Apoptosis in the Heart

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

1995 • 5,971 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Disruption of epithelial cell-matrix interactions induces apoptosis

1994 • 3,167 citations

Social controls on cell survival and cell death

1992 • 2,641 citations

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.

1992 • 2,420 citations

Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 • 1,821 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

1989 • 1,436 citations

Reperfusion injury induces apoptosis in rabbit cardiomyocytes.

1994 • 1,431 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Protection from Fas-Mediated Apoptosis by a Soluble Form of the Fas Molecule

1994 • 1,120 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.

1996 • 1,045 citations

Anchorage dependence, integrins, and apoptosis

1994 • 1,016 citations

Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation

1992 • 685 citations

Calpain: new perspectives in molecular diversity and physiological‐pathological involvement

1994 • 673 citations

Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells

1995 • 608 citations

Widespread long-term gene transfer to mouse skeletal muscles and heart.

1992 • 586 citations

Hypoxia induces apoptosis with enhanced expression of Fas antigen messenger RNA in cultured neonatal rat cardiomyocytes.

1994 • 560 citations

Programmed cell death and Bcl-2 protection in the absence of a nucleus.

1994 • 560 citations

Proteolysis of Fodrin (Non-erythroid Spectrin) during Apoptosis

1995 • 539 citations

Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution.

1995 • 524 citations

Apoptosis-the molecular basis of cell death

1992 • 517 citations

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

1994 • 517 citations

Heat-shock response is associated with enhanced postischemic ventricular recovery.

1988 • 489 citations

Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues.

1994 • 449 citations

Calpain activation in apoptosis

1994 • 445 citations

Upregulation of vascular endothelial growth factor expression induced by myocardial ischaemia: implications for coronary angiogenesis

1994 • 430 citations

Apoptosis: The Molecular Basis of Cell Death

1991 • 425 citations

Dexamethasone-induced apoptosis involves cleavage of DNA to large fragments prior to internucleosomal fragmentation.

1993 • 419 citations

Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion.

1995 • 397 citations

Topoisomerase II-reactive chemotherapeutic drugs induce apoptosis in thymocytes.

1991 • 392 citations

Heat-shock protein induction in rat hearts. A direct correlation between the amount of heat-shock protein induced and the degree of myocardial protection.

1994 • 364 citations

Evidence of cardiocyte apoptosis in myocardium of dogs with chronic heart failure.

1996 • 335 citations

Mechanisms of Apoptosis: Integration of Genetic, Biochemical, and Cellular Indicators

1994 • 320 citations

Identification, purification, and characterization of a calcium-dependent endonuclease (NUC18) from apoptotic rat thymocytes. NUC18 is not histone H2B.

1991 • 301 citations

Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury.

1994 • 285 citations

Calpain inhibition: an overview of its therapeutic potential

1994 • 280 citations

DNA fragmentation of human infarcted myocardial cells demonstrated by the nick end labeling method and DNA agarose gel electrophoresis.

1995 • 271 citations

Growth of the heart in health and disease

1985 • 262 citations

Postreperfusion inflammation: a model for reaction to injury in cardiovascular disease

1994 • 247 citations

Degradation of lamin B1 precedes oligonucleosomal DNA fragmentation in apoptotic thymocytes and isolated thymocyte nuclei.

1995 • 242 citations

Cell death: programmed, apoptosis, necrosis, or other?

1995 • 220 citations

Induction of fos RNA by DNA-damaging agents.

1989 • 209 citations

Direct gene transfer and expression into rat heart in vivo.

1991 • 208 citations

Induction and nuclear accumulation of fos and jun proto-oncogenes in hypoxic cardiac myocytes

1993 • 206 citations

Hypoxia-induced Protein Binding to O2-responsive Sequences on the Tyrosine Hydroxylase Gene

1995 • 199 citations

Immediate-early gene protein expression in neurons undergoing delayed death, but not necrosis, following hypoxic-ischaemic injury to the young rat brain

1994 • 197 citations

Gene expression on acute myocardial stress. Induction by hypoxia, ischemia, reperfusion, hyperthermia and oxidative stress

1995 • 188 citations

Apoptosis in C3H/10T1/2 mouse embryonic cells: evidence for internucleosomal DNA modification in the absence of double-strand cleavage.

