Inhibition of Metastasis of Intraocular Melanomas by Adenovirus-Mediated Gene Transfer of Plasminogen Activator Inhibitor Type 1 (PAI-1) in an Athymic Mouse Model

Plasminogen Activators, Tissue Degradation, and Cancer

1985 • 2,584 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Plasminogen activator inhibitors

1987 • 957 citations

Plasminogen activator inhibitors

1987 • 764 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Epidemiologic aspects of uveal melanoma

1988 • 535 citations

Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice.

1993 • 531 citations

Inhibition of receptor-bound urokinase by plasminogen-activator inhibitors.

1990 • 272 citations

Immune Privilege and Immune Regulation in the Eye

1990 • 265 citations

Adenovirus vector-mediated in vivo gene transfer into adult murine retina.

1994 • 239 citations

In vivo transfer of a reporter gene to the retina mediated by an adenoviral vector.

1994 • 183 citations

Infection of eucaryotic cells by helper-independent recombinant adenoviruses: early region 1 is not obligatory for integration of viral DNA

1984 • 170 citations

Expression of plasminogen activator inhibitor type 1 by human prostate carcinoma cells inhibits primary tumor growth, tumor-associated angiogenesis, and metastasis to lung and liver in an athymic mouse model.

1995 • 160 citations

The role of urokinase-type plasminogen activator in aggressive tumor cell behavior

1990 • 158 citations

Deviant immune responses to allogeneic tumors injected intracamerally and subcutaneously in mice.

1981 • 156 citations

Gene Therapy's Growing Pains

1995 • 133 citations

Characterization of uveal melanoma cell lines that grow as xenografts in rabbit eyes.

1989 • 133 citations

Overexpression of plasminogen activator inhibitor 2 in human melanoma cells inhibits spontaneous metastasis in scid/scid mice.

1995 • 131 citations

Treatment of metastatic uveal melanoma: Review and recommendations

1992 • 124 citations

Radial caseinolysis in agarose: A simple method for detection of plasminogen activator in the presence of inhibitory substances and serum

1981 • 122 citations

In vivo gene transfer into murine corneal endothelial and trabecular meshwork cells.

1995 • 112 citations

Gene therapy's growing pains

1995 • 103 citations

Type‐1 plasminogen activator inhibitor in human breast carcinomas

1992 • 100 citations

Adenovirus-mediated heme oxygenase-1 gene transfer into rabbit ocular tissues.

1995 • 96 citations

Lack of plasminogen activator inhibitor-1 effect in a transgenic mouse model of metastatic melanoma

1996 • 94 citations

Biologic distinctions between cure and time to death in 2892 patients with intraocular melanoma

1993 • 93 citations

Functional inhibition of endogenously produced urokinase decreases cell proliferation in a human melanoma cell line.

1989 • 91 citations

Adenovirus-mediated gene transfer

1993 • 90 citations

Characterization of a plasminogen activator produced by Acanthamoeba castellanii

1995 • 69 citations

Relationship between natural killer cell susceptibility and metastasis of human uveal melanoma cells in a murine model.

1995 • 69 citations

Adenovirus‐mediated gene transfer to murine retinal cells in vitro and in vivo

1994 • 64 citations

Deacylated lipopolysaccharide inhibits plasminogen activator inhibitor-1, prostacyclin, and prostaglandin E2 induction by lipopolysaccharide but not by tumor necrosis factor-alpha.

1990 • 55 citations

Metastatic Uveal Melanoma

1985 • 55 citations

Plasminogen activation by t-PA on the surface of human melanoma cells in the presence of alpha 2-macroglobulin secretion.

1990 • 44 citations

Components of the plasminogen activation system in uveal melanoma—a clinico‐pathological study

1995 • 38 citations

Characterization of intraocular tumors arising in transgenic mice.

1994 • 36 citations

Tissue-type plasminogen activator-induced invasion and metastasis of murine melanomas

1995 • 33 citations

Measurement of different forms of plasminogen activator inhibitor 1(PAI-1) using various monoclonal antibody-based enzyme-linked immunosorbent assays

1990 • 22 citations

Efficacy of tumor-infiltrating lymphocytes in the treatment of hepatic metastases arising from transgenic intraocular tumors in mice.

1995 • 18 citations