Flexibility: the key to p53 function?

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Introduction to Protein Structure

2012 • 2,404 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Molecular Biology of Prion Diseases

1991 • 1,978 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.

1993 • 406 citations

Simian virus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum

1979 • 349 citations

High-Resolution Structure of the Oligomerization Domain of p53 by Multidimensional NMR

1994 • 300 citations

Tumor suppressor p53: analysis of wild-type and mutant p53 complexes.

1991 • 242 citations

Mutant conformation of p53

1992 • 214 citations

Wild-type p53 adopts a ‘mutant’-like conformation when bound to DNA.

1993 • 199 citations

Interaction of heat-shock protein 70 with p53 translated in vitro: evidence for interaction with dimeric p53 and for a role in the regulation of p53 conformation.

1992 • 142 citations

Temperature-dependent switching between “wild-type” and “mutant” forms of p53-Val135

1990 • 78 citations