1993 • 181 citations

Protein kinase A and AP-1 (c-Fos/JunD) are induced during apoptosis of mouse mammary epithelial cells.

1994 • 180 citations

Programmed Cell Death and Expression of the Protooncogene bcl-2 in Myocytes during Postnatal Maturation of the Heart

1995 • 177 citations

Cytoplasmic Domain of the Ubiquitous Na+/H+ Exchanger NHE1 Can Confer Ca2+ Responsiveness to the Apical Isoform NHE3

1995 • 176 citations

Reperfusion of Rat Heart After Brief Ischemia Induces Proteolysis of Calspectin (Nonerythroid Spectrin or Fodrin) by Calpain

1995 • 170 citations

Fas/Apo-1 (CD95) receptor lacking the intracytoplasmic signaling domain protects tumor cells from Fas-mediated apoptosis.

1996 • 169 citations

The apoptosis endonucleases: cleaning up after cell death?

1994 • 160 citations

Proto-oncogene expression in porcine myocardium subjected to ischemia and reperfusion.

1992 • 154 citations

Growth of the heart in health and disease

1984 • 149 citations

In vivo DNA degradation in thymocytes of γ-irradiated or hydrocortisone-treated rats

1981 • 146 citations

Cells en route to apoptosis are characterized by the upregulation of c‐fos, c‐myc, c‐jun, cdc2, and RB phosphorylation, resembling events of early cell‐cycle traverse

1995 • 144 citations

Apoptosis: Suicide,execution or murder?

1993 • 138 citations

The genetic program of cell death. hypothesis and some applications: Transformation, carcinogenesis, ageing

1982 • 133 citations

Isolation of a novel inducible rat heat-shock protein (HSP70) gene and its expression during ischaemia/hypoxia and heat shock

1994 • 129 citations

Programmed cell death in the absence of c-Fos and c-Jun

1996 • 127 citations

Expression of the human apolipoprotein AI gene fused to the E. coli gene for β‐galactosidase

1986 • 113 citations

Cleavage of DNA to Large Kilobase Pair Fragments Occurs in Some Forms of Necrosis as Well as Apoptosis

1995 • 98 citations

The 1990 Merck Frosst Award. Ischemic and reperfusion injury in the heart. Cellular mechanisms and pharmacological interventions

1991 • 74 citations

Degradation of chromatin in apoptotic cells.

1995 • 69 citations

Calpain is Implicated in Rat Myocardial Injury after Ischemia or Reperfusion

1994 • 69 citations

Properties of some nuclear nucleases of rat thymocytes and their changes in radiation‐induced apoptosis

1993 • 68 citations

The use of flow cytometry for the investigation of cell death

1993 • 66 citations

Acute Myocardial Infarction Leads to Upregulation of the IGF-1 Autocrine System, DNA Replication, and Nuclear Mitotic Division in the Remaining Viable Cardiac Myocytes

1994 • 66 citations

Radiation-Induced Changes in Tissue Nucleic Acids: Release of Soluble Deoxypolynucleotides in the Spleen

1957 • 63 citations

Post-ischemic apoptotic death of rat neonatal cardiomyocytes.

1995 • 58 citations

Effects of Thiol Protease Inhibitors on Fodrin Degradation During Hypoxia in Cultured Myocytes

1993 • 50 citations

A Variant mRNA Species Encoding a Truncated Form of Fas Antigen in the Rat Liver

1994 • 42 citations

Association of high molecular weight DNA fragmentation with apoptotic or non‐apoptotic cell death induced by calcium ionophore

1995 • 34 citations

Characteristics of Rat Thymus Chromatin Degradation Products after Whole-body X-irradiation

1981 • 33 citations

Reperfusion injury: laboratory phenomenon or clinical reality?

1992 • 23 citations

The Role of Calcium Activated Neutral Protease on Myocardial Cell Injury in Hypoxia.

1992 • 20 citations

The lonely failing heart: a case for ECM genes

1995 • 11 citations

The lonely failing heart: a case for ECM genes

1995 • 5 citations