12-Lipoxygenases and 12(S)-HETE: role in cancer metastasis

Inositol phosphates and cell signalling

1989 • 4,058 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

A novel arachidonic acid-selective cytosolic PLA2 contains a Ca2+-dependent translocation domain with homology to PKC and GAP

1991 • 1,709 citations

pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.

1992 • 1,456 citations

Prostaglandin Endoperoxides. Novel Transformations of Arachidonic Acid in Human Platelets

1974 • 1,410 citations

Tumor invasion and metastases--role of the extracellular matrix: Rhoads Memorial Award lecture.

1986 • 1,408 citations

Protein kinase C - a question of specificity

1994 • 958 citations

PECAM-1 (CD31) Cloning and Relation to Adhesion Molecules of the Immunoglobulin Gene Superfamily

1990 • 948 citations

Compilation of vertebrate-encoded transcription factors

1992 • 934 citations

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

1992 • 831 citations

Chapter 1: Interferons (IFNs)

1986 • 793 citations

Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.

1991 • 719 citations

Aspirin and the potential role of prostaglandins in colon cancer.

1992 • 694 citations

Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

1987 • 640 citations

Mammalian lipoxygenases: molecular structures and functions

1992 • 571 citations

Tumor cell autocrine motility factor.

1986 • 539 citations

Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

1988 • 512 citations

The Three-Dimensional Structure of an Arachidonic Acid 15-Lipoxygenase

1993 • 460 citations

Focal adhesion kinase (p125FAK): A point of convergence in the action of neuropeptides, integrins, and oncogenes

1992 • 453 citations

Specific interaction between Lex and Lex Determinants

1989 • 450 citations

Cloning and expression of a cDNA for the human prostanoid FP receptor.

1994 • 386 citations

The Cellular Basis of Site-Specific Tumor Metastasis

1990 • 349 citations

Prostacyclin: A Potent Antimetastatic Agent

1981 • 335 citations

Translocation of 5-lipoxygenase to the membrane in human leukocytes challenged with ionophore A23187.

1988 • 323 citations

Hydroxyeicosatetraenoic acids (HETEs)

1988 • 309 citations

Reduced Risk of Large-Bowel Adenomas Among Aspirin Users

1993 • 301 citations

Integrins and tumor cell dissemination.

1989 • 294 citations

Platelets and cancer metastasis: A causal relationship?

1992 • 289 citations

Lipoxin biosynthesis and its impact in inflammatory and vascular events

1994 • 275 citations

Interactions of tumor cells with vascular endothelial cell monolayers: a model for metastatic invasion.

1979 • 270 citations

cDNA cloning of a mouse prostacyclin receptor. Multiple signaling pathways and expression in thymic medulla

1994 • 255 citations

Epidermal growth factor—induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products

1993 • 255 citations

Involvement of myosin light-chain kinase in endothelial cell retraction.

1990 • 249 citations

Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.

1994 • 244 citations

Adhesion molecules and tumor cell interaction with endothelium and subendothelial matrix

1992 • 232 citations

cDNA cloning, expression, mutagenesis of C-terminal isoleucine, genomic structure, and chromosomal localizations of murine 12-lipoxygenases.

1994 • 226 citations

Cathepsin B: association with plasma membrane in metastatic tumors.

1986 • 222 citations

Cloning of the cDNA for human 5-lipoxygenase.

1988 • 222 citations

Molecular cloning and primary structure of human 15-lipoxygenase

1988 • 214 citations

Molecular cloning and amino acid sequence of human 5-lipoxygenase.

1988 • 213 citations

A primary determinant for lipoxygenase positional specificity

1991 • 202 citations

Regulation of cell movement: the motogenic cytokines

1991 • 199 citations

Organ-preference of metastasis

1990 • 197 citations

Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase.

1990 • 189 citations

Cloning and expression of a cDNA for the human prostanoid IP receptor.

