Mood disorders: Regulation by metabotropic glutamate receptors

Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report

2006 • 4,724 citations

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

2003 • 4,175 citations

Antidepressant effects of ketamine in depressed patients

2000 • 3,482 citations

A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

2006 • 3,477 citations

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice

2005 • 1,470 citations

Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants

1995 • 1,404 citations

Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus

1997 • 1,105 citations

Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test

2005 • 1,060 citations

Cellular Mechanisms Underlying the Antidepressant Effects of Ketamine: Role of α-Amino-3-Hydroxy-5-Methylisoxazole-4-Propionic Acid Receptors

2007 • 1,050 citations

Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins

1999 • 1,024 citations

Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial

2007 • 1,021 citations

Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

2000 • 880 citations

Perisynaptic Location of Metabotropic Glutamate Receptors mGluR1 and mGluR5 on Dendrites and Dendritic Spines in the Rat Hippocampus

1996 • 845 citations

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

2001 • 678 citations

Metabotropic glutamate receptors

2006 • 595 citations

Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

2005 • 593 citations

Signal transduction, pharmacological properties, and expression patterns of two rat metabotropic glutamate receptors, mGluR3 and mGluR4

1993 • 585 citations

Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat

1993 • 554 citations

Distribution of the mRNA for a metabotropic glutamate receptor (mGluR3) in the rat brain: An in situ hybridization study

1993 • 518 citations

Regulation of Adult Neurogenesis by Antidepressant Treatment

2001 • 446 citations

Glutamate and Depression

2003 • 404 citations

Antidepressants for the new millennium

1999 • 358 citations

Multiple presynaptic metabotropic glutamate receptors modulate excitatory and inhibitory synaptic transmission in hippocampal area CA1

1995 • 354 citations

Potential anxiolytic‐ and antidepressant‐like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

2001 • 311 citations

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

2005 • 308 citations

Group I metabotropic glutamate receptors: implications for brain diseases

1999 • 297 citations

Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex.

2000 • 275 citations

Antidepressant and anxiolytic‐like effects in mice lacking the group III metabotropic glutamate receptor mGluR7

2003 • 257 citations

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity

2003 • 248 citations

Onset and Early Behavioral Effects of Pharmacologically Different Antidepressants and Placebo in Depression

2003 • 241 citations

Adaptation of the N-methyl-D-aspartate receptor complex following chronic antidepressant treatments.

1994 • 241 citations

Effect of zinc supplementation on antidepressant therapy in unipolar depression: a preliminary placebo-controlled study.

2004 • 236 citations

Chronic Antidepressants Reduce Depolarization-Evoked Glutamate Release and Protein Interactions Favoring Formation of SNARE Complex in Hippocampus

2005 • 232 citations

Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac)

2002 • 226 citations

A role for AMPA receptors in mood disorders

2006 • 226 citations

Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs

2007 • 220 citations

Distribution of a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat and mouse: an immunohistochemical study with a monoclonal antibody

1998 • 217 citations

LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress

2003 • 208 citations

The Anticonvulsants Lamotrigine, Riluzole, and Valproate Differentially Regulate AMPA Receptor Membrane Localization: Relationship to Clinical Effects in Mood Disorders

2006 • 206 citations

Depression – emerging insights from neurobiology

2001 • 205 citations

Pharmacological validation of the chronic mild stress model of depression

1996 • 201 citations

The NMDA Receptor as a Therapeutic Target in Major Depressive Disorder

2007 • 200 citations

Two Distinct Signaling Pathways Upregulate NMDA Receptor Responses via Two Distinct Metabotropic Glutamate Receptor Subtypes

2002 • 194 citations

Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests

2006 • 186 citations

Antidepressant-like effects of acute and chronic treatment with zinc in forced swim test and olfactory bulbectomy model in rats

2003 • 170 citations

Zinc and depression. An update.

2005 • 158 citations

Pharmacological manipulation of mGlu2 receptors influences cognitive performance in the rodent

2004 • 158 citations

Metabotropic Glutamate 5 Receptor Antagonism Is Associated with Antidepressant-Like Effects in Mice

2006 • 155 citations

Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats

2002 • 154 citations

Enhanced cocaine responsiveness and impaired motor coordination in metabotropic glutamate receptor subtype 2 knockout mice

2005 • 151 citations

Activation of the mGlu7 receptor elicits antidepressant-like effects in mice

2007 • 144 citations

Chronic AMPA receptor potentiator (LY451646) treatment increases cell proliferation in adult rat hippocampus

2003 • 144 citations

Group II Metabotropic and α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionate (AMPA)/Kainate Glutamate Receptors Regulate the Deficit in Brain Reward Function Associated with Nicotine Withdrawal in Rats

