Regulation of Elastinolytic Cysteine Proteinase Activity in Normal and Cathepsin K–Deficient Human Macrophages

Expression monitoring by hybridization to high-density oligonucleotide arrays

1996 • 2,796 citations

Matrix Metalloproteinases and Other Matrix Proteinases in Relation to Cariology: The Era of ‘Dentin Degradomics'

2015 • 2,211 citations

Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

1997 • 1,463 citations

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells.

1991 • 1,269 citations

Pycnodysostosis, a Lysosomal Disease Caused by Cathepsin K Deficiency

1996 • 1,003 citations

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

1998 • 900 citations

Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts*1

1988 • 887 citations

EMERGING ROLES FOR CYSTEINE PROTEASES IN HUMAN BIOLOGY

1997 • 767 citations

Cell-mediated extracellular acidification and bone resorption: evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border.

1985 • 738 citations

Matrix Metalloproteinases Regulate Neovascularization by Acting as Pericellular Fibrinolysins

1998 • 716 citations

Cathepsin K, but Not Cathepsins B, L, or S, Is Abundantly Expressed in Human Osteoclasts

1996 • 706 citations

Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation

1997 • 664 citations

Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells.

1998 • 646 citations

The Collagenolytic Activity of Cathepsin K Is Unique among Mammalian Proteinases

1998 • 631 citations

STRUCTURE, FUNCTION AND REGULATION OF THE VACUOLAR (H⁺)-ATPase

1997 • 588 citations

Lysosomes Behave as Ca2+-regulated Exocytic Vesicles in Fibroblasts and Epithelial Cells

1997 • 520 citations

Proteolytic Activity of Human Osteoclast Cathepsin K

1996 • 494 citations

Secreted cathepsin L generates endostatin from collagen XVIII

2000 • 459 citations

Cystatin C deficiency in human atherosclerosis and aortic aneurysms

1999 • 444 citations

Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells.

1995 • 436 citations

Human Cathepsin O2, a Matrix Protein-degrading Cysteine Protease Expressed in Osteoclasts

1996 • 427 citations

Pericellular pH affects distribution and secretion of cathepsin B in malignant cells.

1994 • 360 citations

Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix

1998 • 343 citations

Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts.

1994 • 340 citations

Strong Induction of Members of the Chitinase Family of Proteins in Atherosclerosis

1999 • 316 citations

Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages.

1995 • 309 citations

Cross-Class Inhibition of the Cysteine Proteinases Cathepsins K, L, and S by the Serpin Squamous Cell Carcinoma Antigen 1: A Kinetic Analysis

1998 • 279 citations

Secretion of lysosomal hydrolases by stimulated and nonstimulated macrophages.

1978 • 241 citations

The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma.

1997 • 218 citations

Lysosomal Enzyme Trafficking between Phagosomes, Endosomes, and Lysosomes in J774 Macrophages

1998 • 201 citations

Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2

1995 • 167 citations

Differential Sorting of Lysosomal Enzymes Out of the Regulated Secretory Pathway in Pancreatic β-Cells

1997 • 166 citations

Correlation of the topographical arrangement and the functional pattern of tissue-infiltrating macrophages in giant cell arteritis.

1996 • 165 citations

Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH

1984 • 153 citations

Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction.

1998 • 149 citations

Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur

1998 • 131 citations

In Vitro Fusion of Phagosomes with Different Endocytic Organelles from J774 Macrophages

1998 • 127 citations

Localization of Rat Cathepsin K in Osteoclasts and Resorption Pits: Inhibition of Bone Resorption and Cathepsin K-Activity by Peptidyl Vinyl Sulfones

1999 • 126 citations

Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes.

1996 • 123 citations

Secretory lysosomes — a special mechanism of regulated secretion in haemopoietic cells

1996 • 107 citations

Cathepsin B and glioma invasion

1999 • 102 citations

A fluorescence quenching technique using trypan blue to differentiate between attached and ingested glutaraldehyde-fixed red blood cells in phagocytosing murine macrophages

1983 • 98 citations

Effect of proteinase inhibitors on intracellular processing of cathepsin B, H and L in rat macrophages

1988 • 94 citations

Expression of Cathepsin K in Lung Epithelial Cells

1999 • 85 citations

Sequestration of acetylated LDL and cholesterol crystals by human monocyte-derived macrophages.

1995 • 83 citations

Relative roles of Na⁺/H⁺ exchange and vacuolar‐type H⁺ ATPases in regulating cytoplasmic pH and function in murine peritoneal macrophages

1993 • 64 citations

Secretion and localization of cathepsin D in synovial tissues removed from rheumatoid and traumatized joints. An immunohistochemical study

1976 • 61 citations

Structure and Chromosomal Assignment of the Human Cathepsin K Gene

1997 • 61 citations

Inhibition of the acidification of endosomes and lysosomes by the antibiotic concanamycin B in macrophage J774

1992 • 58 citations

Biosynthesis and transport of lysosomal enzymes in human monocytes and macrophages. Effects of ammonium chloride, zymosan and tunicamycin

1983 • 58 citations

Mutations of CTSK Result in Pycnodysostosis via a Reduction in Cathepsin K Protein

1999 • 55 citations

Expression of cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues

1999 • 55 citations

Genomic Organization and Chromosome Localization of the Human Cathepsin K Gene (CTSK)

1997 • 51 citations

Macrophage cathepsin L, a factor in the erosion of subchondral bone in rheumatoid arthritis

1997 • 48 citations

Assessment of Na+-H+ exchange activity in phagosomal membranes of human neutrophils

1988 • 34 citations

A Novel Transcription Factor Regulates Expression of the Vacuolar H+-ATPase B2 Subunit through AP-2 Sites during Monocytic Differentiation

1997 • 27 citations

Protein synthesis-dependent and protein synthesis-independent secretion of lysosomal hydrolases from rabbit and human macrophages.

1982 • 23 citations

Effect of Carbohydrate Position on Lysosomal Transport of Procathepsin L

1998 • 8 citations

Involvement of V-ATPases in the Digestion of Soft Connective Tissue Collagen

1998 • 7 citations