Human p53 and CDC2Hs genes combine to inhibit the proliferation of Saccharomyces cerevisiae.

A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.

1989 • 8,705 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Methods in yeast genetics

1979 • 7,824 citations

Transformation of intact yeast cells treated with alkali cations

1983 • 7,688 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Sequences That Regulate the Divergent GAL1-GAL10 Promoter in Saccharomyces cerevisiae

1984 • 955 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Conditional inhibition of transformation and of cell proliferation by a temperature-sensitive mutant of p53

1990 • 801 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

An essential G1 function for cyclin-like proteins in yeast

1989 • 574 citations

Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein.

1991 • 544 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins

1984 • 471 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation

1990 • 437 citations

A family of cyclin homologs that control the G1 phase in yeast.

1989 • 416 citations

Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the "hot spot" mutant phenotypes.

1990 • 409 citations

Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2

1990 • 401 citations

Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28.

1985 • 370 citations

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

1990 • 353 citations

A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis

1991 • 310 citations

IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae.

1989 • 251 citations

Regulation of an Enzyme by Phosphorylation at the Active Site

1990 • 246 citations

Microbial Determinations by Flow Cytometry

1979 • 203 citations

Mutant p53 proteins bind DNA abnormally in vitro.

1991 • 166 citations

Dual regulation of the yeast CDC28-p40 protein kinase complex: Cell cycle, pheromone, and nutrient limitation effects

1987 • 166 citations

p53 interacts with p34cdc2 in mammalian cells: implications for cell cycle control and oncogenesis.

1990 • 156 citations

Identification by peptide analysis of the spectrin-binding protein in human erythrocytes

1979 • 148 citations

The CHL 1 (CTF 1) gene product of Saccharomyces cerevisiae is important for chromosome transmission and normal cell cycle progression in G2/M.

1990 • 140 citations

p53 is associated with p34cdc2 in transformed cells.

1990 • 82 citations

Phosphorylation of p53 in normal and simian virus 40-transformed NIH 3T3 cells.

1988 • 77 citations

Dominant negative protein kinase mutations that confer a G1 arrest phenotype.

1988 • 73 citations

Transcription terminator-like element within a Saccharomyces cerevisiae promoter region.

1986 • 55 citations

Evaluation of protein phosphorylation state by a combination of vertical slab gel isoelectric focusing and immunoblotting

1989 • 54 citations

Conservation of function and regulation within the Cdc28/cdc2 protein kinase family: characterization of the human Cdc2Hs protein kinase in Saccharomyces cerevisiae.

1989 • 50 citations

Phosphorylation of p53 in Normal and Simian Virus 40-Transformed NIH 3T3 Cells

1988 • 30 citations