The p41 isoform of invariant chain is a chaperone for cathepsin L

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

1992 • 3,751 citations

Cathepsin L: Critical Role in Ii Degradation and CD4 T Cell Selection in the Thymus

1998 • 654 citations

Accelerated transport and maturation of lysosomal α–galactosidase A in Fabry lymphoblasts by an enzyme inhibitor

1999 • 603 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Essential Role for Cathepsin S in MHC Class II–Associated Invariant Chain Processing and Peptide Loading

1996 • 523 citations

Cathepsin S Required for Normal MHC Class II Peptide Loading and Germinal Center Development

1999 • 519 citations

Vinyl Sulfones as Mechanism-Based Cysteine Protease Inhibitors

1995 • 496 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-Induced Arthritis in Cathepsin S Null Mice

1999 • 408 citations

Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.

1996 • 379 citations

Developmental Regulation of Invariant Chain Proteolysis Controls MHC Class II Trafficking in Mouse Dendritic Cells

1998 • 378 citations

THE LYSOSOMAL CYSTEINE PROTEASES

1999 • 353 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages.

1995 • 309 citations

How MHC Class II Molecules Acquire Peptide Cargo: Biosynthesis and Trafficking through the Endocytic Pathway

1995 • 280 citations

Proteases involved in MHC dass II antigen presentation

1999 • 235 citations

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

1991 • 234 citations

Cathepsin S Controls the Trafficking and Maturation of Mhc Class II Molecules in Dendritic Cells

1999 • 227 citations

Regulation of Elastinolytic Cysteine Proteinase Activity in Normal and Cathepsin K–Deficient Human Macrophages

2000 • 216 citations

Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S

1999 • 207 citations

Lysosomal Enzyme Trafficking between Phagosomes, Endosomes, and Lysosomes in J774 Macrophages

1998 • 201 citations

Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments

1995 • 198 citations

Degradation of Mouse Invariant Chain: Roles of Cathepsins S and D and the Influence of Major Histocompatibility Complex Polymorphism

1997 • 188 citations

Proteolysis in MHC Class II Antigen Presentation

2000 • 181 citations

Major histocompatibility complex class II-associated p41 invariant chain fragment is a strong inhibitor of lysosomal cathepsin L.

1996 • 174 citations

Characterization and inhibition of a cholecystokinin-inactivating serine peptidase

1996 • 168 citations

Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain.

1986 • 162 citations

Abundant empty class II MHC molecules on the surface of immature dendritic cells

1999 • 152 citations

Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin.

1987 • 147 citations

Biosynthesis of lysosomal endopeptidases

1989 • 128 citations

Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41

1992 • 124 citations

Gamma‐interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages

1995 • 93 citations

pH-induced Conformational Transitions of the Propeptide of Human Cathepsin L

1998 • 93 citations

Procathepsins L and D are membrane-bound in acidic microsomal vesicles

1991 • 87 citations

Four Ia invariant chain forms derive from a single gene by alternate splicing and alternate initiation of transcription/translation.

1987 • 85 citations

Involvement of the vacuolar H(+)-ATPases in the secretory pathway of HepG2 cells.

1993 • 82 citations

The pH-dependent membrane association of procathepsin L is mediated by a 9-residue sequence within the propeptide.

1994 • 74 citations

Differential expression of the invariant chain in mouse tumor cells: relationship to B lymphoid development.

1984 • 66 citations

Purification of the complex of cathepsin L and the MHC class II‐associated invariant chain fragment from human kidney

1993 • 63 citations

The proteolytic environment involved in MHC class II-restricted antigen presentation can be modulated by the p41 form of invariant chain.

1996 • 44 citations

Multiple Processing of Procathepsin L to Cathepsin Lin Vivo

1998 • 40 citations

Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chain

1995 • 36 citations

Invariant Chain Controls H2-M Proteolysis in Mouse Splenocytes and Dendritic Cells

2000 • 36 citations

[22] Subcellular localization of Rab17 by cryo-immunogold electron microscopy in epithelial cells grown on polycarbonate filters

2001 • 28 citations

Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties

1999 • 20 citations

In vivo functions mediated by the p41 isoform of the MHC class II-associated invariant chain.

1997 • 17 citations