Abundant empty class II MHC molecules on the surface of immature dendritic cells

Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.

1994 • 5,204 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide

1994 • 1,553 citations

Current protocols in immunology

1992 • 1,464 citations

MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation

1994 • 1,448 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens

1979 • 993 citations

The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing

1995 • 959 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

1997 • 860 citations

CAPTURE AND PROCESSING OF EXOGENOUS ANTIGENS FOR PRESENTATION ON MHC MOLECULES

1997 • 779 citations

Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

1992 • 763 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies.

1990 • 561 citations

Expression of MHC class II molecules in different cellular and functional compartments is controlled by differential usage of multiple promoters of the transactivator CIITA

1997 • 510 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Mouse monoclonal antibodies against rat major histocompatibility antigens. Two Ia antigens and expression of Ia and class I antigens in rat thymus

1982 • 364 citations

Mice Lacking the MHC Class II Transactivator (CIITA) Show Tissue-Specific Impairment of MHC Class II Expression

1996 • 356 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Cathepsin S activity regulates antigen presentation and immunity.

1998 • 307 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

Crystal Structure of I-Ak in Complex with a Dominant Epitope of Lysozyme

1998 • 245 citations

Crystal Structures of Two I-Ad–Peptide Complexes Reveal That High Affinity Can Be Achieved without Large Anchor Residues

1998 • 236 citations

Ligand-specific oligomerization of T-cell receptor molecules

1997 • 232 citations

Cell surface HLA-DR-invariant chain complexes are targeted to endosomes by rapid internalization.

1993 • 221 citations

The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail.

1993 • 206 citations

Extracellular antigen processing and presentation by immature dendritic cells

1999 • 190 citations

Processing of lysozyme by macrophages: identification of the determinant recognized by two T-cell hybridomas.

1984 • 175 citations

How MHC class II molecules reach the endocytic pathway.

1995 • 173 citations

Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules

1993 • 157 citations

Empty and peptide-containing conformers of class I major histocompatibility complex molecules expressed in Drosophila melanogaster cells.

1992 • 143 citations

Expression of a class II major histocompatibility complex (MHC) heterodimer in a lipid-linked form with enhanced peptide/soluble MHC complex formation at low pH.

1991 • 143 citations

Related Leucine-based Cytoplasmic Targeting Signals in Invariant Chain and Major Histocompatibility Complex Class II Molecules Control Endocytic Presentation of Distinct Determinants in a Single Protein

1997 • 135 citations

Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein.

1996 • 134 citations

Formation of a Highly Peptide-Receptive State of Class II MHC

1998 • 133 citations

Thermal Stability Comparison of Purified Empty and Peptide-Filled Forms of a Class I MHC Molecule

1992 • 132 citations

Capacity of intact proteins to bind to MHC class II molecules.

1989 • 129 citations

Rapid Extracellular Degradation of Synthetic Class I Peptides by Human Dendritic Cells

1998 • 106 citations

Processing and Presentation of Endocytically Acquired Protein Antigens by MHC Class II and Class I Molecules

1996 • 99 citations

Empty and Peptide-Loaded Class II Major Histocompatibility Complex Proteins Produced by Expression inEscherichia coliand Foldingin Vitro

1999 • 97 citations

Mice lacking the transcription factor CIITA--a second look.

1998 • 95 citations

Structural characterization of a soluble and partially folded class I major histocompatibility heavy chain/β2m heterodimer

1998 • 90 citations

A Conformational Change in the Human Major Histocompatibility Complex Protein HLA-DR1 Induced by Peptide Binding

1999 • 83 citations

Evidence that binding site occupancy is necessary and sufficient for effective major histocompatibility complex (MHC) class II transport through the secretory pathway redefines the primary function of class II-associated invariant chain peptides (CLIP).

1996 • 77 citations

Peptide loading onto recycling HLA-DR molecules occurs in early endosomes

1998 • 75 citations

Mouse B lymphocyte specific endocytosis and recycling of MHC class II molecules.

1990 • 75 citations

Large Protein Fragments as Substrates for Endocytic Antigen Capture by MHC Class II Molecules

1998 • 73 citations

Residual MHC Class II Expression on Mature Dendritic Cells and Activated B Cells in RFX5-Deficient Mice

1998 • 69 citations

Intracellular Pathway for the Generation of Functional MHC Class II Peptide Complexes in Immature Human Dendritic Cells

1998 • 64 citations

Stability of empty and peptide-loaded class II major histocompatibility complex molecules at neutral and endosomal pH: Comparison to class I proteins

1997 • 63 citations

The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail

1993 • 58 citations

Dendritic cell maturation and antigen presentation in the absence of invariant chain

1998 • 57 citations

T cell specificity for class II (I-A) and the encephalitogenic N-terminal epitope of the autoantigen myelin basic protein.

1987 • 52 citations

A disease-related epitope of Torpedo acetylcholine receptor. Residues involved in I-Ab binding, self-nonself discrimination, and TCR antagonism.

1994 • 47 citations

Detection of peptide-MHC class II complexes on the surface of intact cells

1990 • 41 citations

Altered peptide ligand modulation of experimental allergic encephalomyelitis: immune responses within the CNS

1998 • 40 citations

I-A alpha polymorphic residues that determine alloreactive T cell recognition.

1989 • 30 citations

DM exchange mechanism

1995 • 23 citations

Production and Characterization of Two New Mouse Monoclonal Antibodies Reactive with Denatured Mouse Class II Beta Chains

1992 • 20 citations

Murine Thy-1+ Dendritic Epidermal T Cell Lines Express Granule-Associated Perforin and a Family of Granzyme Molecules

1992 • 15 citations

Inefficient Peptide Binding by Cell-Surface Class II MHC Molecules

1997 • 15 citations

HLA-DM is expressed on the cell surface and colocalizes with HLA-DR and invariant chain in human Langerhans cell

1998 • 11 citations

A Newly Identified Antigen Retention Compartment in the FSDC Precursor Dendritic Cell Line

1997 • 6 citations

Blood Dendritic Cells Express Detectable Amounts of Class II-related DM Protein on the Cell Surfaces

1996 • 4 citations

Deleted Work

1955 • 0 citations