Interleukin 2, 4 and 5 are sequentially produced in mitogen‐stimulated murine spleen cell cultures

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins.

1986 • 7,504 citations

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

1987 • 1,644 citations

Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors

1988 • 1,086 citations

Two types of murine helper T cell clone. II. Delayed-type hypersensitivity is mediated by TH1 clones.

1987 • 966 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter

1986 • 480 citations

Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II

1986 • 405 citations

A functional dichotomy in CD4+ T lymphocytes

1988 • 369 citations

Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness.

1987 • 289 citations

Limiting dilution analysis of proliferative responses in human lymphocyte populations defined by the monoclonal antibody UCHL1: implications for differential CD45 expression in T cell memory formation

1988 • 281 citations

Heterogeneity of human T4+ inducer T cells defined by a monoclonal antibody that delineates two functional subpopulations.

1982 • 265 citations

MRC OX-22, a monoclonal antibody that labels a new subset of T lymphocytes and reacts with the high molecular weight form of the leukocyte-common antigen.

1983 • 243 citations

A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines

1989 • 237 citations

Loss of CD45R (Lp220) represents a post-thymic T cell differentiation event.

1988 • 218 citations

The functionally distinct subpopulations of human CD4+ helper/inducer T lymphocytes defined by anti-CD45R antibodies derive sequentially from a differentiation pathway that is regulated by activation-dependent post-thymic differentiation.

1988 • 213 citations

Cloned, Ia-restricted T cells that do not produce interleukin 4(IL 4)/B cell stimulatory factor 1(BSF-1) fail to help antigen-specific B cells.

1987 • 209 citations

Characterization of T helper 1 and 2 cell subsets in normal mice. Helper T cells responsible for IL-4 and IL-5 production are present as precursors that require priming before they develop into lymphokine-secreting cells.

1988 • 172 citations

Distinct functional phenotypes of cloned Ia-restricted helper T cells.

1985 • 171 citations

Frequencies of IL-2- and IL-4-secreting T cells in naive and antigen-stimulated lymphocyte populations.

1988 • 164 citations

Phenotypic and functional heterogeneity of CD4+ T cells

1988 • 142 citations

Enhanced responsiveness of human memory T cells to CD2 and CD3 receptor‐mediated activation

1989 • 124 citations

Murine CD4+ T cell subsets defined.

1988 • 102 citations

Human T cell subpopulations defined by a monoclonal antibody. I. A small subset is responsible for proliferation to allogeneic cells or to soluble antigens and for helper activity for B cell differentiation.

1982 • 96 citations

Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.

1975 • 94 citations

Organization and structure of the mouse interleukin-2 gene

1984 • 83 citations

Regulation of Ig Class Secretion by Soluble Products of Certain T‐Cell Lines

1984 • 81 citations

Analysis by in situ hybridization of cells expressing mRNA for interleukin 4 in the developing thymus and in peripheral lymphocytes from mice.

1988 • 78 citations

Secretion of IgG₁ induction factor by T cell clones and hybridomas

1985 • 68 citations

Conditions Determining the Generation and Expression of T Helper Cells

1977 • 64 citations

Differential activation of cytokine genes in normal CD4‐bearing T cells is stimulus dependent

1989 • 60 citations

Functional analysis of T cells expressing Ia antigens. I. Demonstration of helper T-cell heterogeneity.

1979 • 60 citations

Phenotypic and functional alteration of CD4+ T cells after antigen stimulation. Resolution of two populations of memory T cells that both secrete interleukin 4.

1989 • 56 citations

Antigen-Specific and Nonspecific Mediators of T Cell/B Cell Cooperation

1975 • 55 citations

Molecular properties and regulation of mRNA expression for murine T cell-replacing factor/IL-5.

1988 • 53 citations

Functionally distinct helper T cells enriched under different culture conditions cooperate with different B cells.

1982 • 40 citations

Inducibility of interleukin-2 RNA expression in individual mature and immature T lymphocytes.

1987 • 35 citations

Influence of activating stimulus on functional phenotype: interleukin 2 mRNA accumulation differentially induced by ionophore and receptor ligands in subsets of murine T cells.

1988 • 32 citations

Limiting Dilution Analysis of Interleukin 2‐Producing Mature T Cells

1988 • 27 citations

Effect of T3 modulation on pokeweed mitogen-induced T cell activation: evidence for an alternative pathway of T cell activation.

1986 • 24 citations

IL 2 production by mitogen-stimulated T cell subsets: helper-precursors are predominantly Lyt-2-.

1983 • 21 citations