Citalopram influences mGlu7, but not mGlu4 receptors' expression in the rat brain hippocampus and cortex

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

2006 • 3,477 citations

PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

1997 • 3,070 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

The Excitatory Amino Acid Receptors: Their Classes, Pharmacology, and Distinct Properties in the Function of the Central Nervous System

1989 • 2,203 citations

A Molecular and Cellular Theory of Depression

1997 • 2,091 citations

Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments

1995 • 2,090 citations

Differential Presynaptic Localization of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus

1997 • 1,105 citations

Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

2000 • 880 citations

Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression

2004 • 764 citations

Regulation of Serotonin1A, Glucocorticoid, and Mineralocorticoid Receptor in Rat and Human Hippocampus: Implications for the Neurobiology of Depression

1998 • 694 citations

Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

2001 • 678 citations

Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.

1998 • 621 citations

Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application

2006 • 526 citations

Adaptation of N-Methyl-D-Aspartate (NMDA) Receptors following Antidepressant Treatment: Implications for the Pharmacotherapy of Depression

1996 • 341 citations

Potential anxiolytic‐ and antidepressant‐like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

2001 • 311 citations

Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: A light and electron microscopic study

1998 • 270 citations

Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression

1994 • 270 citations

Antidepressant and anxiolytic‐like effects in mice lacking the group III metabotropic glutamate receptor mGluR7

2003 • 257 citations

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity

2003 • 248 citations

Plasma and platelet excitatory amino acids in psychiatric disorders

1993 • 243 citations

A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo

2005 • 233 citations

Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: A meta-analysis

2006 • 230 citations

Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs

2007 • 220 citations

Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtype-specific antibodies

1996 • 208 citations

Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat

2006 • 200 citations

Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7

2001 • 196 citations

5-HT1A and beyond: the role of serotonin and its receptors in depression and the antidepressant response

2000 • 165 citations

Synthesis and Pharmacological Characterization of Aminocyclopentanetricarboxylic Acids: New Tools to Discriminate between Metabotropic Glutamate Receptor Subtypes

1997 • 142 citations

The NMDA receptor complex

1993 • 139 citations

Metabotropic Glutamate Receptors in the Control of Mood Disorders

2007 • 138 citations

Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715)

1995 • 137 citations

Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats

2003 • 131 citations

Flattening the Corticosterone Rhythm Attenuates 5-HT1A Autoreceptor Function in the Rat: Relevance for Depression

2003 • 93 citations

Behavioural and Neurochemical Effects of Dizocilpine in the Olfactory Bulbectomized Rat Model of Depression

1997 • 90 citations

Effect of chronic antidepressant treatment on transcription factor binding activity in rat hippocampus and frontal cortex

1998 • 72 citations

Human metabotropic glutamate receptor type 7: Molecular cloning and mRNA distribution in the CNS

1996 • 67 citations

Altered Short-Term Synaptic Plasticity in Mice Lacking the Metabotropic Glutamate Receptor mGlu7

2002 • 63 citations

Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression.

2002 • 62 citations

Modulation of NMDA receptors by glycine ? introduction to some basic aspects and recent developments

1998 • 61 citations

Effect of chronic imipramine or electroconvulsive shock on the expression of mGluR1a and mGluR5a immunoreactivity in rat brain hippocampus

2002 • 58 citations

Combined administration of PHCCC, a positive allosteric modulator of mGlu4 receptors and ACPT-I, mGlu III receptor agonist evokes antidepressant-like effects in rats

2006 • 57 citations

Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats.

2003 • 55 citations

Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus

2002 • 54 citations

Glutamate modulators as novel interventions for mood disorders

2005 • 48 citations

Antidepressant treatment influences group I of glutamate metabotropic receptors in slices from hippocampal CA1 region

1998 • 41 citations

The development of our understanding of the mechanism of action of antidepressant drugs.

1991 • 25 citations

The effect of prolonged imipramine and electroconvulsive shock treatment on calcium/calmodulin-dependent protein kinase II in the hippocampus of rat brain

1999 • 23 citations

The influence of prolonged antidepressant treatment on the changes in cyclic AMP accumulation induced by excitatory amino acids in rat cerebral cortical slices

1995 • 22 citations

Are compounds acting at metabotropic glutamate receptors the answer to treating depression?

2006 • 18 citations

The influence of prolonged antidepressant treatment on the changes in cyclic AMP accumulation induced by excitatory amino acids in rat cerebral cortical slices

1995 • 17 citations

Central effects of repeated treatment with CGP 37849, a competitive NMDA receptor antagonist with potential antidepressant activity.

1993 • 15 citations

GlycineB recognition site of NMDA receptors and its antagonists

1998 • 11 citations

Influence of imipramine treatment on the group I of metabotropic glutamate receptors in CA1 region of hippocampus.

1998 • 9 citations

Possible involvement of mGluR1 together with group II and III mGluRs in ibotenate-stimulated cAMP formation in the rat brain cortical slices.

2001 • 6 citations

Effect of some iono- and metabotropic glutamatergic ligands on neuropeptide Y immunoreactivity in the rat hippocampus.

2003 • 4 citations