The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/Y6.U5]tri-snRNP particle

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

SR proteins: a conserved family of pre-mRNA splicing factors.

1992 • 766 citations

Specific interactions between proteins implicated in splice site selection and regulated alternative splicing

1993 • 741 citations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

1990 • 723 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

Macromolecular Domains within the Cell Nucleus

1993 • 611 citations

U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

1985 • 568 citations

Split genes and RNA splicing

1994 • 562 citations

A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly

1988 • 535 citations

Associations between distinct pre-mRNA splicing components and the cell nucleus.

1991 • 523 citations

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

1994 • 511 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

Messenger RNA Splicing in Yeast: Clues to Why the Spliceosome Is a Ribonucleoprotein

1991 • 433 citations

[9] Specific labeling of 3′ termini of RNA with T4 RNA ligase

1980 • 421 citations

Intron sequences involved in lariat formation during pre-mRNA splicing

1985 • 402 citations

Interactions of small nuclear RNA's with precursor messenger RNA during in vitro splicing

1992 • 367 citations

Cloning and characterization of PSF, a novel pre-mRNA splicing factor.

1993 • 359 citations

The U5 and U6 Small Nuclear RNAs as Active Site Components of the Spliceosome

1993 • 349 citations

Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism.

1994 • 325 citations

The 3′ Splice Site of Pre-Messenger RNA Is Recognized by a Small Nuclear Ribonucleoprotein

1985 • 310 citations

A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding.

1993 • 300 citations

An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway.

1991 • 297 citations

A protein associated with small nuclear ribonucleoprotein particles recognizes the 3′ splice site of premessenger RNA

1986 • 283 citations

A protein that specifically recognizes the 3′ splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein

1986 • 274 citations

Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing.

1992 • 273 citations

In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism

1993 • 272 citations

Localization of pre-mRNA splicing in mammalian nuclei

1994 • 269 citations

SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex.

1994 • 267 citations

Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution.

1991 • 255 citations

Affinity Chromatography of Splicing Complexes: U2, U5, and U4 + U6 Small Nuclear Ribonucleoprotein Particles in the Spliceosome

1986 • 238 citations

Pre-mRNA splicing and the nuclear matrix.

1987 • 220 citations

A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction.

1994 • 217 citations

Primary structure of NuMA, an intranuclear protein that defines a novel pathway for segregation of proteins at mitosis.

1992 • 215 citations

Association of nuclear matrix antigens with exon-containing splicing complexes.

1994 • 214 citations

Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing

1992 • 209 citations

RNA-RNA interactions in the spliceosome: Unraveling the ties that bind

1994 • 208 citations

Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein.

1988 • 188 citations

A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammals.

1993 • 173 citations

Antisense probing of the human U4U6 snRNP with biotinylated 2′-OMe RNA oligonucleotides

1989 • 169 citations

Dynamic association of proteins with the pre-mRNA branch region.

1994 • 155 citations

Thiophosphorylation of U1-70K protein inhibits pre-mRNA splicing

1993 • 152 citations

Immunoaffinity purification of a [U4/U6.U5] tri-snRNP from human cells.

1991 • 148 citations

20S small nuclear ribonucleoprotein U5 shows a surprisingly complex protein composition.

1989 • 148 citations

Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes.

1987 • 143 citations

Cyclic 2′,3′-Phosphates and Nontemplated Nucleotides at the 3′ End of Spliceosomal U6 Small Nuclear RNA's

1992 • 140 citations

Small Nuclear Ribonucleoprotein (RNP) U2 Contains Numerous Additional Proteins and Has a Bipartite RNP Structure Under Splicing Conditions

1993 • 117 citations

Conservation between yeast and man of a protein associated with U5 small nuclear ribonucleoprotein

1989 • 101 citations

U4 small nuclear RNA dissociates from a yeast spliceosome and does not participate in the subsequent splicing reaction.

1991 • 97 citations

Direct interactions between pre-mRNA and six U2 small nuclear ribonucleoproteins during spliceosome assembly.

1994 • 87 citations

Multiple Interactions between the Splicing Substrate and Small Nuclear Ribonucleoproteins in Spliceosomes

1987 • 86 citations

RNA processing : a practical approach

1994 • 86 citations

Nuclear-mitotic apparatus protein: a structuralprotein interface between the nucleoskeleton and RNA splicing.

1994 • 83 citations

RNA travel: Tracks from DNA to cytoplasm

1993 • 82 citations

Identification of a nuclear protein component of interchromatin granules using a monoclonal antibody and immunogold electron microscopy

1984 • 78 citations

Pre-mRNA Splicing and the Nuclear Matrix

1987 • 75 citations

The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome.

1989 • 74 citations

Identification of protein antigens associated with the nuclear matrix and with clusters of interchromatin granules in both interphase and mitotic cells

1987 • 73 citations

3'-end-dependent formation of U6 small nuclear ribonucleoprotein particles in Xenopus laevis oocyte nuclei.

1992 • 68 citations

Interaction of the yeast splicing factor PRP8 with substrate RNA during both steps of splicing

1995 • 67 citations

A normally masked nuclear matrix antigen that appears at mitosis on cytoskeleton filaments adjoining chromosomes, centrioles, and midbodies.

1992 • 63 citations

The B1C8 protein is in the dense assemblies of the nuclear matrix and relocates to the spindle and pericentriolar filaments at mitosis.

1994 • 62 citations

A splicing factor that is inactivated during in vivo heat shock is functionally equivalent to the [U4/U6.U5] triple snRNP-specific proteins.

1992 • 55 citations

A mammalian protein of 220 kDa binds pre-mRNAs in the spliceosome: a potential homologue of the yeast PRP8 protein.

1990 • 55 citations

U4 Small Nuclear RNA Dissociates from a Yeast Spliceosome and Does Not Participate in the Subsequent Splicing Reaction

1991 • 53 citations

Evidence that a nuclear matrix protein participates in premessenger RNA splicing

1989 • 52 citations

Direct Interactions between Pre-mRNA and Six U2 Small Nuclear Ribonucleoproteins during Spliceosome Assembly

1994 • 51 citations

The budding yeast U5 snRNP Prp8 is a highly conserved protein which links RNA splicing with cell cycle progression

1994 • 51 citations

Colocalization of a high molecular mass phosphoprotein of the nuclear matrix (p255) with spliceosomes

1995 • 40 citations

Mammalian U6 small nuclear RNA undergoes 3' end modifications within the spliceosome.

1993 • 39 citations

Cytostellin distributes to nuclear regions enriched with splicing factors

1994 • 34 citations

3′-End-Dependent Formation of U6 Small Nuclear Ribonucleoprotein Particles in Xenopus laevis Oocyte Nuclei

1992 • 33 citations

Monoclonal antibody CC-3 recognizes phosphoproteins in interphase and mitotic cells

1991 • 28 citations

Change in the expression of a nuclear matrix-associated protein is correlated with cellular transformation.

1991 • 24 citations

Mammalian U6 Small Nuclear RNA Undergoes 3' End Modifications within the Spliceosome

1993 • 18 citations

Localization of molecules with restricted patterns of expression in morphogenesis: An immunohistochemical approach

1989 • 12 citations