Major histocompatibility class II peptide occupancy, antigen presentation, and CD4+ T cell function in mice lacking the p41 isoform of invariant chain

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles.

1993 • 900 citations

Mice lacking MHC class II molecules

1991 • 869 citations

Assembly, Transport, and Function of MHC Class II Molecules

1994 • 791 citations

Depletion of CD4 ⁺ T Cells in Major Histocompatibility Complex Class II-Deficient Mice

1991 • 673 citations

Monoclonal antibodies to mouse MHC antigens. III. Hybridoma antibodies reacting to antigens of the H-2b haplotype reveal genetic control of isotype expression.

1981 • 581 citations

MHC class II-associated invariant chain contains a sorting signal for endosomal compartments

1990 • 565 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Sequences and Factors: A Guide to MHC Class-II Transcription

1992 • 540 citations

A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication.

1981 • 531 citations

Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon

1983 • 487 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxin

1987 • 451 citations

Altered peptidase and viral-specific T cell response in LMP2 mutant mice

1994 • 450 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune interferon and its effect on antigen presentation.

1985 • 440 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Mice lacking the MHC class II-associated invariant chain

1993 • 385 citations

Introduction of a subtle mutation into the Hox-2.6 locus in embryonic stem cells

1991 • 338 citations

Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression.

1993 • 326 citations

Formation of a nine-subunit complex by HLA class II glycoproteins and the invariant chain

1991 • 326 citations

[51] Gene targeting in embryonic stem cells

1993 • 320 citations

Membrane insertion and oligomeric assembly of HLA-DR histocompatibility antigens

1982 • 308 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

Class II MHC molecules can use the endogenous pathway of antigen presentation

1990 • 271 citations

Proteolysis of the class II-associated invariant chain generates a peptide binding site in intracellular HLA-DR molecules.

1991 • 234 citations

Lectin-induced expression of DR antigen on human cultured follicular thyroid cells

1983 • 233 citations

Efficient cell surface expression of class II MHC molecules in the absence of associated invariant chain.

1986 • 226 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells

1992 • 201 citations

Extensive trafficking of MHC class II-invariant chain complexes in the endocytic pathway and appearance of peptide-loaded class II in multiple compartments

1995 • 198 citations

Invariant chain can function as a chaperone protein for class II major histocompatibility complex molecules.

1992 • 197 citations

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules.

1994 • 196 citations

Isolation of twelve monoclonal antibodies against Ia and H-2 antigens. Serological characterization and reactivity with B and T lymphocytes

1979 • 193 citations

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells.

1984 • 190 citations

Assembly and transport properties of invariant chain trimers and HLA-DR-invariant chain complexes.

1992 • 189 citations

An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells.

1990 • 188 citations

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.

1995 • 186 citations

In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides

1994 • 185 citations

The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy.

1994 • 184 citations

A role of la-associated invariant chains in antigen processing and pressentation

1989 • 184 citations

Differential expression of Ia and Ia-associated invariant chain in mouse tissues after in vivo treatment with IFN-gamma.

1986 • 164 citations

Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain.

1986 • 162 citations

Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture.

1991 • 158 citations

Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules

1993 • 157 citations

Biosynthesis and glycosylation of the invariant chain associated with HLA-DR antigens.

1982 • 155 citations

HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells.

1992 • 148 citations

Primary structure of the gene for the murine Ia antigen-associated invariant chains (Ii). An alternatively spliced exon encodes a cysteine-rich domain highly homologous to a repetitive sequence of thyroglobulin.

1987 • 147 citations

Relationship between invariant chain expression and major histocompatibility complex class II transport into early and late endocytic compartments.

1993 • 146 citations

Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody

1982 • 145 citations

A role for calnexin (IP90) in the assembly of class II MHC molecules.

1994 • 144 citations

Cell surface expression of class II histocompatibility antigens occurs in the absence of the invariant chain.

