A role for AMPA receptors in mood disorders

Stress and the brain: from adaptation to disease

2005 • 4,321 citations

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

2003 • 4,175 citations

Cloned Glutamate Receptors

1994 • 3,989 citations

Glutamate receptor ion channels

2005 • 3,667 citations

Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus

2000 • 3,047 citations

Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

Neurotrophins and their receptors: A convergence point for many signalling pathways

2003 • 2,173 citations

A Molecular and Cellular Theory of Depression

1997 • 2,091 citations

Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments

1995 • 2,090 citations

STRESS AND HIPPOCAMPAL PLASTICITY

1999 • 2,023 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

Brain-Derived Neurotrophic Factor Produces Antidepressant Effects in Behavioral Models of Depression

2002 • 1,627 citations

Assessing antidepressant activity in rodents: recent developments and future needs

2002 • 1,525 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus

1995 • 1,429 citations

The many faces of CREB

2005 • 1,282 citations

Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS

1995 • 1,239 citations

Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

1996 • 1,200 citations

The cellular neurobiology of depression

2001 • 1,169 citations

Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders

2001 • 1,136 citations

Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants

2003 • 1,125 citations

AMPA Receptor Trafficking at Excitatory Synapses

2003 • 1,121 citations

Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity

2000 • 1,085 citations

Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain

1996 • 943 citations

Activity dependent regulation of BDNF and NGF mRNAs in the rat hippocampus is mediated by non-NMDA glutamate receptors.

1990 • 899 citations

Mechanisms for Activation and Antagonism of an AMPA-Sensitive Glutamate Receptor

2000 • 870 citations

Altered Gene Expression of Brain-Derived Neurotrophic Factor and Receptor Tyrosine Kinase B in Postmortem Brain of Suicide Subjects

2003 • 831 citations

Characterization of Multiple Phosphorylation Sites on the AMPA Receptor GluR1 Subunit

1996 • 802 citations

trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.

1991 • 785 citations

Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects

2003 • 783 citations

Identification of a Site in Glutamate Receptor Subunits That Controls Calcium Permeability

1991 • 774 citations

Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression

2004 • 764 citations

Stress, Glucocorticoids, and Damage to the Nervous System: The Current State of Confusion

1996 • 737 citations

Control of Kinetic Properties of AMPA Receptor Channels by Nuclear RNA Editing

1994 • 735 citations

Structure of a glutamate-receptor ligand-binding core in complex with kainate

1998 • 672 citations

Mechanism of glutamate receptor desensitization

2002 • 650 citations

Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism

2002 • 569 citations

Antidepressants and neuroplasticity

2002 • 498 citations

Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for Difficult-to-Treat depression

2003 • 494 citations

Naturally Occurring Truncated trkB Receptors Have Dominant Inhibitory Effects on Brain-Derived Neurotrophic Factor Signaling

1996 • 472 citations

Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain

1995 • 470 citations

CREB Couples Neurotrophin Signals to Survival Messages

2000 • 455 citations

Regulation of Adult Neurogenesis by Antidepressant Treatment

2001 • 446 citations

Glutamate and Depression

2003 • 404 citations

Neuropharmacology of AMPA and kainate receptors

1998 • 362 citations

Antidepressants for the new millennium

1999 • 358 citations

AMPA Receptor Flip/Flop Mutants Affecting Deactivation, Desensitization, and Modulation by Cyclothiazide, Aniracetam, and Thiocyanate

1996 • 343 citations

BDNF Promotes the Regenerative Sprouting, But Not Survival, of Injured Serotonergic Axons in the Adult Rat Brain

2000 • 341 citations

The Hypothalamic Neuropeptide Melanin-Concentrating Hormone Acts in the Nucleus Accumbens to Modulate Feeding Behavior and Forced-Swim Performance

2005 • 339 citations

cAMP Response Element-Binding Protein Is Essential for the Upregulation of Brain-Derived Neurotrophic Factor Transcription, But Not the Behavioral or Endocrine Responses to Antidepressant Drugs

2002 • 330 citations

Reduced activation and expression of ERK1/2 MAP kinase in the post‐mortem brain of depressed suicide subjects

2001 • 319 citations

Allosteric potentiation of quisqualate receptors by a nootropic drug aniracetam.

