Receptor-mediated activation of phospholipase A2 via GTP-binding proteins: arachidonic acid and its metabolites as second messengers

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

Prostaglandins and Thromboxanes

1978 • 1,310 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

How is the level of free arachidonic acid controlled in mammalian cells?

1982 • 1,193 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Cloning and expression of human lipocortin, a phospholipase A2 inhibitor with potential anti-inflammatory activity

1986 • 671 citations

Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells

1987 • 640 citations

Cyclic GMP Metabolism and Involvement in Biological Regulation

1977 • 629 citations

Biochemical actions of hormones

1987 • 588 citations

Islet-activating protein, pertussis toxin: a probe for functions of the inhibitory guanine nucleotide regulatory component of adenylate cyclase

1984 • 567 citations

Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

1984 • 498 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

The regulation of lipomodulin, a phospholipase inhibitory protein, in rabbit neutrophils by phosphorylation.

1981 • 424 citations

ADP-ribosylation of transducin by pertussis toxin blocks the light-stimulated hydrolysis of GTP and cGMP in retinal photoreceptors.

1984 • 327 citations

Intracellular Ca2+ mobilization by arachidonic acid. Comparison with myo-inositol 1,4,5-trisphosphate in isolated pancreatic islets.

1986 • 310 citations

Inhibition by islet-activating protein of a chemotactic peptide-induced early breakdown of inositol phospholipids and Ca2+ mobilization in guinea pig neutrophils.

1985 • 250 citations

Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets.

1986 • 196 citations

Light activation of phospholipase A2 in rod outer segments of bovine retina and its modulation by GTP-binding proteins.

1987 • 186 citations

Basic mechanisms of the epilepsies: Molecular and cellular approaches

1987 • 186 citations

Model for Leukocyte Regulation by Chemoattractant Receptors: Roles of a Guanine Nucleotide Regulatory Protein and Polyphosphoinositide Metabolism

1986 • 181 citations

G proteins as regulators of ion channel function

1987 • 175 citations

A novel mechanism for the inhibition of adenylate cyclase via inhibitory GTP-binding proteins. Calmodulin-dependent inhibition of the cyclase catalyst by the beta gamma-subunits of GTP-binding proteins.

1987 • 161 citations

Identification and purification of sheep platelet phospholipase A2 isoforms. Activation by physiologic concentrations of calcium ion.

1986 • 147 citations

Activation of alpha 1-adrenoceptors, protein kinase C, or treatment with intracellular free Ca2+ elevating agents increases pineal phospholipase A2 activity. Evidence that protein kinase C may participate in Ca2+-dependent alpha 1-adrenergic stimulation of pineal phospholipase A2 activity.

1987 • 140 citations

Identification and isolation of a mammalian protein which is antigenically and functionally related to the phospholipase A2 stimulatory peptide melittin.

1987 • 136 citations

Alpha 1-adrenergic receptor-mediated phosphoinositide hydrolysis and prostaglandin E2 formation in Madin-Darby canine kidney cells. Possible parallel activation of phospholipase C and phospholipase A2.

1987 • 120 citations

Basic mechanisms of the epilepsies. Molecular and cellular approaches.

1986 • 93 citations

Interaction of Brain Synaptic Vesicles Induced by Endogenous Ca ²⁺ -Dependent Phospholipase A ₂

1982 • 92 citations

Alpha 1-adrenergic stimulation of arachidonic acid release and metabolism in a rat thyroid cell line. Mediation of cell replication by prostaglandin E2.

1986 • 89 citations

Receptor-activation of phospholipase A2 in cellular signalling

1987 • 87 citations

Receptor regulation: evidence for a relationship between phospholipid metabolism and neurotransmitter receptor-mediated cAMP formation in brain

1987 • 70 citations

Foundation for the future.

1955 • 64 citations

The kinetics of the phospholipase A2-catalyzed hydrolysis of Egg phosphatidylcholine in unilamellar vesicles. Product inhibition and its relief by serum albumin.

1981 • 61 citations

Arachidonic acid stimulates phosphoinositide hydrolysis and human placental lactogen release in an enriched fraction of placental cells.

1985 • 51 citations

Guanine Nucleotides Stimulate Arachidonic Acid Release by Phospholipase A2 in Saponin-Permeabilized Human Platelets1

1987 • 49 citations

Coordinate actions of arachidonic acid and protein kinase C in gonadotropin-releasing hormone-stimulated secretion of luteinizing hormone

1986 • 48 citations

Prostaglandins and the synergism between VIP and noradrenaline in the cerebral cortex

1987 • 45 citations

Selective regulation by pertussis toxin of insulin-induced activation of particulate cAMP phosphodiesterase activity in 3T3-L1 adipocytes

1983 • 41 citations

Interactions between the muscarinic receptors, sodium channels, and guanine nucleotide-binding protein(s) in rat atria.

1986 • 34 citations

Gravitational radiation from a solid-crust neutron star

1985 • 31 citations

Prostaglandins increase GTP hydrolysis by membranes from human mononuclear cells.

1980 • 27 citations

Stimulation of cyclic nucleotide phosphodiesterase by products of phosphatidylinositol metabolism catalyzed by phospholipase A2

1982 • 20 citations