Phosphorylation at Ser-15 and Ser-392 in mutant p53 molecules from human tumors is altered compared to wild-type p53.

p53 Mutations in Human Cancers

1991 • 8,133 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

p53 function and dysfunction

1992 • 1,918 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

p53 mutations in colorectal cancer.

1990 • 1,030 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

Multisite and hierarchal protein phosphorylation

1991 • 419 citations

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen.

1990 • 415 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

p53 mutations, ras mutations, and p53-heat shock 70 protein complexes in human lung carcinoma cell lines.

1991 • 349 citations

p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer.

1992 • 278 citations

The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.

1990 • 277 citations

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression.

1991 • 251 citations

Maintenance of p53 alterations throughout breast cancer progression.

1991 • 244 citations

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1984 • 225 citations

Association of a murine 53,000-dalton phosphoprotein with simian virus 40 large-T antigen in transformed cells

1980 • 222 citations

p53: the ultimate tumor suppressor gene?

1992 • 209 citations

A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization.

1992 • 193 citations

The nuclear serine/threonine protein kinase DNA-PK.

1992 • 192 citations

The p53 tumor suppressor protein, a modulator of cell proliferation.

1992 • 171 citations

Mutant p53 proteins bind DNA abnormally in vitro.

1991 • 166 citations

Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells

1992 • 161 citations

p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis.

1990 • 156 citations

Human Cells Contain a DNA-Activated Protein Kinase that Phosphorylates Simian Virus 40 T Antigen, Mouse p53, and the Human Ku Autoantigen

1990 • 144 citations

Nuclear protein phosphorylation and growth control

1992 • 135 citations

Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme.

1992 • 121 citations

A DNA binding domain is contained in the C-terminus ofwild typep53 protein

1991 • 113 citations

Analysis of p53 mutants for transcriptional activity.

1991 • 106 citations

Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53

1992 • 105 citations

Human wild-type p53 adopts a unique conformational and phosphorylation state in vivo during growth arrest of glioblastoma cells.

1992 • 99 citations

The involvement of oncogenes and tumor suppressor genes in the control of apoptosis

1992 • 99 citations

Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein.

1992 • 96 citations

Association of casein kinase II with immunopurified p53.

1991 • 86 citations

Phosphorylation sites in the amino-terminal region of mouse p53.

1992 • 74 citations

Synthetic phosphopeptides are substrates for casein kinase II

1990 • 72 citations

Cell cycle regulation and the p53 tumor suppressor protein.

1992 • 52 citations

Characterization of Synthetic Peptide Substrates for p34^cdc2 Protein Kinase

1991 • 41 citations

Purification and partial amino acid sequence analysis of the cellular tumour antigen, p53, from mouse SV40-transformed cells.

1983 • 38 citations

Overlap of the p53-responsive element and cAMP-responsive element in the enhancer of human T-cell leukemia virus type I.

1992 • 32 citations

Analysis of p53 Mutants for Transcriptional Activity

1991 • 31 citations

p53 mosaicism with an exon 8 germline mutation in the founder of a cancer-prone pedigree.

1992 • 30 citations

Eukaryotic Cell-Cycle Control

1992 • 20 citations

Permanent expression of p53 in FR 3T3 rat cells but cell cycle-dependent association with large-T antigen in simian virus 40 transformants.

1985 • 17 citations

Cell Cycle Effects of Microinjected Antisense Oligodeoxynucleotides to p34cdc2 Kinasea

1992 • 11 citations

Partial transformation of human tumor cell lines showing defective interaction between unusual p53 gene product and SV40 large-T antigen.

1990 • 10 citations