Life and death by P53

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

p53 function and dysfunction

1992 • 1,918 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

The p53-mdm-2 autoregulatory feedback loop.

1993 • 1,795 citations

p53 Status and the Efficacy of Cancer Therapy in Vivo

1994 • 1,483 citations

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1993 • 1,445 citations

Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

1993 • 1,360 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Functional inactivation of genes by dominant negative mutations

1987 • 1,174 citations

Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles

1992 • 1,117 citations

Identification of p53 as a Sequence-Specific DNA-Binding Protein

1991 • 1,109 citations

Oncogenic forms of p53 inhibit p53-regulated gene expression

1992 • 933 citations

p53-Dependent apoptosis suppresses tumor growth and progression in vivo

1994 • 883 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

p53 functions as a cell cycle control protein in osteosarcomas.

1990 • 774 citations

Modulation of Activity of the Promoter of the Human MDR 1 Gene by Ras and p53

1992 • 735 citations

A p53-Dependent Mouse Spindle Checkpoint

1995 • 668 citations

Structural aspects of the p53 protein in relation to gene evolution.

1990 • 618 citations

Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation

1991 • 617 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Genetic Mechanisms of Tumor Suppression by the Human p53 Gene

1990 • 540 citations

Wild-type p53 binds to the TATA-binding protein and represses transcription.

1992 • 527 citations

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1990 • 502 citations

Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene.

1994 • 465 citations

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

1994 • 450 citations

Sequence-specific transcriptional activation is essential for growth suppression by p53.

1994 • 412 citations

Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

1994 • 407 citations

Inhibition of DNA replication factor RPA by p53

1993 • 380 citations

Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity.

1994 • 333 citations

Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

1992 • 333 citations

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53

1993 • 329 citations

Nuclear Accumulation of p53 Protein Is Mediated by Several Nuclear Localization Signals and Plays a Role in Tumorigenesis

1990 • 328 citations

Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element.

1992 • 328 citations

Characterization of the human p53 gene.

1986 • 321 citations

Role of the p53 tumor suppressor gene in cell cycle arrest and radiosensitivity of Burkitt's lymphoma cell lines.

1993 • 309 citations

High-Resolution Structure of the Oligomerization Domain of p53 by Multidimensional NMR

1994 • 300 citations

Induction of DNA strand breaks associated with apoptosis during treatment of leukemias.

1993 • 292 citations

p53 and DNA polymerase α compete for binding to SV40 T antigen

1987 • 291 citations

Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene

1984 • 269 citations

A proteolytic fragment from the central region of p53 has marked sequence-specific DNA-binding activity when generated from wild-type but not from oncogenic mutant p53 protein.

1993 • 263 citations

In vivo molecular therapy with p53 adenovirus for microscopic residual head and neck squamous carcinoma.

1995 • 262 citations

Meth A fibrosarcoma cells express two transforming mutant p53 species.

1988 • 247 citations

Different Tumor-Derived p53 Mutants Exhibit Distinct Biological Activities

1990 • 245 citations

p53 domains: identification and characterization of two autonomous DNA-binding regions.

1993 • 239 citations

Development and Characterization of Recombinant Adenoviruses Encoding Human p53 for Gene Therapy of Cancer

1994 • 235 citations

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53–deficient mice

1995 • 233 citations

The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen

1989 • 216 citations

Mouse p53 inhibits SV40 origin-dependent DNA replication

1987 • 216 citations

Therapeutic Effect of a Retroviral Wild-Type p53 Expression Vector in an Orthotopic Lung Cancer Model

1994 • 214 citations

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis.

1990 • 207 citations

Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions.

1992 • 200 citations

Growth suppression of human breast cancer cells by the introduction of a wild-type p53 gene.

1991 • 195 citations

A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis

1994 • 195 citations

A C-terminal alpha-helix plus basic region motif is the major structural determinant of p53 tetramerization.

1992 • 193 citations

Use of the two-hybrid system to identify the domain of p53 involved in oligomerization.

1993 • 182 citations

A mutant p53 tumor suppressor protein is a target for peptide-induced CD8+ cytotoxic T-cells.

1993 • 171 citations

Mutant p53 proteins bind DNA abnormally in vitro.

1991 • 166 citations

Modulation of cellular and viral promoters by mutant human p53 proteins found in tumor cells

1992 • 161 citations

Oligomerization of oncoprotein p53

1988 • 158 citations

p53 Domains: Structure, Oligomerization, and Transformation

1994 • 146 citations

Functional domains of wild-type and mutant p53 proteins involved in transcriptional regulation, transdominant inhibition, and transformation suppression.

1993 • 131 citations

Wild-type p53 induces apoptosis in a Burkitt lymphoma (BL) line that carries mutant p53.

1993 • 118 citations

Expression of wild-type p53 is not compatible with continued growth of p53-negative tumor cells.

1991 • 117 citations

Analysis of p53 mutants for transcriptional activity.

1991 • 106 citations

Tumor cells transfected with a bacterial heat-shock gene lose tumorigenicity and induce protection against tumors.

1993 • 98 citations

Tumor suppressor activity of RB and p53 genes in human breast carcinoma cells.

1993 • 97 citations

Two distinct regions of the murine p53 primary amino acid sequence are implicated in stable complex formation with simian virus 40 T antigen

1988 • 92 citations

p53 domains: structure, oligomerization, and transformation.

1994 • 88 citations

A direct effect of activated human p53 on nuclear DNA replication.

1995 • 87 citations

Expression of wild-type p53 in human A673 cells suppresses tumorigenicity but not growth rate.

1991 • 66 citations

Overexpression of wild-type p53 alters growth and differentiation of normal human keratinocytes but not human papillomavirus-expressing cell lines.

1993 • 57 citations

Detection of both mutant and wild-type p53 protein in normal skin fibroblasts and demonstration of a shared 'second hit' on p53 in diverse tumors from a cancer-prone family with Li-Fraumeni syndrome.

1992 • 48 citations

Equal transcription of wild-type and mutant p53 using bicistronic vectors results in the wild-type phenotype.

1994 • 48 citations

The domain of p53 required for binding HPV 16 E6 is separable from the degradation domain.

1995 • 36 citations

Growth suppression mediated by transfection of p53 in Hut292DM human lung cancer cells expressing endogenous wild-type p53 protein.

1992 • 34 citations

The gene for the rat heat-shock cognate, hsc70, can suppress oncogene-mediated transformation.

1992 • 34 citations

Hot-spot p53 mutants interact specifically with two cellular proteins during progression of the cell cycle.

1994 • 30 citations

Inactive p53 mutants may enhance the transcriptional activity of wild-type p53.

1993 • 30 citations

Adenovirus E1b-58 kD antigen binds to p53 during infection of rodent cells: evidence for an N-terminal binding site on p53.

1991 • 27 citations

Effects of exogenous wild-type p53 on a human lung carcinoma cell line with endogenous wild-type p53

1992 • 27 citations

Wild-type p53 suppresses the malignant phenotype in breast cancer cells containing mutant p53 alleles.

1994 • 17 citations

Structural and kinetic analysis of p53-DNA complexes and comparison of human and murine p53.

1995 • 14 citations