Intron sequences involved in lariat formation during pre-mRNA splicing

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

pEMBL: a new family of single stranded plasmids

1983 • 1,231 citations

Die Molekularbiologie der Tumorviren

1977 • 951 citations

Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes

1980 • 947 citations

Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro

1984 • 761 citations

Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro

1984 • 679 citations

Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes

1983 • 627 citations

Structure of the adenovirus 2 early mRNAs

1978 • 591 citations

Recognition of cap structure in splicing in vitro of mRNA precursors

1984 • 575 citations

Complex splicing patterns of RNAs from the early regions of adenovirus-2

1979 • 560 citations

The chromosomal arrangement of human α-like globin genes: Sequence homology and α-globin gene deletions

1980 • 531 citations

Human β-globin pre-mRNA synthesized in vitro is accurately spliced in xenopus oocyte nuclei

1983 • 500 citations

The structure and evolution of the two nonallelic rat preproinsulin genes

1979 • 500 citations

Lariat RNA's as Intermediates and Products in the Splicing of Messenger RNA precursors

1984 • 474 citations

The Molecular Genetics of Human Hemoglobin

1984 • 420 citations

The sequence of the chromosomal mouse β-globin major gene: Homologies in capping, splicing and poly(A) sites

1978 • 409 citations

Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts

1983 • 396 citations

Lariat structures are in vivo intermediates in yeast pre-mRNA splicing

1984 • 379 citations

A single-base change at a splice site in a β0-thalassemic gene causes abnormal RNA splicing

1982 • 372 citations

Intron splicing: a conserved internal signal in introns of animal pre-mRNAs.

1984 • 342 citations

Point mutations identify the conserved, intron-contained TACTAAC box as an essential splicing signal sequence in yeast

1984 • 339 citations

The evolution and sequence comparison of two recently diverged mouse chromosomal β-globin genes

1979 • 337 citations

A minimal intron length but no specific internal sequence is required for splicing the large rabbit β-globin intron

1984 • 328 citations

Determination of Sequences in RNA

1972 • 314 citations

Abnormal RNA processing due to the exon mutation of βE-globin gene

1982 • 309 citations

Messenger RNA splicing in vitro: An excised intervening sequence and a potential intermediate

1984 • 262 citations

Evidence for the biochemical role of an internal sequence in yeast nuclear mRNA introns: Implications for U1 RNA and metazoan mRNA splicing

1983 • 239 citations

Base substitution in an intervening sequence of a beta+-thalassemic human globin gene.

1981 • 236 citations

β+ Thalassemia: Aberrant splicing results from a single point mutation in an intron

1981 • 235 citations

In vivo splicing products of the rabbit β-globin pre-mRNA

1984 • 209 citations

The primary structure of the human ε-globin gene

1980 • 195 citations

The structure and transcription of four linked rabbit β-like globin genes

1979 • 171 citations

Efficient site-directed mutagenesis by simultaneous use of two primers

1983 • 154 citations

Simple, efficientin vitrosynthesis of capped RNA useful for direct expression of cloned eukaryoti genes

1982 • 152 citations

In vivo characterization of yeast mRNA processing intermediates

1984 • 152 citations

Micro thin-layer techniques for rapid sequence analysis of 32P-labeled RNA: Double digestion and pancreatic ribonuclease analyses

1977 • 135 citations

Substituting an α-helix switches the sequence-specific DNA interactions of a repressor

1984 • 130 citations

DNA tumor viruses (molecular biology of tumor viruses)

1987 • 126 citations

An intron nucleotide sequence variant in a cloned β⁺-thalassaemia globin gene

1981 • 124 citations

The RNA lariat: A new ring to the splicing of mRNA precursors

1984 • 113 citations

A molecular analysis of fushi tarazu, a gene in Drosophila melanogaster that encodes a product affecting embryonic segment number and cell fate

1984 • 96 citations

Methods of DNA and RNA sequencing

1983 • 92 citations

Abnormally spliced messenger RNA in erythroid cells from patients with β+ thalassemia and monkey cells expressing a cloned β+-thalassemic gene

1982 • 91 citations

Deletion loop mutagenesis: a novel method for the construction of point mutations using deletion mutants

1982 • 70 citations

Synthetic donor and acceptor splice sites function in an RNA polymerase B (II) transcription unit.

1984 • 51 citations