1994 • 187 citations

Cathepsin B and its endogenous inhibitors: the role in tumor malignancy

1990 • 187 citations

Soybean lipoxygenase-1 enzymically forms both (9S)- and (13S)-hydroperoxides from linoleic acid by a pH-dependent mechanism

1989 • 186 citations

Membrane association of cathepsin B can be induced by transfection of human breast epithelial cells with c-Ha-ras oncogene

1994 • 184 citations

The mitogenic effect of 15- and 12-hydroxyeicosatetraenoic acid on endothelial cells may be mediated via diacylglycerol kinase inhibition.

1987 • 181 citations

Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor

1991 • 179 citations

Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid.

1989 • 173 citations

Thrombin-induced gap formation in confluent endothelial cell monolayers in vitro

1983 • 164 citations

Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells.

1993 • 161 citations

Angiogenesis and colonization in the tumor metastatic process: basic and applied advances

1994 • 158 citations

Adhesomes: specific granules containing receptors for laminin, C3bi/fibrinogen, fibronectin, and vitronectin in human polymorphonuclear leukocytes and monocytes.

1989 • 157 citations

Signal Transduction by Interferon-α Through Arachidonic Acid Metabolism

1991 • 155 citations

Plant lipoxygenases

1977 • 152 citations

The molecular biology of mammalian arachidonic acid metabolism

1991 • 151 citations

Arrest and extravasation of B16 amelanotic melanoma in murine lungs. A light and electron microscopic study.

1985 • 148 citations

Age dependence of ischaemic heart syndromes and the contribution of haemostatic deviations

1992 • 146 citations

Cloning and sequence analysis of the cDNA for arachidonate 12-lipoxygenase of porcine leukocytes.

1990 • 145 citations

Platelets and Cancer Metastasis: More Than an Epiphenomenon

1992 • 145 citations

Interactions between cancer cells and the microvasculature: a rate-regulator for metastasis

1989 • 144 citations

Modulation of the epidermal growth factor mitogenic response by metabolites of linoleic and arachidonic acid in Syrian hamster embryo fibroblasts. Differential effects in tumor suppressor gene (+) and (-) phenotypes.

1992 • 133 citations

Isolation and characterization of a cDNA clone encoding rat 5-lipoxygenase.

1988 • 132 citations

Endogenous 12(S)-HETE production by tumor cells and its role in metastasis.

1994 • 131 citations

Specific action of the lipoxygenase pathway in mediating angiotensin II-induced aldosterone synthesis in isolated adrenal glomerulosa cells.

1987 • 130 citations

Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis

1994 • 123 citations

Enhanced tumor cell adhesion to the subendothelial matrix resulting from 12(S)‐HETE‐induced endothelial cell retraction

1989 • 122 citations

Lipoxygenase metabolites of arachidonic and linoleic acids modulate the adhesion of tumor cells to endothelium via regulation of protein kinase C.

1991 • 121 citations

Biology of the protein kinase C family

1989 • 120 citations

Arachidonate metabolism via lipoxygenase and 12L-hydroperoxy-5,8,10,14-icosatetraenoic acid peroxidase sensitive to anti-inflammatory drugs.

1980 • 118 citations

Arachidonate 12-lipoxygenase of porcine leukocyte with activity for 5-hydroxyeicosatetraenoic acid

1982 • 118 citations

Cloning of the cDNA for human 12-lipoxygenase.

1990 • 117 citations

In vivo efficacy of a novel inhibitor of selected signal transduction pathways including calcium, arachidonate, and inositol phosphates.

1992 • 116 citations

Leukotriene B4 and 12-Hydroxyeicosatetraenoic Acid Stimulate Epidermal Proliferation In Vivo in the Guinea Pig

1985 • 115 citations

Tumor cell-derived 12(S)-hydroxyeicosatetraenoic acid induces microvascular endothelial cell retraction.

1994 • 115 citations

Molecular cloning of a 12‐lipoxygenase cDNA from rat brain

1993 • 115 citations

12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.

1995 • 112 citations

12(S)-HETE Enhancement of Prostate Tumor Cell Invasion: Selective Role of PKC

1994 • 109 citations

Tumor promoter-induced membrane-bound protein kinase C regulates hematogenous metastasis.

