An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats

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Conditional and unconditional components of post-shock freezing

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Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

1998 • 1,002 citations

Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala

1990 • 806 citations

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Double Dissociation between the Involvement of the Bed Nucleus of the Stria Terminalis and the Central Nucleus of the Amygdala in Startle Increases Produced by Conditioned versus Unconditioned Fear

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Learned helplessness in the rat.

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Decrease in Caudate Glutamatergic Concentrations in Pediatric Obsessive-Compulsive Disorder Patients Taking Paroxetine

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The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction

2002 • 354 citations

Inhibition of cAMP Response Element-Binding Protein or Dynorphin in the Nucleus Accumbens Produces an Antidepressant-Like Effect

2002 • 310 citations

Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.

1998 • 277 citations

The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats.

1999 • 266 citations

Intra-amygdala infusion of the N-methyl-D-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus.

1992 • 256 citations

MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity

2003 • 248 citations

Intra-amygdala infusion of the N-methyl-D-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus.

1992 • 209 citations

LY354740, an mGlu2/3 Receptor Agonist as a Novel Approach to Treat Anxiety/Stress

2003 • 208 citations

Conditional analgesia, defensive freezing, and benzodiazepines.

1988 • 199 citations

Striatal Excitatory Amino Acid Transporter Transcript Expression in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder

2002 • 189 citations

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

2003 • 187 citations

Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle

1993 • 164 citations

Conditional analgesia, defensive freezing, and benzodiazepines.

1988 • 157 citations

Long‐term behavioral and neurochemical effects of chronic stress exposure in rats

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AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist

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Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats

1999 • 129 citations

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Antagonism of endogenous CRH systems attenuates stress-induced freezing behavior in rats

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Prevention of learned helplessness: In vivo correlation with cortical serotonin

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On the role of prefrontal cortex glutamate for the antithetical phenomenology of obsessive compulsive disorder and attention deficit hyperactivity disorder

2001 • 121 citations

Serotonin reuptake inhibitors reduce conditioned fear stress-induced freezing behavior in rats

1996 • 119 citations

Altered Transcript Expression of NMDA Receptor-Associated Postsynaptic Proteins in the Thalamus of Subjects With Schizophrenia

2003 • 117 citations

Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039

2004 • 116 citations

Additivity of neurochemical changes in learned helplessness and imipramine

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Selective serotonin reuptake inhibitor reduces conditioned fear through its effect in the amygdala

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Serotonergic activation reduces defensive freezing in the conditioned fear paradigm

1996 • 104 citations

Reversal of helpless behavior by serotonin uptake blockers in rats

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Anxiolytic-like activity of MGS0039, a potent group II metabotropic glutamate receptor antagonist, in a marble-burying behavior test

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A metabotropic glutamate 2/3 receptor antagonist, MGS0039, increases extracellular dopamine levels in the nucleus accumbens shell

2005 • 69 citations

Learned helplessness induction decreases in vivo cortical serotonin release

1983 • 66 citations

Neuropharmacological profiles of antagonists of group II metabotropic glutamate receptors

2005 • 66 citations

Metabotropic glutamate II receptor agonists in panic disorder: a double blind clinical trial with LY354740

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Synthesis, in Vitro Pharmacology, Structure−Activity Relationships, and Pharmacokinetics of 3-Alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent and Selective Group II Metabotropic Glutamate Receptor Antagonists

2004 • 59 citations

Selective action of (−)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), a group II metabotropic glutamate receptor agonist, on basal and phencyclidine-induced dopamine release in the nucleus accumbens shell

2004 • 55 citations

Effects of a metabotropic glutamate2/3 receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results

2004 • 54 citations

Eustatic sea level fluctuations induced by polar wander

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Imipramine and fluoxetine prevent the stress-induced escape deficits in rats through a distinct mechanism of action

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Effects of ipsapirone and BAY R 1531 on learned helplessness.

1989 • 25 citations

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