Plasminogen activator inhibitor‐1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Integrins αvβ3 and αvβ5 promote adenovirus internalization but not virus attachment

1993 • 2,182 citations

The urokinase-type plasminogen activator system in cancer metastasis: A review

1997 • 1,561 citations

Implications of the three-dimensional structure of .alpha.1-antitrypsin for structure and function of serpins

1989 • 898 citations

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization

1998 • 683 citations

The serpin PAI-1 inhibits cell migration by blocking integrin αvβ3 binding to vitronectin

1996 • 680 citations

Identification of the urokinase receptor as an adhesion receptor for vitronectin.

1994 • 593 citations

Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants.

1985 • 555 citations

Novel purification of vitronectin from human plasma by heparin affinity chromatography.

1988 • 525 citations

Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin).

1988 • 484 citations

Plasminogen activators, integrins, and the coordinated regulation of cell adhesion and migration

1997 • 472 citations

Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

1996 • 460 citations

Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein

1977 • 427 citations

Glioblastoma expression of vitronectin and the alpha v beta 3 integrin. Adhesion mechanism for transformed glial cells.

1991 • 420 citations

A Role for Caveolin and the Urokinase Receptor in Integrin-mediated Adhesion and Signaling

1999 • 402 citations

Receptor-mediated internalization and degradation of urokinase is caused by its specific inhibitor PAI-1.

1990 • 374 citations

A Role for Tissue Factor in Cell Adhesion and Migration Mediated by Interaction with Actin-binding Protein 280

1998 • 313 citations

Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin.

1997 • 288 citations

The Adipocyte and Hemostatic Balance in Obesity

1998 • 270 citations

uPA, uPAR, PAI-I: Key intersection of proteolytic, adhesive and chemotacfic highways?

1997 • 246 citations

Role of Vitronectin and Its Receptors in Haemostasis and Vascular Remodeling

1998 • 237 citations

Plasminogen Activator Inhibitor-1 Represses Integrin- and Vitronectin-Mediated Cell Migration Independently of Its Function as an Inhibitor of Plasminogen Activation

1997 • 234 citations

Urokinase-type plasminogen activator receptors associate with beta1 and beta3 integrins of fibrosarcoma cells: dependence on extracellular matrix components.

1997 • 222 citations

Serotonin 5-HT2a and 5-HT2c Receptors Stimulate Amyloid Precursor Protein Ectodomain Secretion

1996 • 221 citations

Reversible cellular adhesion to vitronectin linked to urokinase receptor occupancy.

1994 • 216 citations

Cellular growth and survival are mediated by β1 integrins in normal human breast epithelium but not in breast carcinoma

1995 • 203 citations

Purification of a Protein from Bovine Plasma That Binds to Type 1 Plasminogen Activator Inhibitor and Prevents Its Interaction with Extracellular Matrix

1989 • 197 citations

Vitronectin is not essential for normal mammalian development and fertility.

1995 • 188 citations

Accessibility of receptor-bound urokinase to type-1 plasminogen activator inhibitor.

1989 • 182 citations

Plasminogen activator inhibitor 1 (PAI) is bound to vitronectin in plasma

1988 • 178 citations

Plasminogen Activator Inhibitor-1 and Its Cofactor Vitronectin Stabilize Arterial Thrombi After Vascular Injury in Mice

2001 • 165 citations

Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin.

1991 • 157 citations

Structure of plasminogen activator inhibitor 1 (PAI-1) and its function in fibrinolysis: an update

1995 • 153 citations

The Cell Adhesion Domain in Plasma Vitronectin Is Cryptic

1997 • 131 citations

The somatomedin B domain of vitronectin. Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor.

1994 • 126 citations

Structural requirements for the extracellular interaction of plasminogen activator inhibitor 1 with endothelial cell matrix-associated vitronectin.

