New insights into the role of extracellular matrix during tumor onset and progression

Inflammation and cancer: back to Virchow?

2001 • 7,259 citations

Integrin Signaling

1999 • 3,705 citations

The microenvironment of the tumour–host interface

2001 • 2,307 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

Signal transduction from the extracellular matrix.

1993 • 1,727 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 • 1,604 citations

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Localization of Matrix Metalloproteinase MMP-2 to the Surface of Invasive Cells by Interaction with Integrin αvβ3

1996 • 1,555 citations

Matrix Metalloproteinases: Biologic Activity and Clinical Implications

2000 • 1,533 citations

Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium

2000 • 1,445 citations

Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5

1997 • 1,227 citations

A novel metalloproteinase gene specifically expressed in stromal cells of breast carcinomas

1990 • 1,140 citations

The vascular endothelial growth factor (VEGF) isoforms: differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF.

1993 • 1,114 citations

Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

1999 • 937 citations

Molecular architecture of basement membranes

1990 • 937 citations

The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis

1999 • 916 citations

Mechanochemical switching between growth and differentiation during fibroblast growth factor-stimulated angiogenesis in vitro: role of extracellular matrix.

1989 • 877 citations

Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines

1999 • 850 citations

Differentiation repertoire of fibroblastic cells: expression of cytoskeletal proteins as marker of phenotypic modulations.

1990 • 838 citations

Cellular changes involved in conversion of normal to malignant breast: importance of the stromal reaction

1996 • 772 citations

Genetic instability and darwinian selection in tumours

1999 • 748 citations

Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration

2001 • 732 citations

Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo

1999 • 726 citations

The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily.

1995 • 719 citations

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1

2001 • 685 citations

The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis

2001 • 677 citations

Role of Cell Surface Metalloprotease Mt1-Mmp in Epithelial Cell Migration over Laminin-5

2000 • 650 citations

Disruption of Angiogenesis by PEX, a Noncatalytic Metalloproteinase Fragment with Integrin Binding Activity

1998 • 618 citations

Multi‐faceted regulation of cell differentiation by extracellular matrix

1993 • 610 citations

The Degradation of Human Endothelial Cell-derived Perlecan and Release of Bound Basic Fibroblast Growth Factor by Stromelysin, Collagenase, Plasmin, and Heparanases

1996 • 601 citations

Heterotypic Signaling between Epithelial Tumor Cells and Fibroblasts in Carcinoma Formation

2001 • 554 citations

Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells.

2000 • 537 citations

Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information

1992 • 532 citations

Extracellular matrix remodelling and cellular differentiation

1999 • 512 citations

Hyaluronan in Peritumoral Stroma and Malignant Cells Associates with Breast Cancer Spreading and Predicts Survival

2000 • 493 citations

Kaposi's Sarcoma-Associated Herpesvirus Infection of Bone Marrow Dendritic Cells from Multiple Myeloma Patients

1997 • 491 citations

Integrin alpha v beta 3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen.

1994 • 447 citations

Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas.

1991 • 440 citations

Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-β1 release

1997 • 428 citations

Know thy neighbor: stromal cells can contribute oncogenic signals

2001 • 422 citations

TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages.

1996 • 409 citations

Osteopontin Identified as Lead Marker of Colon Cancer Progression, Using Pooled Sample Expression Profiling

2002 • 404 citations

Vascular stroma formation in carcinoma in situ, invasive carcinoma, and metastatic carcinoma of the breast.

1999 • 361 citations

Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.

1996 • 353 citations

Fibronectin and Its Integrin Receptors in Cancer

1999 • 338 citations

Matrix metalloproteinases and tumor invasion: from correlation and causality to the clinic

1996 • 337 citations

Stromal cells can contribute oncogenic signals

2001 • 326 citations

The generation of endostatin is mediated by elastase.

1999 • 295 citations

Induction of Hepatocyte Growth Factor in Fibroblasts by Tumor-derived Factors Affects Invasive Growth of Tumor Cells : In Vitro Analysis of Tumor-Stromal Interactions

1998 • 291 citations

Laminin receptors: achieving specificity through cooperation

1995 • 225 citations

Cathepsin B: association with plasma membrane in metastatic tumors.

1986 • 222 citations

Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure.

1990 • 213 citations

Interactions between human tumor cells and fibroblasts stimulate hyaluronate synthesis.

1984 • 203 citations

Mechanisms Controlling the Transcription of Matrix Metalloproteinase Genes in Normal and Neoplastic Cells

1996 • 194 citations

Receptor for urokinase is present in tumor-associated macrophages in ductal breast carcinoma.

1993 • 192 citations

The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study.

1995 • 183 citations

Cathepsin B Activity Regulation

2001 • 182 citations

The overexpression of RHAMM, a hyaluronan-binding protein that regulates ras signaling, correlates with overexpression of mitogen-activated protein kinase and is a significant parameter in breast cancer progression.

1998 • 175 citations

Tumors are unique organs defined by abnormal signaling and context

2001 • 174 citations

Cathepsin B and human tumor progression.

1998 • 173 citations

EMMPRIN (CD147), an inducer of matrix metalloproteinase synthesis, also binds interstitial collagenase to the tumor cell surface.

2000 • 172 citations

Matrilysin mediates extracellular cleavage of E-cadherin from prostate cancer cells: a key mechanism in hepatocyte growth factor/scatter factor-induced cell-cell dissociation and in vitro invasion.

