Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures

1961 • 5,561 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Molecular characterization of proteins in detergent solutions

1974 • 492 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

The Binding of Detergents to Lipophilic and Hydrophilic Proteins

1972 • 357 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

1991 • 234 citations

Differential expression and serologically distinct subpopulations of human Ia antigens detected with monoclonal antibodies to Ia alpha and beta chains

1982 • 183 citations

Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain.

1986 • 162 citations

Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens.

1982 • 155 citations

Invariant chain trimers are sequestered in the rough endoplasmic reticulum in the absence of association with HLA class II antigens.

1990 • 149 citations

High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR.

1990 • 148 citations

Invariant chain targets HLA class II molecules to acidic endosomes containing internalized influenza virus.

1991 • 146 citations

Demonstration of two distinct light chains in HLA‐DR‐associated antigens by two‐dimensional gel electrophoresis

1982 • 91 citations

Monensin prevents terminal glycosylation of the N- and O-linked oligosaccharides of the HLA-DR-associated invariant chain and inhibits its dissociation from the alpha-beta chain complex.

1984 • 90 citations

Invariant chain is the core protein of the Ia-associated chondroitin sulfate proteoglycan.

1985 • 87 citations

Characterization of detergent-solubilized membrane proteins. Hydrodynamic and sedimentation equilibrium properties of the insulin receptor of the cultured human lymphoblastoid cell.

1981 • 43 citations

Identification of a new component in the murine Ia molecular complex.

1983 • 26 citations

Biosynthetic intermediates of HLA class II antigens from B lymphoblastoid cell lines.

1986 • 16 citations