1988 • 107 citations

Two immunologically and catalytically distinct arachidonate 12-lipoxygenases of bovine platelets and leukocytes

1988 • 105 citations

A Lipoxygenase Metabolite, 12-(S)-HETE, Stimulates Protein Kinase C-Mediated Release of Cathepsin B from Malignant Cells

1994 • 105 citations

Stereospecific inhibition of PGH2-induced platelet aggregation by lipoxygenase products of icosaenoic acids

1983 • 105 citations

Cytoplasmic dye transfer between metastatic tumor cells and vascular endothelium.

1991 • 103 citations

The complete sequence of the rabbit erythroid cell-specific 15-lipoxygenase mRNA: comparison of the predicted amino acid sequence of the erythrocyte lipoxygenase with other lipoxygenases

1989 • 103 citations

The antiproliferative and antimetastatic compound L651582 inhibits muscarinic acetylcholine receptor-stimulated calcium influx and arachidonic acid release.

1991 • 100 citations

Regulation of Ras-GAP and the Neurofibromatosis-1 Gene Product by Eicosanoids

1991 • 100 citations

On singular or dual positional specificity of lipoxygenases. The number of chiral products varies with alignment of methylene groups at the active site of the enzyme.

1990 • 98 citations

The lipoxygenase metabolite 12(S)‐hete induces a cytoskeleton‐dependent increase in surface expression of integrin α_iibβ₃ on melanoma cells

1991 • 97 citations

Molecular Biology in the Eicosanoid Field

1993 • 96 citations

Leukotriene formation by a purified reticulocyte lipoxygenase enzyme. Conversion of arachidonic acid and 15-hydroperoxyeicosatetraenoic acid to 14, 15-leukotriene A4.

1985 • 95 citations

Characterization of an 8-lipoxygenase activity induced by the phorbol ester tumor promoter 12-O-tetradecanoylphorbol-13-acetate in mouse skin in vivo

1991 • 92 citations

Characterization of human 12-lipoxygenase genes.

1992 • 91 citations

Methionine sulfoxide formation: the cause of self‐inactivation of reticulocyte lipoxygenase

1984 • 87 citations

Mutagenesis of some conserved residues in human 5-lipoxygenase: effects on enzyme activity.

1992 • 86 citations

Identification of PECAM-1 in solid tumor cells and its potential involvement in tumor cell adhesion to endothelium.

1993 • 86 citations

12 -Hydroxyeicosatetraenoic acid plays a central role in the regulation of platelet activation

1991 • 84 citations

Arachidonate 12-lipoxygenase of platelet-type in human epidermal cells

1993 • 83 citations

Arachidonic Acid Metabolites in bFGF-, PDGF-, and Serum-Stimulated Vascular Cell Growth

1994 • 83 citations

Catalytic properties of human platelet 12-lipoxygenase as compared with the enzymes of other origins

1991 • 80 citations

Eicosanoid forming enzyme mRNA in human tissues. Analysis by quantitative polymerase chain reaction

1991 • 79 citations

Regulation of melanoma‐cell motility by the lipoxygenase metabolite 12‐(S)‐hete

1993 • 75 citations

Tumor and host molecules important in the organ preference of metastasis.

1991 • 74 citations

Enzyme-bound pentadienyl and peroxyl radicals in purple lipoxygenase

1990 • 73 citations

Arachidonic acid release from diacylglycerol in human neutrophils. Translocation of diacylglycerol-deacylating enzyme activities from an intracellular pool to plasma membrane upon cell activation

1991 • 72 citations

Spreading of HeLa cells on a collagen substratum requires a second messenger formed by the lipoxygenase metabolism of arachidonic acid released by collagen receptor clustering.

1992 • 71 citations

Requirement for diacylglycerol and protein kinase C in HeLa cell-substratum adhesion and their feedback amplification of arachidonic acid production for optimum cell spreading.