1990 • 116 citations

Vitronectin Inhibits the Thrombotic Response to Arterial Injury in Mice

1999 • 114 citations

Overexpressed Csk Tyrosine Kinase Is Localized in Focal Adhesions, Causes Reorganization of α_vβ₅ Integrin, and Interferes with Hela Cell Spreading

1995 • 112 citations

Posttranscriptional regulation of cellular gene expression by the c-myc oncogene.

1989 • 108 citations

Structural and Functional Analysis of the Plasminogen Activator Inhibitor-1 Binding Motif in the Somatomedin B Domain of Vitronectin

1996 • 103 citations

Human urokinase receptor concentration in malignant and benign breast tumors by in vitro quantitative autoradiography: comparison with urokinase levels.

1993 • 102 citations

Binding of Type 1 Plasminogen Activator Inhibitor to the Extracellular Matrix of Cultured Bovine Endothelial Cells

1989 • 94 citations

Kinetics of inactivation of alpha-thrombin by plasminogen activator inhibitor-1. Comparison of the effects of native and urea-treated forms of vitronectin

1993 • 91 citations

A spectrophotometric solid-phase fibrin-tissue plasminogen activator activity assay (SOFIA-tPA) for high-fibrin-affinity tissue plasminogen activator

1986 • 88 citations

Serum-derived vitronectin influences the pericellular distribution of type 1 plasminogen activator inhibitor.

1990 • 86 citations

Vitronectin deficiency is associated with increased wound fibrinolysis and decreased microvascular angiogenesis in mice

2000 • 75 citations

Immunoradiometric assay to measure the binding of a specific inhibitor to tissue-type plasminogen activator.

1985 • 74 citations

The PAI-1/Vitronectin Interaction: Two Cats in a Bag?

1995 • 70 citations

Vitronectin regulates the synthesis and localization of urokinase-type plasminogen activator in HT-1080 cells.

1992 • 65 citations

Vitronectin binding to urokinase receptor in human breast cancer.

1997 • 55 citations

Ligand-receptor interactions of the low density lipoprotein receptor-related protein, a multi-ligand endocytic receptor

1998 • 46 citations

Synthetic peptides derived from the sequence around the plasmin cleavage site in vitronectin

1993 • 44 citations

Integrin expression on colorectal tumor cells growing as monolayers, as multicellular tumor spheroids, or in nude mice

1995 • 44 citations

The cluster of basic amino acids in vitronectin contributes to its binding of plasminogen activator inhibitor-1: evidence from thrombin-, elastase- and plasmin-cleaved vitronectins and anti-peptide antibodies

1997 • 44 citations

Targeted gene manipulation and transfer of the plasminogen and coagulation systems in mice

1996 • 40 citations

Kinetic analysis of integrin‐dependent cell adhesion on vitronectin

1998 • 40 citations

Vitronectin in Colorectal Adenocarcinoma—Synthesis by Stromal Cells in Culture

1994 • 37 citations

Identification of a PAI-1 binding site in vitronectin

1994 • 35 citations

Progress in Hemostasis and Thrombosis

1978 • 34 citations

Two human melanoma cell‐line variants with enhanced in vivo tumor growth and metastatic capacity do not express the β₃ integrin subunit

1994 • 29 citations

Loss of α₁β₁ and reduced expression of other β₁ integrins and cam in lung adenocarcinoma compared with pneumocytes

1994 • 27 citations

Structural and Functional Characterization of Vitronectin‐Derived RGD‐Containing Peptides from Human Hemofiltrate

1996 • 22 citations

Plasminogen activators and inhibitor type 1 in neoplastic colonic tissue from patients with familial adenomatous polyposis

1995 • 21 citations

Plasmin-catalyzed proteolysis in colorectal neoplasia.

1995 • 19 citations

Cell matrix adhesions and localization of the vitronectin receptor in MCF-7 human mammary carcinoma cells

1998 • 17 citations

Characterization of a complex between active plasminogen activator inhibitor-1 and N-terminal fragments of vitronectin from human placenta

2000 • 5 citations

A Protein Reacted with Anti-vitronectin Antibody Accumulates in Tumors Derived from B16F10 Melanoma Cells.

1998 • 4 citations