2001 • 168 citations

Vitronectin, a glioma-derived extracellular matrix protein, protects tumor cells from apoptotic death.

1999 • 167 citations

Assembly of extracellular matrix

1992 • 159 citations

The 67 kDa laminin receptor as a prognostic factor in human cancer

1998 • 149 citations

Degradation of basement membrane laminin by human neutrophil elastase and cathepsin G.

1990 • 143 citations

Prognostic Significance of the 67-Kilodalton Laminin Receptor Expression in Human Breast Carcinomas

1993 • 142 citations

High Affinity Binding of Latent Matrix Metalloproteinase-9 to the α2(IV) Chain of Collagen IV

1998 • 138 citations

Reduction in drug-induced DNA double-strand breaks associated with β1 integrin–mediated adhesion correlates with drug resistance in U937 cells

2001 • 135 citations

Tumor Collagenase Stimulatory Factor (TCSF) Expression and Localization in Human Lung and Breast Cancers

1997 • 131 citations

Identification of a 110-kDa nonintegrin cell surface laminin-binding protein which recognizes an a chain neurite-promoting peptide

1991 • 127 citations

Oligomerization-Dependent Regulation of Motility and Morphogenesis by the Collagen Xviii Nc1/Endostatin Domain

2001 • 114 citations

Messenger RNA for urokinase plasminogen activator is expressed in myofibroblasts adjacent to cancer cells in human breast cancer.

1996 • 110 citations

The extracellular matrix as a cell cycle control element in atherosclerosis and restenosis.

1997 • 107 citations

Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: comparison with cathepsin D, cathepsin L, and other clinical indicators.

2000 • 98 citations

Estrogen induction and overexpression of fibulin-1C mRNA in ovarian cancer cells

2002 • 95 citations

Enhanced collagenase production by fibroblasts derived from human basal cell carcinomas.

1979 • 95 citations

The Interaction of Fibulin-1 with Fibrinogen

1995 • 90 citations

Identification of a novel function for 67-kDa laminin receptor: increase in laminin degradation rate and release of motility fragments.

2002 • 80 citations

Reversal of intrinsic and acquired forms of drug resistance by hyaluronidase treatment of solid tumors

1998 • 80 citations

Estrogens increase the expression of fibulin-1, an extracellular matrix protein secreted by human ovarian cancer cells.

1996 • 73 citations

The extracellular matrix as a cell cycle control element in atherosclerosis and restenosis.

1996 • 70 citations

Beta 1 integrin expression on human small cell lung cancer cells.

1991 • 67 citations

Analysis of integrin receptors for laminin and type IV collagen on metastatic B16 melanoma cells.

1990 • 67 citations

Exposure of Cryptic Domains in the α1-chain of Laminin-1 by Elastase Stimulates Macrophages Urokinase and Matrix Metalloproteinase-9 Expression

2002 • 58 citations

Identification of Breast Cancer-Restricted Antigens by Antibody Screening of SKBR3 cDNA Library Using a Preselected Patient's Serum

2002 • 56 citations

Altered biochemical properties of actin in normal skin fibroblasts from individuals predisposed to dominantly inherited cancers.

1986 • 51 citations

Peptide G, Containing the Binding Site of the 67-kDa Laminin Receptor, Increases and Stabilizes Laminin Binding to Cancer Cells

1996 • 51 citations

Functional role of α4β1 and α5β1 integrin fibronectin receptors expressed on adriamycin-resistant MCF-7 human mammary carcinoma cells

1997 • 45 citations

Inhibition of tumour cell invasion by protease inhibitors: correlation with the protease profile

1998 • 45 citations

Signalling by adhesion receptors

2000 • 37 citations

Prognostic significance of laminin production in relation with its receptor expression in human breast carcinomas

1995 • 32 citations

The ability in adhesion and invasion of drug-resistant human glioma cells.

2000 • 31 citations

Genetic Predisposition to Cancer in Man: In Vitro Studies

1982 • 31 citations

Selective modulation of collagenase 1 gene expression by the chemotherapeutic agent doxorubicin.

1999 • 29 citations

Altered expression of integrins in adriamycin-resistant human breast cancer cells.

1998 • 27 citations

Shedding of the 67-kD laminin receptor by human cancer cells

1996 • 26 citations

The crossroads between cell–cell adhesion and motility

2000 • 24 citations

Cathepsin D expression by cancer and stromal cells in breast cancer: an immunohistochemical study of 1348 cases

1999 • 24 citations

Changes in Quantitative Profile of Extracellular Matrix Components in the Kidneys of Rats with Adriamycin-induced Nephropathy.

2001 • 22 citations

Identification of a Clonal Form of HIV in Early Kaposi??s Sarcoma

1995 • 22 citations

Cell surface and substrate distribution of the 67-kDa laminin-binding protein determined by using a ligand photoaffinity probe

1999 • 21 citations

Regional variations of urokinase‐type plasminogen activator in human colorectal cancer: A quantitative study by image analysis

1995 • 18 citations

Inhibition of mammary tumorigenesis by a reduction of fat intake after carcinogen treatment in young versus adult rats

1980 • 16 citations

Laminin activates the p185HER2 oncoprotein and mediates growth inhibition of breast carcinoma cells

1996 • 16 citations

Fibronectin turnover in human mesangial cell cultures as affected by Adriamycin

1993 • 5 citations