1993 • 71 citations

Identification of a novel arachidonate 12-lipoxygenase in bovine tracheal epithelial cells distinct from leukocyte and platelet forms of the enzyme.

1990 • 70 citations

Downregulation of human platelet reactivity by neutrophils. Participation of lipoxygenase derivatives and adhesive proteins.

1993 • 69 citations

Autocrine motility factor induces differential 12-lipoxygenase expression and activity in high- and low-metastatic K1735 melanoma cell variants.

1994 • 68 citations

Epidermal Growth Factor Enhances a Microsomal 12 — Lipoxygenase Activity in A431 Cells

1993 • 67 citations

12(S)‐hete promotes tumor‐cell adhesion by increasing surface expression of α_Vβ₃ integrins on endothelial cells

1993 • 67 citations

Structure‐function properties of human platelet 12‐lipoxygenase: chimeric enzyme and in vitro mutagenesis studies

1993 • 67 citations

Biosynthesis of 12(S)-hydroxyeicosatetraenoic acid by B16 amelanotic melanoma cells is a determinant of their metastatic potential.

1994 • 66 citations

Enhanced Endothelial Cell Retraction Mediated by 12(S)-HETE: A Proposed Mechanism for the Role of Platelets in Tumor Cell Metastasis

1994 • 66 citations

The lipoxygenase metabolite 12(S)‐hete promotes α_llbβ₃integrin‐mediated tumor‐cell spreading on fibronectin

1992 • 64 citations

Identification of the alpha IIb beta 3 integrin in murine tumor cells.

1992 • 64 citations

New directions in cancer therapy based on aberrant expression of glycosphingolipids: anti-adhesion and ortho-signaling therapy.

1991 • 63 citations

12‐Lipoxygenase, 12(S)‐HETE, and Cancer Metastasis^a

1994 • 61 citations

Kinetic analysis of the induction period in lipoxygenase catalysis

1993 • 61 citations

Induction of arachidonate 12-lipoxygenase mRNA by epidermal growth factor in A431 cells.

1993 • 61 citations

Activation of microvascular endothelium by eicosanoid 12(S)-hydroxyeicosatetraenoic acid leads to enhanced tumor cell adhesion via up-regulation of surface expression of alpha v beta 3 integrin: a posttranscriptional, protein kinase C- and cytoskeleton-dependent process.

1994 • 61 citations

Calcium Induces Membrane Translocation of 12-Lipoxygenase in Rat Platelets

1989 • 60 citations

Evaluation of the role of conserved His and Met residues among lipoxygenases by site-directed mutagenesis of recombinant human 5-lipoxygenase.

1991 • 59 citations

Epidermal growth factor enhances a microsomal 12-lipoxygenase activity in A431 cells.

1992 • 59 citations

Expression of four protein kinase C isoforms in rat fibroblasts. Differential alterations in ras-, src-, and fos-transformed cells.

1992 • 58 citations

Autocrine Motility Factor Is a Growth Factor

1993 • 58 citations

Cancer cell interactions with injured or activated endothelium

1992 • 57 citations

The Lipoxygenase Metabolite, 12(S)-HETE, Induces a Protein Kinase C-Dependent Cytoskeletal Rearrangement and Retraction of Microvascular Endothelial Cells

1993 • 57 citations

Protein kinase C-dependent effects of 12(S)-HETE on endothelial cell vitronectin receptor and fibronectin receptor.

1993 • 57 citations

12-Hydroxyeicosatetraenoic acid reduces prostacyclin production by endothelial cells

1986 • 56 citations

Fatty acid modulation of tumor cell adhesion to microvessel endothelium and experimental metastasis

1992 • 56 citations

Activity and protein distribution of 12-lipoxygenase in HEL cells: Induction of membrane-association by phorbol ester TPA, modulation of activity by glutathione and 13-HPODE, and Ca2+-dependent translocation to membranes

1993 • 55 citations

A cryptic, microsomal-type arachidonate 12-lipoxygenase is tonically inactivated by oxidation-reduction conditions in cultured epithelial cells.

