An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway.

A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation

1986 • 755 citations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

1990 • 723 citations

Recognition of cap structure in splicing in vitro of mRNA precursors

1984 • 575 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro

1990 • 500 citations

The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites

1990 • 454 citations

A multicomponent complex is involved in the splicing of messenger RNA precursors

1985 • 451 citations

Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro

1985 • 442 citations

Spliceosome assembly in yeast.

1987 • 402 citations

Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing

1989 • 391 citations

Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor.

1989 • 375 citations

A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5′ cleavage site.

1988 • 364 citations

Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae.

1989 • 340 citations

Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing.

1989 • 314 citations

5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements.

1988 • 307 citations

Functions of the Abundant U-snRNPs

1988 • 284 citations

Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes

1986 • 283 citations

An Early Hierarchic Role of U1 Small Nuclear Ribonucleoprotein in Spliceosome Assembly

1988 • 271 citations

Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution.

1991 • 255 citations

RNA binding specificity of hnRNP proteins: a subset bind to the 3′ end of introns.

1988 • 251 citations

The role of the mammalian branchpoint sequence in pre-mRNA splicing.

1988 • 215 citations

Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein.

1988 • 188 citations

Antisense probing of the human U4U6 snRNP with biotinylated 2′-OMe RNA oligonucleotides

1989 • 169 citations

Splice site selection and ribonucleoprotein complex assembly during in vitro pre-mRNA splicing.

1988 • 163 citations

Targeted snRNP depletion reveals an additional role for mammalian U1 snRNP in spliceosome assembly

1990 • 143 citations

Purification and visualization of native spliceosomes

1988 • 121 citations

Presplicing complex formation requires two proteins and U2 snRNP.

1988 • 117 citations

Protein composition of mammalian spliceosomes assembled in vitro.

1990 • 112 citations

The yeast branchpoint sequence is not required for the formation of a stable U1 snRNA-pre-mRNA complex and is recognized in the absence of U2 snRNA.

1991 • 97 citations

Splicing a spliceosomal RNA

1989 • 95 citations

Gel Electrophoretic Isolation of Splicing Complexes Containing U1 Small Nuclear Ribonucleoprotein Particles

1988 • 95 citations

Identification of a functional mammalian spliceosome containing unspliced pre-mRNA.

1988 • 75 citations

U1 Small Nuclear Ribonucleoproteins are Required Early During Spliceosome Assembly

1987 • 35 citations

Splicing factor SF4 is dispensable for the assembly of a functional splicing complex and participates in the subsequent steps of the splicing reaction.

1990 • 29 citations

Identification and Functional Analysis of Mammalian Splicing Factors

1990 • 25 citations

Assemblage of the prespliceosome complex with separated fractions isolated from HeLa cells.

1990 • 17 citations

The Mammalian pre-mRNA Splicing Apparatus

1990 • 17 citations