Molecular Basis for Developmental Changes in Interleukin-2 Gene Inducibility

Cyclic AMP and the induction of eukaryotic gene transcription.

1988 • 1,041 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREB predicted by its sequence

1989 • 914 citations

The SCID Mouse Mutant: Definition, Characterization, and Potential Uses

1991 • 743 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Developmental Biology of T Cells in T Cell-Receptor Transgenic Mice

1990 • 637 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

Molecular and Cellular Events of T Cell Development

1989 • 466 citations

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn)

1991 • 395 citations

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1991 • 368 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

NF-κB Subunit Regulation in Nontransformed CD4 ⁺ T Lymphocytes

1992 • 322 citations

Identification and distribution of the costimulatory receptor CD28 in the mouse.

1992 • 316 citations

Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1

1989 • 271 citations

Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes

1987 • 248 citations

Activation of interleukin-2 gene transcription via the T-cell surface molecule CD28 is mediated through an NF-kB-like response element

1991 • 194 citations

The kinetics of T cell antigen receptor expression by subgroups of CD4+8+ thymocytes: delineation of CD4+8+3(2+) thymocytes as post-selection intermediates leading to mature T cells.

1991 • 190 citations

Analysis of the AP-1 sites in the IL-2 promoter.

1992 • 179 citations

Cyclosporin A suppresses the expression of the interleukin 2 gene by inhibiting the binding of lymphocyte-specific factors to the IL-2 enhancer.

1990 • 171 citations

The Development of Functionally Responsive T Cells

1992 • 169 citations

Cytokine production by mature and immature CD4-CD8- T cells. Alpha beta-T cell receptor+ CD4-CD8- T cells produce IL-4.

1992 • 167 citations

Intrathymic maturation of murine T lymphocytes from CD8+ precursors.

1989 • 134 citations

Developmental appearance of factors that bind specifically to cis-regulatory sequences of a gene expressed in the sea urchin embryo.

1988 • 119 citations

Delayed thymocyte development induced by augmented expression of p56lck.

1991 • 117 citations

Regulatory anatomy of the murine interleukin-2 gene

1990 • 106 citations

The immunosuppressives FK 506 and cyclosporin A inhibit the generation of protein factors binding to the two purine boxes of the interleukin 2 enhancer

1991 • 99 citations

The functional domains of the murine Thy-1 gene promoter.

1991 • 77 citations

The Jun and Fos Protein Families Are Both Required for Cell Cycle Progression in Fibroblasts

1991 • 74 citations

Signal transduction via CD4, CD8, and CD28 in mature and immature thymocytes. Implications for thymic selection.

1991 • 72 citations

Cytokine production by mature and immature thymocytes.

1991 • 69 citations

Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes

1989 • 60 citations

Nuclear events after activation of CD4+8+ thymocytes.

1990 • 50 citations

Early precursor thymocytes can produce interleukin 2 upon stimulation with calcium ionophore and phorbol ester.

1986 • 48 citations

IL-2 gene inducibility in T cells before T cell receptor expression. Changes in signaling pathways and gene expression requirements during intrathymic maturation.

1990 • 48 citations

IL-2 receptor inducibility is blocked in cortical-type thymocytes.

1988 • 35 citations

Influence of activating stimulus on functional phenotype: interleukin 2 mRNA accumulation differentially induced by ionophore and receptor ligands in subsets of murine T cells.

1988 • 32 citations

The Promoter of the Human Interleukin-2 Gene Contains Two Octamer-Binding Sites and Is Partially Activated by the Expression of Oct-2

1990 • 31 citations

UV-Induced DNA Damage Is an Intermediate Step in UV-Induced Expression of Human Immunodeficiency Virus Type 1, Collagenase, c-fos, and Metallothionein

1989 • 31 citations

Changes in inducibility of IL-2 receptor alpha-chain and T cell-receptor expression during thymocyte differentiation in the mouse.

1989 • 29 citations

Positive selection is an early event in thymocyte differentiation: high TCR expression by cycling immature thymocytes precedes final maturation by several days

1990 • 27 citations

Molecular Indices of Functional Competence in Developing T Cells

1988 • 26 citations

Non‐hormonal burst in the level of cAMP caused by a ‘temperature shock” to mouse thymocytes

1978 • 20 citations

Induction of a Cyclic AMP-Responsive Gene in Living Cells Requires the Nuclear Factor CREB

1991 • 14 citations

Interleukin-1 Synergy with Phosphoinositide Pathway Agonists for Induction of Interleukin-2 Gene Expression: Molecular Basis of Costimulation

1990 • 11 citations

In Vitro Transfection of Fresh Thymocytes and T Cells Shows Subset-Specific Expression of Viral Promoters

1992 • 4 citations