1993 • 53 citations

Fatty acid modulation of tumor cell-platelet-vessel wall interaction

1992 • 51 citations

Transmembrane signaling in human polymorphonuclear neutrophils: 15(S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid modulates receptor agonist-triggered cell activation.

1993 • 51 citations

Structure and chromosomal localization of human arachidonate 12-lipoxygenase gene.

1992 • 49 citations

Increased expression of α_IIb β₃ integrin in subpopulations of murine melanoma cells with high lung‐colonizing ability

1992 • 48 citations

Rat 12-Lipoxygenase: Mutations of Amino Acids Implicated in the Positional Specificity of 15- and 12-Lipoxygenase

1993 • 48 citations

The promoter structure and complete sequence of the gene encoding the rabbit erythroid cell-specific 15-lipoxygenase

1989 • 47 citations

Eicosanoid biosynthesis and action: novel opportunities for pharmacological intervention

1989 • 46 citations

Inhibition of endothelial cell retraction by ATP depletion.

1988 • 46 citations

Protein‐kinase‐C inhibitor calphostin C reduces B16 amelanotic melanoma cell adhesion to endothelium and lung colonization

1992 • 46 citations

PKC mediates 12(S)‐HETE‐induced cytoskeletal rearrangement in B16A melanoma cells

1993 • 45 citations

Role of specific isoforms of protein kinase C in angiotensin II and lipoxygenase action in rat adrenal glomerulosa cells

1994 • 43 citations

12(S)-HETE-induced microvascular endothelial cell retraction results from PKC-dependent rearrangement of cytoskeletal elements and αVβ3 integrins

1993 • 43 citations

Translocation of phospholipase A2 from cytosol to membranes induced by 1-oleoyl-2-acetyl-glycerol in serum-free cultured macrophages

1987 • 42 citations

Prostaglandin Inhibitors in Tumor Immunology and Immunotherapy

2024 • 41 citations

Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Radiation Injury

1993 • 39 citations

Endothelial cell proliferation may be mediated VIA the production of endogenous lipoxygenase metabolites

1987 • 39 citations

X‐Ray absorption spectroscopic studies on iron in soybean lipoxygenase: A model for mammalian lipoxygenases

1990 • 38 citations

Oxygenation of trans polyunsaturated fatty acids by lipoxygenase reveals steric features of the catalytic mechanism

1987 • 37 citations

Endothelium and underlying membrane reactivity with platelets, leukocytes and tumor cells: Regulation by the lipoxygenase-derived fatty acid metabolites, 13-HODE and HETES

1988 • 37 citations

12-HETE inhibits the binding of PGH2/TxA2 receptor ligands in human platelets

1991 • 37 citations

Molecular structure and function of the porcine arachidonate 12-lipoxygenase gene.

1992 • 36 citations

High-Affinity Binding and Lack of Growth-Promoting Activity of 12(S)-Hydroxyeicosatetraenoic Acid (12(S)-HETE) in a Human Epidermal Cell Line

1990 • 36 citations

Is there a role for the tumor cell integrin ?IIb?3 and cytoskeleton in tumor cell-platelet interaction?

1992 • 36 citations

Classification of prostanoid receptors.

1990 • 35 citations

13-Hydroxyoctadecadienoic Acid (13-HODE) Reverses Epidermal Hyperproliferation via Selective Inhibition of Protein Kinase C-β Activity

1994 • 35 citations

The positional specificity of wheat lipoxygenase; the carboxylic group as signal for the recognition of the site of the hydrogen removal

1985 • 33 citations

Measurement of eicosanoids in menstrual fluid by the combined use of high pressure chromatography and radioimmunoassay

1993 • 32 citations

High‐affinity binding sites for 12(S)‐hydroxy‐5,8,10,14‐eicosatetraenoic acid (12(S)‐HETE) in carcinoma cells

1992 • 29 citations

Interferon signalling through arachidonic acid-dependent pathways: A clue to adjuvant therapy for chronic viral hepatitis? Hannigan GE, Williams BRG. Signal transduction by interferon-α through arachidonic metabolism. Science 1991;251:204–207

1991 • 28 citations

Evidence for cytokine regulation of cholesterol metabolism in herpesvirus-infected arterial cells by the lipoxygenase pathway.

