Novel Inhibitors of Plasminogen Activator Inhibitor-1: Development of New Templates From Diketopiperazines

Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants.

1985 • 555 citations

Structural basis of latency in plasminogen activator inhibitor-1

1992 • 552 citations

Plasminogen Activator Inhibitor 1 (PAI-1) in Plasma: Its Role in Thrombotic Disease

1995 • 198 citations

Inhibition of plasminogen activator inhibitor-1 activity results in promotion of endogenous thrombolysis and inhibition of thrombus extension in models of experimental thrombosis.

1992 • 198 citations

The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion

1999 • 154 citations

Identification of a conformationally distinct form of plasminogen activator inhibitor-1, acting as a noninhibitory substrate for tissue-type plasminogen activator.

1992 • 142 citations

Thrombolysis and Reocclusion in Experimental Jugular Vein and Coronary Artery Thrombosis

1995 • 108 citations

Peptide-mediated inactivation of recombinant and platelet plasminogen activator inhibitor-1 in vitro.

1995 • 100 citations

Interconversions between active, inert and substrate forms of denatured/refolded type-1 plasminogen activator inhibitor

1993 • 92 citations

Novel low-molecular-weight inhibitor of PAI-1 (XR5118) promotes endogenous fibrinolysis and reduces postthrombolysis thrombus growth in rabbits.

1997 • 91 citations

A substrate‐like form of plasminogen‐activator‐inhibitor type 1

1992 • 90 citations

Evaluation of a Low Molecular Weight Modulator of Human Plasminogen Activator Inhibitor-1 Activity

1996 • 78 citations

Identification of the Binding Site for a Low-Molecular-Weight Inhibitor of Plasminogen Activator Inhibitor Type 1 by Site-Directed Mutagenesis

1998 • 63 citations

Inhibition of Plasminogen Activator Inhibitor-1 Activity by Two Diketopiperazines, XR330 and XR334 Produced by Streptomyces sp.

1996 • 61 citations

Synthesis and in vitro evaluation of a series of diketopiperazine inhibitors of plasminogen activator inhibitor-1

2001 • 58 citations

Extending the capabilities of targeted molecular dynamics: Simulation of a large conformational transition in plasminogen activator inhibitor 1

2001 • 41 citations

Anti-thrombotic Effect of a PAI-1 Inhibitor in Rats Given Endotoxin

1996 • 35 citations

Inhibition of type-1 plasminogen activator inhibitor production by antisense oligonucleotides in human vascular endothelial and smooth muscle cells.

1994 • 28 citations

XR5118, a novel modulator of plasminogen activator inhibitor-1 (PAI-1), increases endogenous tPA activity in the rat

1997 • 27 citations

Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. II. Structural determination and total synthesis.

1988 • 26 citations

Über die Synthese von 1,4‐Benzoxazepinen und ihre Umlagerung in Isochinoline

1968 • 19 citations

4‐Hydroxy‐1(2H)‐isoquinolone‐3‐carboxamides synthesis and properties

1985 • 16 citations

Inhibition by Modified Oligodeoxynucleotides of the Expression of Type‐1 Plasminogen Activator Inhibitor in Human Endothelial Cells

1995 • 15 citations

Ueber 4‐Oxyisocarbostyril. II

1902 • 13 citations

An antibody ragment against PAI-1 inhibits PAI-1 activity and stimulates fibrinolysis in vitro and in vivo

1994 • 11 citations

Stereoselective Synthesis of the Geometric and Optical Isomers of Unsaturated 3-Mono- and 3,6-Disubstituted 2,5-Piperazinediones

1983 • 10 citations

Cyclic imides III. A study of the hydroxy‐ and methoxyphthalimidoacetic acids and the methyl methoxyphthalimidoacetates

1966 • 9 citations

Molecular and electronic structure of the dehydroalanine derivatives: The cyclic dipeptide of dehydrophenylalanine

1985 • 7 citations

The status of plasminogen activator inhibitor-1 as a therapeutic target

1997 • 6 citations