A protein associated with small nuclear ribonucleoprotein particles recognizes the 3′ splice site of premessenger RNA

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter

1984 • 6,459 citations

SPLICING OF MESSENGER RNA PRECURSORS

1986 • 1,233 citations

Are snRNPs involved in splicing?

1980 • 1,206 citations

Splicing of Messenger RNA Precursors

1984 • 874 citations

REGULATION OF THE SYNTHESIS OF RIBOSOMES AND RIBOSOMAL COMPONENTS

1984 • 847 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation

1986 • 755 citations

The detection of DNA-binding proteins by protein blotting

1980 • 731 citations

Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.

1981 • 725 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro

1983 • 593 citations

U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing

1985 • 568 citations

A mechanism for RNA splicing.

1980 • 553 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs

1986 • 490 citations

Lariat RNA's as Intermediates and Products in the Splicing of Messenger RNA precursors

1984 • 474 citations

SnRNAs, SnRNPs, and RNA Processing

1982 • 458 citations

mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence.

1986 • 455 citations

A multicomponent complex is involved in the splicing of messenger RNA precursors

1985 • 451 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

The 5′ terminus of the RNA moiety of U1 small nuclear ribonucleoprotein particles is required for the splicing of messenger RNA precursors

1984 • 404 citations

Intron sequences involved in lariat formation during pre-mRNA splicing

1985 • 402 citations

Heterogeneous Nuclear Ribonucleoproteins: Role in RNA Splicing

1986 • 399 citations

A single gene from yeast for both nuclear and cytoplasmic polyadenylate-binding proteins: Domain structure and expression

1986 • 389 citations

The structure of mammalian small nuclear ribonucleoproteins. Identification of multiple protein components reactive with anti-(U1)ribonucleoprotein and anti-Sm autoantibodies.

1984 • 371 citations

A Protein of Molecular Weight 78,000 Bound to the Polyadenylate Region of Eukaryotic Messenger RNAs

1973 • 347 citations

Intron splicing: a conserved internal signal in introns of animal pre-mRNAs.

1984 • 342 citations

Yeast mRNA splicing in vitro.

1985 • 337 citations

Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein

1983 • 333 citations

The 3′ Splice Site of Pre-Messenger RNA Is Recognized by a Small Nuclear Ribonucleoprotein

1985 • 310 citations

Nuclear segregation of U2 snRNA requires binding of specific snRNP proteins

1985 • 307 citations

A protein that specifically recognizes the 3′ splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoprotein

1986 • 274 citations

Messenger RNA splicing in vitro: An excised intervening sequence and a potential intermediate

1984 • 262 citations

Splicing of in vitro synthesized messenger RNA precursors in HeLa cell extracts

1983 • 255 citations

Isolation of small nuclear ribonucleoproteins containing U1, U2, U4, U5, and U6 RNAs.

1983 • 245 citations

A small nuclear ribonucleoprotein is required for splicing of adenoviral early RNA sequences.

1981 • 243 citations

Affinity Chromatography of Splicing Complexes: U2, U5, and U4 + U6 Small Nuclear Ribonucleoprotein Particles in the Spliceosome

1986 • 238 citations

Pre-mRNA splicing in vitro requires intact U4/U6 small nuclear ribonucleoprotein

1986 • 222 citations

U1, U2, and U4/U6 small nuclear ribonucleoproteins are required for in vitro splicing but not polyadenylation

1986 • 192 citations

Role of the 3′ splice site consensus sequence in mammalian pre-mRNA splicing

1985 • 184 citations

Structural organization of ribonucleoproteins containing small nuclear RNAs from HeLa cells

1982 • 184 citations

Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing

1985 • 180 citations

Autoantibodies to the U2 small nuclear ribonucleoprotein in a patient with scleroderma-polymyositis overlap syndrome.

1984 • 178 citations

Intron splicing: a conserved internal signal in introns ofDrosophilapre-mRNAs

1985 • 163 citations

Splicing of adenovirus RNA in a cell-free transcription system.

1983 • 159 citations

Isolation and characterization of rabbit anti-m₃^2,2,7G antibodies

1982 • 135 citations

Fractionation and characterization of human small nuclear ribonucleoproteins containing U1 and U2 RNAs.

1983 • 126 citations

Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs

1984 • 98 citations

Primary and secondary structure of U8 small nuclear RNA.

1985 • 94 citations

Ribonucleoprotein Complex Formation During Pre-mRNA Splicing in Vitro

1986 • 93 citations

Characterization of U small nuclear RNA-associated proteins.

1984 • 83 citations

Small Ribonucleoproteins from Eukaryotes: Structures and Roles in RNA Biogenesis

1983 • 75 citations

RNA splicing products formed with isolated fractions from HeLa cells are associated with fast-sedimenting complexes.

1986 • 75 citations

Purification of a protein required for the splicing of pre-mRNA and its separation from the lariat debranching enzyme.

1985 • 72 citations

Accuratein vitrosplicing of human β-globin RNA

1982 • 71 citations

Interaction of R17 Coat Protein With Its RNA Binding Site For Translational Repression

1983 • 69 citations

RNA-protein organization of U1, U5 and U4-U6 small nuclear ribonucleoproteins in HeLa cells

1986 • 62 citations

Splicing of Xenopus laevis ribosomal protein RNAs is inhibited in vivo by antisera to ribonucleoproteins containing U1 small nuclear RNA

1984 • 54 citations

Isolation and characterization of two fractions from HeLa cells required for mRNA splicing in vitro.

1985 • 51 citations

Use of the cytotoxic nuclease alpha-sarcin to identify the binding site on eukaryotic 5 S ribosomal ribonucleic acid for the ribosomal protein L5.

1986 • 51 citations

Accurate and efficient in vitro splicing of purified precursor RNAs specified by early region 2 of the adenovirus 2 genome

1983 • 50 citations

Ribonucleoprotein complex formation during pre-mRNA splicing in vitro.

1986 • 42 citations

Mg²⁺ Induces a Sharp and Reversible Transition in U₁ and U₂ Small Nuclear Ribonucleoprotein Configurations

1984 • 39 citations

A small nuclear ribonucleoprotein is required for splicing of adenoviral early RNA sequences

1981 • 35 citations

Three distinct activities possibly involved in mRNA splicing are found in a nuclear fraction lacking U1 and U2 RNA

1986 • 32 citations

Detection of a cellular polypeptide associated with adenovirus-coded VA RNA using in vitro labeling of proteins cross-linked to RNA

1982 • 31 citations

Mg2+ induces a sharp and reversible transition in U1 and U2 small nuclear ribonucleoprotein configurations.

1984 • 25 citations

Assembly in anin vitrosplicing reaction of a mouse insulin messenger RNA precursor into a 60-40S ribonucleoprotein complex

1986 • 23 citations

Analysis of the RNA structural elements involved in the binding of the transcription factor III A fromXenopus laevis

1986 • 15 citations