1990 • 27 citations

Pentane formation during the anaerobic reactions of reticulocyte lipoxygenase

1984 • 27 citations

Invasion and metastasis: new approaches to an old problem.

1993 • 27 citations

Eicosanoid production by intrauterine tissues before and after labor in short-term tissue culture

1993 • 26 citations

Molecular evolution of cyclooxygenase and lipoxygenase

1992 • 26 citations

Peroxidase-like activity of lipoxygenases: different substrate specificity of potato 5-lipoxygenase and soybean 15-lipoxygenase and particular affinity of vitamin E derivatives for the 5-lipoxygenase

1991 • 25 citations

Evidence for an essential methionine residue in lipoxygenase

1976 • 24 citations

Effects of gamma irradiation on cultured rat and mouse microvessel endothelial cells: metastatic tumor cell adhesion, subendothelial matrix degradation, and secretion of tumor cell growth factors

1991 • 24 citations

Keto fatty acids not containing doubly allylic methylenes are lipoxygenase substrates

1991 • 23 citations

Mechanisms of Neutrophil Migration across Endothelium

1992 • 22 citations

Lipoxygenase products induce neutrophil activation and increase endothelial permeability after thrombin-induced pulmonary microembolism.

1989 • 22 citations

Porcine leukocyte 5‐ and 12‐lipoxygenases are iron enzymes

1991 • 22 citations

Arachidonic acid metabolism of cytosolic fractions of Lewis lung carcinoma cells.

1991 • 22 citations

Regulation of tumor cell adhesion by intracellular 13-HODE: 15-HETE ratio.

1990 • 17 citations

Induction of cyclooxygenase and suppression of 12-lipoxygenase in human erythroleukemia cells upon phorbol ester-induced differentiation

1993 • 17 citations

Arachidonic acid, a growth signal in murine P815 mastocytoma cells.

1993 • 16 citations

MODIFICATION OF LIPOXYGENASE BY HYDROGEN PEROXIDE AND PHOTOOXIDATION

1977 • 13 citations

The effect of glycosyl inositol‐phosphate on cAMP production in isolated rat fat‐cells is transduced by a pertussis toxin sensitive G‐protein

1991 • 11 citations

Effects of 12-Hydroxyeicosatetraenoic Acid on Release of Cathepsin B and Cysteine Proteinase Inhibitors from Malignant Melanoma Cells

1991 • 11 citations

On the mechanistic reasons for the dual positional specificity of the reticulocyte lipoxygenase

1991 • 10 citations

A role for arachidonic acid and its metabolites in the regulation of p21ras activity.

1991 • 10 citations

12(S)-Hete-Induced Microvascular Endothelial Cell Retraction is Mediated by Cytoskeletal Rearrangement Dependent on PKC Activation

1993 • 8 citations

12-Lipoxygenase Products Are Potent Inhibitors of Prostacyclin-Induced Renin Release

1990 • 7 citations

The expression of active human reticulocyte 15-lipoxygenase in bacteria.

1990 • 6 citations

Control of Tumor Cell Induced Endothelial Cell Retraction by Lipoxygenase Metabolites, Prostacyclin and Prostacyclin Analogues

1991 • 6 citations

Polymerase chain reaction cloning and expression of eicosanoid metabolizing enzymes from blood cells.

1991 • 6 citations

In vitro studies on the invasion of blood vessel wall by choriocarcinoma cells.

1989 • 4 citations

Brain Metabolism, “Ferrin,” and Non‐Carbohydrate Oxidation

1993 • 4 citations

Epidermal Growth Factor Regulation of Linoleic Acid Metabolism in Syrian Hamster Embryo Fibroblasts

1993 • 3 citations