Activation of the cryptic DNA binding function of mutant forms of p53

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms

1990 • 3,720 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

Amplification of a gene encoding a p53-associated protein in human sarcomas

1992 • 1,959 citations

p53 function and dysfunction

1992 • 1,918 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

The regulation of transcription by phosphorylation

1992 • 1,316 citations

mdm2 expression is induced by wild type p53 activity.

1993 • 1,286 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

Casein kinase 2: An ‘eminence grise’ in cellular regulation?

1990 • 920 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

Regulation of the specific DNA binding function of p53

1992 • 914 citations

UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells.

1984 • 874 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

p53: oncogene or anti-oncogene?

1990 • 812 citations

A transcriptionally active DNA-binding site for human p53 protein complexes.

1992 • 729 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

High levels of p53 protein in UV-irradiated normal human skin.

1993 • 689 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen.

1990 • 415 citations

Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication

1991 • 382 citations

Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding.

1992 • 344 citations

p53-mediated cell death: relationship to cell cycle control.

1993 • 339 citations

Characterization of the human p53 gene.

1986 • 321 citations

Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein.

1992 • 289 citations

The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.

1990 • 277 citations

The p53 protein is an unusually shaped tetramer that binds directly to DNA.

1993 • 252 citations

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

1992 • 234 citations

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1984 • 225 citations

Mammalian p53 can function as a transcription factor in yeast

1992 • 182 citations

Mutant p53 proteins bind DNA abnormally in vitro.

1991 • 166 citations

Oligomerization of oncoprotein p53

1988 • 158 citations

Induction of Sp1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor-dependent proliferation in human erythroleukemia cell line TF-1.

1993 • 151 citations

Human Cells Contain a DNA-Activated Protein Kinase that Phosphorylates Simian Virus 40 T Antigen, Mouse p53, and the Human Ku Autoantigen

1990 • 144 citations

Interaction of heat-shock protein 70 with p53 translated in vitro: evidence for interaction with dimeric p53 and for a role in the regulation of p53 conformation.

1992 • 142 citations

Precise epitope mapping of the murine transformation-associated protein, p53.

1985 • 139 citations

ras-Induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation

1992 • 133 citations

Phosphorylation of the p53 tumour-suppressor protein at three N-terminal sites by a novel casein kinase I-like enzyme.

1992 • 121 citations

Aggregated dnaA protein is dissociated and activated for DNA replication by phospholipase or dnaK protein.

1990 • 119 citations

Phosphorylation of transcriptional factors and cell-cycle-dependent proteins by casein kinase II

1991 • 116 citations

Identification of a Minimal Transforming Domain of p53: Negative Dominance through Abrogation of Sequence-Specific DNA Binding

1992 • 113 citations

Purification of complexes of nuclear oncogene p53 with rat and Escherichia coli heat shock proteins: in vitro dissociation of hsc70 and dnaK from murine p53 by ATP.

1988 • 106 citations

Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53

1992 • 105 citations

p53-Mediated Cell Death: Relationship to Cell Cycle Control

1993 • 98 citations

M‐phase‐specific cdc2 protein kinase phosphorylates the β subunit of casein kinase II and increases casein kinase II activity

1990 • 86 citations

Conserved cysteine residue in the DNA-binding domain of the bovine papillomavirus type 1 E2 protein confers redox regulation of the DNA-binding activity in vitro.

1992 • 80 citations

Human p53 inhibits growth in Schizosaccharomyces pombe.

1992 • 78 citations

Regulating Cell Growth: Casein-kinase-II-dependent Phosphorylation of Nuclear Oncoproteins

1988 • 63 citations

Casein kinase II from Rana temporaria oocytes

1989 • 48 citations

Mammalian p53 can function as a transcription factor in yeast

1992 • 36 citations

Purification of Complexes of Nuclear Oncogene p53 with Rat and Escherichia coli Heat Shock Proteins: In Vitro Dissociation of hsc70 and dnaK from Murine p53 by ATP

1988 • 28 citations

Human p53 Inhibits Growth in Schizosaccharomyces pombe

1992 • 27 citations

OTA panel opens inquiry into patenting of genes

1993 • 3 citations