating cell migration and invasiveness

1993 • 402 citations

Distribution of the ?2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues

1992 • 385 citations

Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1.

1990 • 374 citations

Autocrine saturation of pro-urokinase receptors on human A431 cells

1986 • 361 citations

Plasminogen Activation Initiated by Single-chain Urokinase-type Plasminogen Activator

1989 • 341 citations

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein.

1992 • 341 citations

Biological and clinical aspects of plasminogen activator inhibitor type 2

1995 • 324 citations

Evidence that the newly cloned low‐density‐lipoprotein receptor related protein (LRP) is the α₂‐macroglobulin receptor

1990 • 320 citations

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator.

1992 • 318 citations

Invasion of the trophoblasts

1992 • 305 citations

Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes

1997 • 304 citations

LDL receptor‐related protein: a multiligand receptor for lipoprotein and proteinase catabolism

1995 • 272 citations

The human alpha 2-macroglobulin receptor: identification of a 420-kD cell surface glycoprotein specific for the activated conformation of alpha 2-macroglobulin.

1990 • 268 citations

Induction of cell migration by pro-urokinase binding to its receptor: possible mechanism for signal transduction in human epithelial cells.

1994 • 266 citations

Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

1992 • 244 citations

Generation and characterization of urokinase receptor-deficient mice.

1996 • 232 citations

The Receptor for Urokinase-type Plasminogen Activator Is Not Essential for Mouse Development or Fertility

1995 • 230 citations

Plasminogen Deficiency Differentially Affects Recruitment of Inflammatory Cell Populations in Mice

1998 • 222 citations

Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy.

1994 • 216 citations

Plasminogen Activation by Receptor-Bound Urokinase

1991 • 214 citations

alpha-2 Macroglobulin receptor/Ldl receptor-related protein(Lrp)-dependent internalization of the urokinase receptor.

1995 • 194 citations

Characteristic's of trophoblast cells migrating from first trimester chorionic villus explants and propagated in culture

1995 • 188 citations

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase.

1993 • 186 citations

Lipoprotein lipase induces catabolism of normal triglyceride-rich lipoproteins via the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor in vitro. A process facilitated by cell-surface proteoglycans

1993 • 185 citations

Internalization of the urokinase-plasminogen activator inhibitor type-1 complex is mediated by the urokinase receptor.

1992 • 184 citations

Insulinlike growth factors. Their regulation of glucose and amino acid transport in placental trophoblasts isolated from first-trimester chorionic villi.

1994 • 170 citations

Resistance of Malignant Trophoblast Cells to both the Anti-proliferative and Anti-invasive Effects of Transforming Growth Factor-β

1994 • 164 citations

The Urokinase-type Plasminogen Activator Receptor Mediates Tyrosine Phosphorylation of Focal Adhesion Proteins and Activation of Mitogen-activated Protein Kinase in Cultured Endothelial Cells

1998 • 162 citations

The Very Low Density Lipoprotein Receptor Mediates the Cellular Catabolism of Lipoprotein Lipase and Urokinase-Plasminogen Activator Inhibitor Type I Complexes

1995 • 153 citations

Receptor‐mediated endocytosis of plasminogen activators and activator/inhibitor complexes

1994 • 148 citations

Identification of the low density lipoprotein receptor-related protein (LRP) as an endocytic receptor for thrombospondin-1.

1995 • 140 citations

Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and scavenger receptor in human atherosclerotic lesions.

1994 • 140 citations

Regions involved in binding of urokinase-type-1 inhibitor complex and pro-urokinase to the endocytic alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Evidence that the urokinase receptor protects pro-urokinase against binding to the endocytic receptor.

1994 • 135 citations

Localization and regulation of the human very low density lipoprotein/apolipoprotein-E receptor: trophoblast expression predicts a role for the receptor in placental lipid transport.

1995 • 130 citations

Cellular Localisation in Placenta of Placental Type Plasminogen Activator Inhibitor

1986 • 126 citations

Plasminogen Activator Inhibitor-1 Contains a Cryptic High Affinity Binding Site for the Low Density Lipoprotein Receptor-related Protein

1998 • 124 citations

Very Low Density Lipoprotein Receptor Binds and Mediates Endocytosis of Urokinase-type Plasminogen Activator-Type-1 Plasminogen Activator Inhibitor Complex

1995 • 112 citations

Alpha 2-macroglobulin-proteinase complexes, plasminogen activator inhibitor type-1-plasminogen activator complexes, and receptor-associated protein bind to a region of the alpha 2-macroglobulin receptor containing a cluster of eight complement-type repeats

1993 • 112 citations

Lysosomal degradation of receptor-bound urokinase-type plasminogen activator is enhanced by its inhibitors in human trophoblastic choriocarcinoma cells.

1990 • 111 citations

Human urokinase-type plasminogen activator primes neutrophils for superoxide anion release. Possible roles of complement receptor type 3 and calcium.

1995 • 104 citations

Enhancement of the Enzymatic Activity of Single-chain Urokinase Plasminogen Activator by Soluble Urokinase Receptor

1995 • 101 citations

Contrasting Effects of Plasminogen Activators, Urokinase Receptor, and LDL Receptor–Related Protein on Smooth Muscle Cell Migration and Invasion

1996 • 100 citations

Embryonic Fibroblasts That Are Genetically Deficient in Low Density Lipoprotein Receptor-related Protein Demonstrate Increased Activity of the Urokinase Receptor System and Accelerated Migration on Vitronectin

1997 • 93 citations

Characterization of urokinase receptor expression by human placental trophoblasts

1992 • 86 citations

Plasminogen‐activator inhibitor type 2 (PAI‐2) is a spontaneously polymerising SERPIN

1993 • 79 citations

Expression of very low density lipoprotein receptor in the vascular wall. Analysis of human tissues by in situ hybridization and immunohistochemistry.

1996 • 74 citations

Expression of urokinase receptors by human trophoblast. A histochemical and ultrastructural analysis.

1994 • 64 citations

Urokinase receptors in human monocytes

1990 • 63 citations

Study of thromboxane and prostacyclin metabolism in an invitro model of first-trimester human trophoblast

1992 • 57 citations

Regulated expression of the trophoblast alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Differentiation and cAMP modulate protein and mRNA levels.

1992 • 56 citations

Interaction of single-chain urokinase with its receptor induces the appearance and disappearance of binding epitopes within the resultant complex for other cell surface proteins

1996 • 53 citations

Induction of LDL receptor-related protein during the differentiation of monocyte-macrophages. Possible involvement in the atherosclerotic process.

1994 • 53 citations

Induction in human osteoblastic cells (SaOS2) of the early response genesfos, jun, andmyc by the amino terminal fragment (ATF) of urokinase

1997 • 51 citations

Human fibroblasts downregulate plasminogen activator inhibitor type-1 in cultured human macrovascular and microvascular endothelial cells

1996 • 39 citations

Expression of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein and the 39-kd receptor-associated protein in human trophoblasts.

1994 • 38 citations

Functions of the LDL Receptor Gene Family

1994 • 34 citations

Processing of complex between urokinase and its type-2 inhibitor on the cell surface

1993 • 22 citations

Thermotaxis of human trophoblastic cells

1996 • 20 citations

Differential regulation of urokinase-type-1 inhibitor complex endocytosis by phorbol esters in different cell lines is associated with differential regulation of α2-macroglobulin receptor and urokinase receptor expression

1995 • 17 citations