Metabotropic glutamate receptor 5 antagonist-induced stimulation of hypothalamic–pituitary–adrenal axis activity: interaction with serotonergic systems

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2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

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Local origins of some GABAergic projections to the paraventricular and supraoptic nuclei of the hypothalamus in the rat

1993 • 326 citations

Control of Serotonergic Function in Medial Prefrontal Cortex by Serotonin-2A Receptors through a Glutamate-Dependent Mechanism

2001 • 317 citations

Potential anxiolytic‐ and antidepressant‐like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

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Physiological antagonism between 5-hydroxytryptamine(2A) and group II metabotropic glutamate receptors in prefrontal cortex.

2000 • 275 citations

Neurotransmitter Regulation of Cellular Activation and Neuropeptide Gene Expression in the Paraventricular Nucleus of the Hypothalamus

2002 • 258 citations

Anxiolytic-like effects of the prototypical metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine in rodents.

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Novel allosteric antagonists shed light on mglu5 receptors and CNS disorders

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Hypothalamic-Pituitary-Adrenocortical Axis Changes in the Rat after Long-Term Treatment with the Reversible Monoamine Oxidase-A Inhibitor Moclobemide

1994 • 174 citations

Differential Regulation of 5-HT1A Receptor-G Protein Interactions in Brain Following Chronic Antidepressant Administration

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Pharmacology of rapid-onset antidepressant treatment strategies.

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A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: reduction in the levels of G(i) and G(o) proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors.

1997 • 148 citations

Anxiolytic-like activity of the mGluR5 antagonist MPEPA comparison with diazepam and buspirone

2002 • 145 citations

[3H]-Methoxymethyl-MTEP and [3H]-Methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor

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Metabotropic glutamate receptor mGluR5 subcellular distribution and developmental expression in hypothalamus

1995 • 134 citations

Desensitization of 5-HT1A Autoreceptors by a Low Chronic Fluoxetine Dose Effect of the Concurrent Administration of WAY-100635

2001 • 111 citations

[³H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine Binding to Metabotropic Glutamate Receptor Subtype 5 in Rodent Brain: In Vitro and in Vivo Characterization

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Long-term fluoxetine treatment decreases 5-HT1A receptor responsivity in obsessive-compulsive disorder

1991 • 105 citations

Serotonin receptors involved in regulation of pituitary-adrenocortical function in rats

1995 • 95 citations

Long-term fluoxetine produces behavioral anxiolytic effects without inhibiting neuroendocrine responses to conditioned stress in rats

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5-HT1A Receptor Function in Normal Subjects on Clinical Doses of Fluoxetine Blunted Temperature and Hormone Responses to Ipsapirone Challenge

1999 • 89 citations

Daily injections of fluoxetine induce dose-dependent desensitization of hypothalamic 5-HT1A receptors: reductions in neuroendocrine responses to 8-OH-DPAT and in levels of Gz and Gi proteins.

1999 • 84 citations

Repeated treatment with antidepressants differentially alters 5-HT1A agonist-stimulated [35S]GTPγS binding in rat brain regions

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Local Integration of Glutamate Signaling in the Hypothalamic Paraventricular Region: Regulation of Glucocorticoid Stress Reponses

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Serotonergic involvement in stress-induced ACTH release

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Evidence That G_z-Proteins Couple to Hypothalamic 5-HT_1AReceptorsIn Vivo

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Changes in the expression of metabotropic glutamate receptor 5 (mGluR5) in the rat hippocampus in an animal model of depression.

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Local Glutamatergic and GABAergic Synaptic Circuits and Metabotropic Glutamate Receptors in the Hypothalamic Paraventricular and Supraoptic Nuclei

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Effects of repeated doses of azapirones on rat brain 5-HT1A receptors and plasma corticosterone levels

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Changes in Rat Serum Corticosterone After Treatment with Metabotropic Glutamate Receptor Agonists or Antagonists

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Serotonin stimulates corticotropin-releasing factor gene expression in the hypothalamic paraventricular nucleus of conscious rats

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Characterization of the Functional Heterologous Desensitization of Hypothalamic 5-HT_1A Receptors after 5-HT_2AReceptor Activation

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Coadministration of 5-hydroxytryptamine(1A) antagonist WAY-100635 prevents fluoxetine-induced desensitization of postsynaptic 5-hydroxytryptamine(1A) receptors in hypothalamus.

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Local Integration of Glutamate Signaling in the Hypothalamic Paraventricular Region: Regulation of Glucocorticoid Stress Reponses

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