1990 • 303 citations

Experience Strengthening Transmission by Driving AMPA Receptors into Synapses

2003 • 300 citations

Differential Dependence on GluR2 Expression of Three Characteristic Features of AMPA Receptors

1997 • 298 citations

Cyclothiazide differentially modulates desensitization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor splice variants.

1994 • 295 citations

Positive Modulation of AMPA Receptors Increases Neurotrophin Expression by Hippocampal and Cortical Neurons

2000 • 283 citations

BDNF acutely increases tyrosine phosphorylation of the NMDA receptor subunit 2B in cortical and hippocampal postsynaptic densities

1998 • 278 citations

Differential regulation of Brain Derived Neurotrophic Factor transcripts by antidepressant treatments in the adult rat brain

2003 • 274 citations

The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

1999 • 271 citations

Implanted fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat.

1994 • 270 citations

TARP γ-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity

2005 • 268 citations

The role of monoamines in the actions of established and “novel” antidepressant agents: a critical review

2004 • 248 citations

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity

2003 • 248 citations

Stargazin Reduces Desensitization and Slows Deactivation of the AMPA-Type Glutamate Receptors

2005 • 247 citations

Intra- and interstrain differences in models of “behavioral despair”

2001 • 247 citations

The Neurobiology of Mental Illness

2005 • 245 citations

Bi-phasic change in BDNF gene expression following antidepressant drug treatment

2003 • 244 citations

Onset and Early Behavioral Effects of Pharmacologically Different Antidepressants and Placebo in Depression

2003 • 241 citations

Repeated stress increases catalytic TrkB mRNA in rat hippocampus

1999 • 237 citations

Volumetric brain imaging findings in mood disorders

2002 • 235 citations

Regulation of neurotrophin receptors during the maturation of the mammalian visual system

1994 • 233 citations

Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors

2005 • 229 citations

Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioral effects of fluoxetine (Prozac)

2002 • 226 citations

Antidepressant-like actions of an AMPA receptor potentiator (LY392098)

2001 • 221 citations

Volumetric MRI studies of mood disorders: do they distinguish unipolar and bipolar disorder?

2002 • 193 citations

Stress-induced changes in messenger RNA levels of N-methyl-d-aspartate and AMPA receptor subunits in selected regions of the rat hippocampus and hypothalamus

1995 • 185 citations

NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus

2002 • 182 citations

Neurogenesis and depression: etiology or epiphenomenon?

2004 • 182 citations

Stargazin Modulates Native AMPA Receptor Functional Properties by Two Distinct Mechanisms

2005 • 175 citations

Structural determinants of allosteric regulation in alternatively spliced AMPA receptors

1995 • 164 citations

Modulation of Synaptic Plasticity by Antimanic Agents: The Role of AMPA Glutamate Receptor Subunit 1 Synaptic Expression

2004 • 161 citations

Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder

2001 • 145 citations

Chronic AMPA receptor potentiator (LY451646) treatment increases cell proliferation in adult rat hippocampus

2003 • 144 citations

Antidepressant activity of memory-enhancing drugs in the reduction of submissive behavior model

2002 • 136 citations

Current perspectives on the development of non-biogenic amine-based antidepressants

2001 • 133 citations

AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist

2005 • 131 citations

Animal models of depression: are there any?

2003 • 126 citations

An AMPA receptor potentiator modulates hippocampal expression of BDNF: an in vivo study

2002 • 122 citations

Chronic antidepressant treatment increases the membrane expression of AMPA receptors in rat hippocampus

2002 • 122 citations

Anterograde transport of endogenous brain-derived neurotrophic factor in hippocampal mossy fibers

1997 • 119 citations

Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder

2003 • 118 citations

Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039

2004 • 116 citations

DARPP-32 mediates serotonergic neurotransmission in the forebrain

2002 • 116 citations

Effect of Chronic Stress on Synaptic Currents in Rat Hippocampal Dentate Gyrus Neurons

2003 • 110 citations

Administration of a cAMP Phosphodiesterase 4 Inhibitor Enhances Antidepressant-Induction of BDNF mRNA in Rat Hippocampus

2000 • 109 citations

Enhancement of antidepressant potency by a potentiator of AMPA receptors.

