Imipramine treatment up-regulates the expression and function of mGlu2/3 metabotropic glutamate receptors in the rat hippocampus

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

The metabotropic glutamate receptors: Structure and functions

1995 • 2,269 citations

The changing landscape of ischaemic brain injury mechanisms

1999 • 1,111 citations

Pharmacological agents acting at subtypes of metabotropic glutamate receptors

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Coupling of Inositol Phospholipid Metabolism with Excitatory Amino Acid Recognition Sites in Rat Hippocampus

1986 • 444 citations

Adaptation of N-Methyl-D-Aspartate (NMDA) Receptors following Antidepressant Treatment: Implications for the Pharmacotherapy of Depression

1996 • 341 citations

Serotonin and Drug-Induced Therapeutic Responses in Major Depression, Obsessive–Compulsive and Panic Disorders

1999 • 279 citations

Antidepressant activity of non-competitive and competitive NMDA receptor antagonists in a chronic mild stress model of depression

1994 • 270 citations

Pharmacology of rapid-onset antidepressant treatment strategies.

2001 • 165 citations

Expression and Coupling to Polyphosphoinositide Hydrolysis of Group I Metabotropic Glutamate Receptors in Early Postnatal and Adult Rat Brain

1997 • 149 citations

Antidepressant treatments in the 21st century

1998 • 124 citations

Imipramine and phenelzine decrease glutamate overflow in the prefrontal cortex—a possible mechanism of neuroprotection in major depression?

2000 • 106 citations

The Novel Metabotropic Glutamate Receptor Agonist 2 R ,4 R -APDC Potentiates Stimulation of Phosphoinositide Hydrolysis in the Rat Hippocampus by 3,5-dihydroxyphenylglycine: Evidence for a Synergistic Interaction Between Group 1 and Group 2 Receptors

1996 • 104 citations

Tricyclic antidepressants block NMDA receptor-mediated synaptic responses and induction of long-term potentiation in rat hippocampal slices

1993 • 101 citations

Involvement of Serotonin and Dopamine in the Mechanism of Action of Novel Antidepressant Drugs

1998 • 96 citations

Adaptation of the NMDA receptor in rat cortex following chronic electroconvulsive shock or imipramine

1993 • 93 citations

Chronic antidepressant treatment facilitates G protein activation of adenylyl cyclase without altering G protein content.

1995 • 78 citations

Regulation of effectors by G-protein α- and βγ-Subunits

1997 • 50 citations

(2 S ,1′ R ,2′ R ,3′ R )-2-(2,3-dicarboxycyclopropyl) glycine positively modulates metabotropic glutamate receptors coupled to polyphosphoinositide hydrolysis in rat hippocampal slices

1994 • 41 citations

(2S,1′R,2′R,3′R)-2-(2,3-Dicarboxycyclopropyl) glycine enhances quisqualate-stimulated inositol phospholipid hydrolysis in hippocampal slices

1993 • 39 citations

Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLCβ1)

2000 • 38 citations

An antidepressant-induced decrease in the responsiveness of hippocampal neurons to group I metabotropic glutamate receptor activation

1999 • 29 citations

New thoughts on the role of the βγ subunit in G protein signal transduction

2000 • 29 citations

Increased adenylyl cyclase type 1 mRNA, but not adenylyl cyclase type 2 in the rat hippocampus following antidepressant treatment

2000 • 26 citations

Effect of chronic antidepressant or electroconvulsive shock treatment on mGLuR1a immunoreactivity expression in the rat hippocampus.

2000 • 24 citations

Ca2+ antagonists effect an antidepressant-like adaptation of the NMDA receptor complex

1993 • 20 citations

Long-term imipramine effects are prevented by NMDA receptor blockade

1993 • 17 citations

Alterations of tubulin function caused by chronic antidepressant treatment in rat brain.

1999 • 14 citations

Differential effects of chronic administration of the antidepressants amitriptyline and rolipram on adenylyl cyclase activity.

1998 • 2 citations