Activation of the mGlu7 receptor elicits antidepressant-like effects in mice

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The tail suspension test: A new method for screening antidepressants in mice

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Behavioral despair in mice: a primary screening test for antidepressants.

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PHARMACOLOGY AND FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTORS

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Regulation of Neurotransmitter Release by Metabotropic Glutamate Receptors

2000 • 880 citations

Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression

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Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

2001 • 678 citations

Glutamate and Depression

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Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice

2003 • 387 citations

Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression

2003 • 331 citations

Potential anxiolytic‐ and antidepressant‐like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

2001 • 311 citations

Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: A light and electron microscopic study

1998 • 270 citations

Antidepressant and anxiolytic‐like effects in mice lacking the group III metabotropic glutamate receptor mGluR7

2003 • 257 citations

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity

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Plasma and platelet excitatory amino acids in psychiatric disorders

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A selective metabotropic glutamate receptor 7 agonist: Activation of receptor signaling via an allosteric site modulates stress parameters in vivo

2005 • 233 citations

Chronic Antidepressants Reduce Depolarization-Evoked Glutamate Release and Protein Interactions Favoring Formation of SNARE Complex in Hippocampus

2005 • 232 citations

Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs

2007 • 220 citations

Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7

2001 • 196 citations

Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests

2006 • 186 citations

mGluR7 Is a Metaplastic Switch Controlling Bidirectional Plasticity of Feedforward Inhibition

2005 • 178 citations

siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain

2005 • 157 citations

Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats

2002 • 154 citations

Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats

2003 • 131 citations

Potential antidepressant-like effect of MTEP, a potent and highly selective mGluR5 antagonist

2005 • 131 citations

An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats

2006 • 130 citations

Metabotropic Glutamate Receptor Subtype 7 Ablation Causes Dysregulation of the HPA Axis and Increases Hippocampal BDNF Protein Levels: Implications for Stress-Related Psychiatric Disorders

2005 • 124 citations

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity

2007 • 123 citations

mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082

2006 • 110 citations

Molecular Pharmacology and Therapeutic Prospects of Metabotropic Glutamate Receptor Allosteric Modulators

2005 • 106 citations

Effect of acute and chronic administration of citalopram on glutamate and aspartate release in the rat prefrontal cortex.

2001 • 65 citations

Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats

2002 • 58 citations

Combined administration of PHCCC, a positive allosteric modulator of mGlu4 receptors and ACPT-I, mGlu III receptor agonist evokes antidepressant-like effects in rats

2006 • 57 citations

Anxiolytic- and antidepressant-like effects of group III metabotropic glutamate agonist (1S,3R,4S)-1-aminocyclopentane-1,3,4-tricarboxylic acid (ACPT-I) in rats.

2003 • 55 citations

SM-20220, a Potent Na+/H+ Exchange Inhibitor, Improves Consciousness Recovery and Neurological Outcome Following Transient Cerebral Ischaemia in Gerbils

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Can siRNA Technology Provide the Tools for Gene Therapy of the Future?

2006 • 35 citations

Anxiolytic-like effects of group III mGlu receptor ligands in the hippocampus involve GABAA signaling.

2007 • 35 citations

Intrathecal neostigmine reduces the zymosan-induced inflammatory response in a mouse air pouch model via adrenomedullary activity: Involvement of spinal muscarinic type 2 receptors

2005 • 34 citations

Anxiolytic-like effect of group III mGlu receptor antagonist is serotonin-dependent

2006 • 33 citations

Effects of dofetilide on cardiovascular tissues from normo- and hypertensive rats

2002 • 30 citations

Are compounds acting at metabotropic glutamate receptors the answer to treating depression?

2006 • 18 citations

Effect of antidepressants on glutamatergic autoregulatory presynaptic mechanism in the rat cerebral cortex

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mGluR7 plays a key role in the modulation of anxiety behavior: Evidence from mGluR7-knockout mice and siRNA-induced knockdown in the adult mouse brain

2005 • 3 citations