2003 • 105 citations

A single social stress-experience alters glutamate receptor-binding in rat hippocampal CA3 area

1993 • 104 citations

A Novel Allosteric Potentiator of AMPA Receptors: 4-[2-(Phenylsulfonylamino)ethylthio]-2,6-Difluoro-Phenoxyacetamide

1997 • 104 citations

Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator

2001 • 104 citations

Neurotrophin modulation of voltage‐gated potassium channels in rat through TrkB receptors is time and sensory experience dependent

2002 • 99 citations

Glutamate receptors in the postmortem striatum of schizophrenic, suicide, and control brains

1997 • 99 citations

Brain-Derived Neurotrophic Factor Acutely Inhibits AMPA-Mediated Currents in Developing Sensory Relay Neurons

2000 • 97 citations

Regulation of cAMP phosphodiesterase mRNAs expression in rat brain by acute and chronic fluoxetine treatment. An in situ hybridization study

2002 • 94 citations

AMPA Receptor Potentiators: Application for Depression and Parkinsons Disease

2007 • 92 citations

LY404187: A Novel Positive Allosteric Modulator of AMPA Receptors

2002 • 90 citations

Acute stress impairs (or induces) synaptic long‐term potentiation (LTP) but does not affect paired‐pulse facilitation in the stratum radiatum of rat hippocampus

1992 • 89 citations

AMPA Receptor Trafficking: A Road Map for Synaptic Plasticity

2003 • 83 citations

Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro

2001 • 79 citations

Cerebellar brain-derived neurotrophic factor-TrkB defect associated with impairment of eyeblink conditioning in Stargazer mutant mice.

1998 • 77 citations

Selective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia

1996 • 76 citations

Cerebellar Brain-Derived Neurotrophic Factor–TrkB Defect Associated with Impairment of Eyeblink Conditioning inStargazerMutant Mice

1998 • 65 citations

Gene expression of two glutamate receptor subunits in response to repeated stress exposure in rat hippocampus.

2000 • 64 citations

Selective increase of AMPA binding to the AMPA/quisqualate receptor in the hippocampus in response to acute stress

1991 • 57 citations

Influence of immobilization stress on the levels of CaMKII and phospho-CaMKII in the rat hippocampus

2004 • 57 citations

AMPA Receptor Potentiators as Novel Antidepressants

2005 • 56 citations

AMPA receptor desensitization modulates synaptic responses induced by repetitive afferent stimulation in hippocampal slices

1998 • 56 citations

Properties of [3H]AMPA Binding in Postmortem Human Brain from Psychotic Subjects and Controls: Increases in Caudate Nucleus Associated with Suicide

1993 • 54 citations

Structurally Dissimilar Antimanic Agents Modulate Synaptic Plasticity by Regulating AMPA Glutamate Receptor Subunit GluR1 Synaptic Expression

2003 • 54 citations

Repeated administration of antidepressants decreases field potentials in rat frontal cortex

2003 • 49 citations

The waveform of synaptic transmission at hippocampal synapses is not determined by AMPA receptor desensitization

1998 • 49 citations

Chronic unpredictable stress alters gene expression in rat single dentate granule cells

2004 • 48 citations

Repeated ECS induces GluR1 mRNA but not NMDAR1A-G mRNA in the rat hippocampus

1996 • 47 citations

Differential modulation of AMPA receptors by cyclothiazide in two types of striatal neurons

2000 • 45 citations

LY503430: Pharmacology, Pharmacokinetics, and Effects in Rodent Models of Parkinson's Disease

2006 • 44 citations

Sustained Increase in Narp Protein Expression Following Repeated Electroconvulsive Seizure

2000 • 42 citations

Effects of single or repeated restraint stress on GluR1 and GluR2 flip and flop mRNA expression in the hippocampal formation

2002 • 37 citations

Molecular Determinants Responsible for Differences in Desensitization Kinetics of AMPA Receptor Splice Variants

2004 • 34 citations

Stimulation of Glutamate Receptors Increases Expression of Brain‐Derived Neurotrophic Factor mRNA in Rat Hippocampus^a

1992 • 33 citations

The AMPA Receptor Potentiator LY404187 Increases Cerebral Glucose Utilization and c-fos Expression in the Rat

2004 • 29 citations

Further postmortem autoradiographic studies of AMPA receptor binding in schizophrenia

2002 • 28 citations

AMPA glutamate receptors and their flip and flop mRIMAs in human hippocampus

1994 • 26 citations

Multiple Molecular Determinants for Allosteric Modulation of Alternatively Spliced AMPA Receptors

2003 • 25 citations

AMPA glutamate receptors and their flip and flop mRNAs in human hippocampus

1994 • 15 citations