The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements

1987 • 1,792 citations

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1989 • 1,414 citations

Cyclosporine

1989 • 1,340 citations

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1989 • 1,087 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

1989 • 667 citations

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.

1984 • 623 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Molecular cloning and overexpression of the human FK506-binding protein FKBP

1990 • 316 citations

Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA).

1988 • 284 citations

Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes.

1989 • 256 citations

Cyclosporin A suppresses the expression of the interleukin 2 gene by inhibiting the binding of lymphocyte-specific factors to the IL-2 enhancer.

1990 • 171 citations

Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein folding

1990 • 160 citations

Complexity of the primary genetic response to mitogenic activation of human T cells.

1989 • 149 citations

Complementary DNA encoding the human T-cell FK506-binding protein, a peptidylprolyl cis-trans isomerase distinct from cyclophilin.

1990 • 120 citations

Inducible nuclear factor binding to the kappa B elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner

1990 • 65 citations

Complexity of the Primary Genetic Response to Mitogenic Activation of Human T Cells

1989 • 50 citations

Identification of multiplecis-elements andtrans-acting factors involved in the induced expresson of human IL-2 gene

1989 • 39 citations

A novel T-cell trans-activator that recognizes a phorbol ester-inducible element of the interleukin-2 promoter.

1990 • 13 citations