Tissue‐specific expression of p53 in transgenic mice is regulated by intron sequences

Molecular cloning: A laboratory manual

1990 • 85,659 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life.

1988 • 1,140 citations

Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs.

1985 • 1,052 citations

Increased expression of mutant forms of p53 oncogene in primary lung cancer

1990 • 1,045 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Introns increase transcriptional efficiency in transgenic mice.

1988 • 733 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Transgenic mice harboring SV40 t-antigen genes develop characteristic brain tumors

1984 • 492 citations

High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene.

1989 • 383 citations

p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors.

1985 • 380 citations

Characterization of enhancer elements in the long terminal repeat of Moloney murine sarcoma virus

1984 • 341 citations

Rearrangements of the cellular p53 gene in erythroleukaemic cells transformed by Friend virus

1985 • 334 citations

Detection of a common feature in several human tumor cell lines--a 53,000-dalton protein.

1981 • 263 citations

SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumours in transgenic mice

1985 • 241 citations

p53 transformation-related protein: Detection by monoclonal antibody in mouse and human cells

1981 • 222 citations

Overproduction of p53 antigen makes established cells highly tumorigenic

1985 • 217 citations

Identification of the p53 protein domain involved in formation of the simian virus 40 large T-antigen-p53 protein complex

1986 • 175 citations

Relationship between simian virus 40 large tumor antigen expression and tumor formation in transgenic mice

1987 • 90 citations

Characterization of human p53 antigens employing primate specific monoclonal antibodies

1983 • 75 citations

Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen

1989 • 29 citations