Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

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2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

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Metabotropic glutamate receptors as novel targets for anxiety and stress disorders

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3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]- pyridine: A Potent and Highly Selective Metabotropic Glutamate Subtype 5 Receptor Antagonist with Anxiolytic Activity

2002 • 396 citations

Potential anxiolytic‐ and antidepressant‐like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

2001 • 311 citations

The Non-competitive Antagonists 2-Methyl-6-(phenylethynyl)pyridine and 7-Hydroxyiminocyclopropan[b]chromen-1a-carboxylic Acid Ethyl Ester Interact with Overlapping Binding Pockets in the Transmembrane Region of Group I Metabotropic Glutamate Receptors

2000 • 263 citations

Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.

2000 • 255 citations

Novel allosteric antagonists shed light on mglu5 receptors and CNS disorders

2001 • 188 citations

Chronic But Not Acute Treatment with a Metabotropic Glutamate 5 Receptor Antagonist Reverses the Akinetic Deficits in a Rat Model of Parkinsonism

2002 • 181 citations

SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5.

1999 • 180 citations

Treatment of Anxiety Using Fenobam (a Nonbenzodiazepine) in a Double-Blind Standard (Diazepam) Placebo-Controlled Study

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The Behavioral Profile of the Potent and Selective mGlu5 Receptor Antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in Rodent Models of Anxiety

2004 • 159 citations

Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats

2002 • 154 citations

Mutational Analysis and Molecular Modeling of the Binding Pocket of the Metabotropic Glutamate 5 Receptor Negative Modulator 2-Methyl-6-(phenylethynyl)-pyridine

2003 • 145 citations

Anxiolytic-like activity of the mGluR5 antagonist MPEPA comparison with diazepam and buspirone

2002 • 145 citations

Influence of the 5-HT2C receptor antagonist, SB-242084, in tests of anxiety

2002 • 139 citations

Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608)

2002 • 139 citations

Positive and negative allosteric modulation of metabotropic glutamate receptors: emerging therapeutic potential

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The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison

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Novel non-benzodiazepine anxiolytics

1983 • 109 citations

Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities

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Scintillation proximity assay of inositol phosphates in cell extracts: High-throughput measurement of G-protein-coupled receptor activation

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Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, d-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice

2004 • 72 citations

Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats

2002 • 58 citations

In the Amygdala Anxiolytic Action of mGlu5 Receptors Antagonist MPEP Involves Neuropeptide Y but not GABAA Signaling

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Identification and characterization of a novel splice variant of the metabotropic glutamate receptor 5 gene in human hippocampus and cerebellum

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In Vitro and in Vivo Metabolism of the Antianxiolytic Agent Fenobam in the Rat

1995 • 19 citations