In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

SV40-transformed simian cells support the replication of early SV40 mutants

1981 • 2,564 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

Variety in the level of gene control in eukaryotic cells

1982 • 772 citations

Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.

1981 • 725 citations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

1990 • 723 citations

Biochemical Mechanisms of Constitutive and Regulated Pre-mRNA Splicing

1991 • 708 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

Associations between distinct pre-mRNA splicing components and the cell nucleus.

1991 • 523 citations

Steps in the processing of Ad2 mRNA: Poly(A)+ Nuclear sequences are conserved and poly(A) addition precedes splicing

1978 • 478 citations

Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies

1992 • 402 citations

Purified lupus antigen la recognizes an oligouridylate stretch common to the 3′ termini of RNA polymerase III transcripts

1984 • 382 citations

Ultrastructural distribution of nuclear ribonucleoproteins as visualized by immunocytochemistry on thin sections.

1984 • 306 citations

The intranuclear location of a herpes simplex virus DNA-binding protein is determined by the status of viral DNA replication

1984 • 305 citations

Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus.

1991 • 300 citations

Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors.

1991 • 239 citations

Inhibition of HeLa cell protein synthesis during adenovirus infection

1979 • 236 citations

Transcription and RNA processing by the DNA tumour viruses

1980 • 228 citations

Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles.

1990 • 225 citations

Pre-mRNA splicing and the nuclear matrix.

1987 • 220 citations

The structure of replicating adenovirus 2 DNA molecules

1977 • 210 citations

Immunoelectron microscopic localization of snRNPs

1984 • 208 citations

Monoclonal antibody characterization of the C proteins of heterogeneous nuclear ribonucleoprotein complexes in vertebrate cells.

1984 • 198 citations

Monoclonal antibodies which recognize native and denatured forms of the adenovirus DNA-binding protein

1983 • 197 citations

ADENOVIRUS E1A PROTEIN PARADIGM VIRAL TRANSACTIVATOR

1989 • 184 citations

Localization and characterization of newly synthesized nuclear RNA in isolated rat hepatocytes

1976 • 184 citations

Small nuclear ribonucleoproteins and heterogeneous nuclear ribonucleoproteins in the amphibian germinal vesicle: loops, spheres, and snurposomes.

1991 • 182 citations

Ribonucleic acid precursors are associated with the chick oviduct nuclear matrix

1982 • 165 citations

Mapping of B cell epitopes on small nuclear ribonucleoproteins that react with human autoantibodies as well as with experimentally-induced mouse monoclonal antibodies.

1989 • 164 citations

Purification of eukaryotic RNA polymerase II by immunoaffinity chromatography. Elution of active enzyme with protein stabilizing agents from a polyol-responsive monoclonal antibody.

1990 • 163 citations

Localization of the adenovirus early region 1B 55-kilodalton protein during lytic infection: association with nuclear viral inclusions requires the early region 4 34-kilodalton protein

1991 • 154 citations

Adenovirus terminal protein mediates both nuclear matrix association and efficient transcription of adenovirus DNA.

1990 • 154 citations

U1 and U2 small nuclear RNAs are present in nuclear speckles.

1992 • 141 citations

Intranuclear localization of snRNP antigens.

1986 • 140 citations

Preservation of specific RNA distribution within the chromatin-depleted nuclear substructure demonstrated by in situ hybridization coupled with biochemical fractionation.

1991 • 139 citations

Adenoviral heterogeneous nuclear RNA is associated with the host nuclear matrix during splicing

1982 • 129 citations

Immunoelectron microscope visualization of nuclear ribonucleoprotein antigens within spread transcription complexes.

1986 • 123 citations

Redistribution of U-snRNPs during mitosis

1986 • 108 citations

Alternative splicing of beta-tropomyosin pre-mRNA: cis-acting elements and cellular factors that block the use of a skeletal muscle exon in nonmuscle cells.

1991 • 98 citations

Distribution of the 70K U1 RNA-associated protein during interphase and mitosis: correlation with other U RNP particles and proteins of the nuclear matrix

1986 • 94 citations

Redistribution of nuclear ribonucleoprotein antigens during herpes simplex virus infection.

1987 • 81 citations

5′-terminal caps of snRNAs are reactive with antibodies specific for 2,2,7-trimethylguanosine in whole cells and nuclear matrices

1984 • 79 citations

Identification of two nuclear subclasses of the adenovirus type 5-encoded DNA-binding protein

1986 • 79 citations

Transcription-dependent localization of U1 and U2 small nuclear ribonucleoproteins at major sites of gene activity in polytene chromosomes

1984 • 77 citations

Ultrastructural localization of transcription sites and of RNA distribution during the cell cycle of synchronized CHO cells

1978 • 73 citations

Two regions of the adenovirus 2 genome specify families of late polysomal RNAs containing common sequences.

1978 • 60 citations

Regulation of Adenovirus Mrna Formation

1986 • 59 citations

Replicating single-stranded adenovirus type 5 DNA molecules accumulate within well-delimited intranuclear areas of lytically infected HeLa cells.

1990 • 49 citations

Distribution of viral RNA molecules during the adenovirus type 5 infectious cycle in HeLa cells

1992 • 48 citations

Analysis by in Situ hybridization and autoradiography of sites of replication and storage of single- and double-stranded adenovirus type 5 DNA in lytically infected HeLa cells

1990 • 47 citations

Species Identification and Genome Mapping of Cytoplasmic Adenovirus Type 2 RNAs Synthesized Late in Infection

1977 • 47 citations

Colocalization of U1 and U2 small nuclear RNPs by immunocytochemistry

1984 • 46 citations

Immunofluorescence Study of the Adenovirus Type 2 Single-Stranded DNA Binding Protein in Infected and Transformed Cells

1977 • 44 citations

Sites of transcription of adenovirus type 5 genomes in relation to early viral DNA replication in infected HeLa cells. A high resolution in situ hybridization and autoradiographical study

1991 • 41 citations

Adenovirus Proteins and Their Messenger RNAs

1979 • 40 citations

Nuclear factor I is specifically targeted to discrete subnuclear sites in adenovirus type 2-infected cells

1992 • 40 citations

A subset of small nuclear ribonucleoprotein particle antigens is a component of the nuclear matrix

1982 • 38 citations

Macromolecular domains containing nuclear protein p107 and U-snRNP protein p28: Further evidence for an in situ nuclear matrix

1986 • 37 citations

Structure and Function of the Adenovirus-2 Genome

1986 • 23 citations