2003 • 142 citations

Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges

2001 • 141 citations

Metabotropic Glutamate Receptors in the Control of Mood Disorders

2007 • 138 citations

Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats

2003 • 131 citations

AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist

2005 • 131 citations

Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist

2005 • 131 citations

An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats

2006 • 130 citations

Long-term potentiation of hippocampal mossy fiber synapses is blocked by postsynaptic injection of calcium chelators

1989 • 125 citations

Heterologous expression of metabotropic glutamate receptors in adult rat sympathetic neurons: Subtype-specific coupling to ion channels

1995 • 123 citations

The Metabotropic Glutamate 5 Receptor Antagonist 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine Reduces Ethanol Self-Administration in Multiple Strains of Alcohol-Preferring Rats and Regulates Olfactory Glutamatergic Systems

2005 • 121 citations

Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039

2004 • 116 citations

AMPA Receptors in the Therapeutic Management of Depression

2007 • 114 citations

Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurons

1999 • 109 citations

Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors

2005 • 108 citations

Psychostimulant withdrawal as an inducing condition in animal models of depression

2005 • 104 citations

Presynaptic inhibitory action of the group II metabotropic glutamate receptor agonists, LY354740 and DCG-IV

1998 • 97 citations

Zinc treatment induces cortical brain-derived neurotrophic factor gene expression

2004 • 71 citations

Activity-dependent presynaptic autoinhibition by group II metabotropic glutamate receptors at the perforant path inputs to the dentate gyrus and CA1

2001 • 70 citations

A metabotropic glutamate 2/3 receptor antagonist, MGS0039, increases extracellular dopamine levels in the nucleus accumbens shell

2005 • 69 citations

Modulation of DOI-induced increases in cortical BDNF expression by group II mGlu receptors

2002 • 67 citations

C″ and Depression

1993 • 66 citations

Neuropharmacological profiles of antagonists of group II metabotropic glutamate receptors

2005 • 66 citations

Effect of acute and chronic administration of citalopram on glutamate and aspartate release in the rat prefrontal cortex.

2001 • 65 citations

Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression.

2002 • 62 citations

Effect of chronic imipramine or electroconvulsive shock on the expression of mGluR1a and mGluR5a immunoreactivity in rat brain hippocampus

2002 • 58 citations

Metabotropic glutamate autoreceptors of the mGlu5 subtype positively modulate neuronal glutamate release in the rat forebrain in vitro

2000 • 58 citations

Targeting Neurotrophic/Growth Factor Expression and Signaling for Antidepressant Drug Development

2007 • 57 citations

Combined administration of PHCCC, a positive allosteric modulator of mGlu4 receptors and ACPT-I, mGlu III receptor agonist evokes antidepressant-like effects in rats

2006 • 57 citations

Chronic treatment with antidepressants affects glycine/NMDA receptor function: behavioral evidence

2000 • 55 citations

Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats.

2003 • 55 citations

Metabotropic glutamate receptor 5 antagonist-induced stimulation of hypothalamic–pituitary–adrenal axis activity: interaction with serotonergic systems

2003 • 54 citations

Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus

2002 • 54 citations

Glutamate release inhibiting properties of the novel mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence

2001 • 49 citations

Antidepressant treatment influences group I of glutamate metabotropic receptors in slices from hippocampal CA1 region

1998 • 41 citations

Effect of MPEP treatment on brain-derived neurotrophic factor gene expression.

2006 • 40 citations

Multiple pathways for regulation of the KCl-induced [3H]-GABA release by metabotropic glutamate receptors, in primary rat cortical cultures

1998 • 37 citations

Blockade of the mGlu5 receptor decreases basal and stress-induced cortical norepinephrine in rodents

2005 • 34 citations

Metabotropic glutamate receptors and neuroadaptation to antidepressants: imipramine‐induced down‐regulation of β‐adrenergic receptors in mice treated with metabotropic glutamate 2/3 receptor ligands

2005 • 31 citations

Citalopram influences mGlu7, but not mGlu4 receptors' expression in the rat brain hippocampus and cortex

2007 • 31 citations

Effect of chronic antidepressant or electroconvulsive shock treatment on mGLuR1a immunoreactivity expression in the rat hippocampus.

2000 • 24 citations

The influence of prolonged antidepressant treatment on the changes in cyclic AMP accumulation induced by excitatory amino acids in rat cerebral cortical slices

1995 • 22 citations

Modulation of GABAergic inhibition in the rat superior colliculus by a presynaptic group II metabotropic glutamate receptor

2006 • 22 citations

The influence of prolonged antidepressant treatment on the changes in cyclic AMP accumulation induced by excitatory amino acids in rat cerebral cortical slices

1995 • 17 citations

Effect of antidepressants on glutamatergic autoregulatory presynaptic mechanism in the rat cerebral cortex

1990 • 15 citations

Antagonism of metabotropic glutamate group II receptors in the potential treatment of neurological and neuropsychiatric disorders

2006 • 12 citations

Noradrenergic lesion antagonizes desipramine-induced adaptation of NMDA receptors

2000 • 8 citations