1986 • 142 citations

Invariant chain influences the immunological recognition of MHC class II molecules

1990 • 127 citations

Antigen presentation enhanced by the alternatively spliced invariant chain gene product p41

1992 • 124 citations

The segment of invariant chain that is critical for association with major histocompatibility complex class II molecules contains the sequence of a peptide eluted from class II polypeptides.

1993 • 123 citations

Mapping functional regions in the lumenal domain of the class II-associated invariant chain.

1994 • 122 citations

Diversity of Endogenous Epitopes Bound to MHC Class II Molecules Limited by Invariant Chain

1994 • 116 citations

Two processing pathways for the MHC class II-restricted presentation of exogenous influenza virus antigen.

1994 • 113 citations

The invariant chain of murine ia antigens: Its glycosylation, abundance and subcellular localization

1981 • 108 citations

Allelic differences affecting invariant chain dependency of MHC class II subunit assembly

1995 • 106 citations

Association with BiP and aggregation of class II MHC molecules synthesized in the absence of invariant chain.

1994 • 104 citations

Stable surface expression of invariant chain prevents peptide presentation by HLA-DR.

1992 • 94 citations

Invariant chain promotes egress of poorly expressed, haplotype-mismatched class II major histocompatibility complex A alpha A beta dimers from the endoplasmic reticulum/cis-Golgi compartment.

1991 • 94 citations

A cell line that can induce thymocyte positive selection

1992 • 91 citations

Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain.

1994 • 87 citations

Four Ia invariant chain forms derive from a single gene by alternate splicing and alternate initiation of transcription/translation.

1987 • 85 citations

Antigen presentation of hen egg‐white lysozyme but not of ribonuclease A is augmented by the major histocompatibility complex class II‐associated invariant chain

1991 • 74 citations

Transport properties of free and MHC class ll-associated oligomers containing different isoforms of human invariant chain

1994 • 69 citations

Differential expression of the invariant chain in mouse tumor cells: relationship to B lymphoid development.

1984 • 66 citations

Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I presentation pathways.

1993 • 65 citations

Efficiency of antigen presentation differs in mice differing at the Mls locus

1983 • 62 citations

Epitope-specific enhancement of antigen presentation by invariant chain.

1993 • 52 citations

Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains.

1991 • 52 citations

Characterization of fragments of the murine Ia-associated invariant chain.

1991 • 49 citations

Unexpected lack of reactivity of allogeneic anti-Ia monoclonal antibodies with MHC class II molecules expressed by mouse intestinal epithelial cells.

1993 • 48 citations

Antigen-specific, H-2-restricted helper T cell hybridomas.

1982 • 44 citations

Three distinct signals can induce class II gene expression in a murine pre-B-cell line.

1986 • 42 citations

Refolding and reassembly of separate alpha and beta chains of class II molecules of the major histocompatibility complex leads to increased peptide-binding capacity.

1990 • 37 citations

Transcriptional control of the invariant chain gene involves promoter and enhancer elements common to and distinct from major histocompatibility complex class II genes.

1990 • 36 citations

T cell clones specific for IgG2a of the a allotype: direct evidence for presentation of endogenous antigen.

1986 • 34 citations

Nonimmune human cells can express MHC class II antigens in the absence of invariant chain--an immunohistological study on normal and chronically inflamed small intestine.

1988 • 34 citations

Poor loading of major histocompatibility complex class II molecules with endogenously synthesized short peptides in the absence of invariant chain

1995 • 32 citations

Formation of complexes between self-peptides and MHC class II molecules in cells defective for presentation of exogenous protein antigens.

1992 • 31 citations

Early events in the assembly of major histocompatibility complex class II heterotrimers from their free subunits

1994 • 28 citations

Deletion of a C-terminal sequence of the class II-associated invariant chain abrogates invariant chains oligomer formation and class II antigen presentation.

1995 • 27 citations

Defective assembly of class I major histocompatibility complex molecules in an embryonic cell line

1991 • 23 citations