Cellular Concomitants of Multidrug Resistance

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil.

1981 • 1,463 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

1985 • 843 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells.

1979 • 484 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

1986 • 461 citations

Metaphase Chromosome Anomaly: Association with Drug Resistance and Cell-Specific Products

1976 • 396 citations

Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes.

1979 • 376 citations

Molecular Actions and Targets for Cancer Chemotherapeutic Agents

1981 • 361 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1984 • 340 citations

Role of epidermal growth factor in carcinogenesis.

1986 • 330 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

Vinblastine photoaffinity labeling of a high molecular weight surface membrane glycoprotein specific for multidrug-resistant cells.

1986 • 290 citations

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

1986 • 255 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells.

1986 • 226 citations

Relation of Folic Acid Reductase to Amethopterin Resistance in Cultured Mammalian Cells

1961 • 210 citations

Alteration of plasma membrane glycopeptides and gangliosides of Chinese hamster cells accompanying development of resistance to daunorubicin and vincristine.

1983 • 146 citations

A 22-kd protein (sorcin/V19) encoded by an amplified gene in multidrug-resistant cells, is homologous to the calcium-binding light chain of calpain.

1986 • 137 citations

Increased synthesis of a low molecular weight protein in vincristine-resistant cells

1981 • 121 citations

Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells.

1981 • 114 citations

Cellular resistance to daunomycin in Chinese hamster cells in vitro.

1971 • 113 citations

Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines.

1986 • 113 citations

Membrane-Mediated Drug Resistance and Phenotypic Reversion to Normal Growth Behavior of Chinese Hamster Cells 2

1975 • 106 citations

Drug resistance in Chinese hamster lung and mouse tumor cells.

1983 • 105 citations

Gene amplification-associated cytogenetic aberrations and protein changes in vincristine-resistant Chinese hamster, mouse, and human cells.

1985 • 100 citations

Increased epidermal growth factor receptor in multidrug‐resistant human neuroblastoma cells

1988 • 98 citations

Reversal of Vinca alkaloid resistance but not multiple drug resistance in human leukemic cells by verapamil.

1986 • 96 citations

Amplification of Dihydrofolate Reductase Genes in Methotrexate-resistant Cultured Mouse Cells

1978 • 93 citations

Specifically altered metaphase chromosomes in antifolate-resistant Chinese hamster cells that overproduce dihydrofolate reductase

1980 • 88 citations

Alterations in cell surface membranes in chinese hamster lung cells resistant to adriamycin

1982 • 84 citations

Specific DNA sequence amplification in human neuroblastoma cells.

1983 • 72 citations

Plasma membrane proteins and glycoproteins from chinese hamster cells sensitive and resistant to actinomycin D

1978 • 66 citations

Epidermal growth factor receptor is increased in multidrug-resistant Chinese hamster and mouse tumor cells.

1986 • 65 citations

The development of resistance to methotrexate in a mouse melanoma cell line

1979 • 63 citations

Identification of a novel calcium‐binding protein (CP₂₂) in multidrug‐resistant murine and hamster cells

1986 • 53 citations

Drug response, dihydrofolate reductase, and cytogenetics of amethopterin-resistant Chinese hamster cells in vitro.

1972 • 52 citations

Verapamil hypersensitivity of vincristine resistant Chinese hamster ovary cell lines

1986 • 51 citations

Chromosomes and Cancer: From Molecules to Man

1983 • 45 citations

Specific karyotypic alterations in colchicine-resistant cells

1981 • 42 citations

SOME BIOCHEMICAL PROPERTIES OF CHINESE HAMSTER CELLS SENSITIVE AND RESISTANT TO ACTINOMYCIN D

1974 • 39 citations

Chromosomal localization of three genes coamplified in the multidrug-resistant CHRC5 Chinese hamster ovary cell line.

1987 • 38 citations

Gene amplification accompanies low level increases in the activity of dihydrofolate reductase in antifolate-resistant Chinese hamster lung cells containing abnormally banding chromosomes.

1982 • 33 citations

Rational basis for chemotherapy

1982 • 33 citations

Resistance to actinomycin D and to vincristine induced in a SEWA mouse tumor cell line with concomitant appearance of double minutes and a low molecular weight protein

1984 • 29 citations

Selection of Chromosomal Variant in Amethopterin-Resistant Sublines of Leukemia L1210 With Increased Levels of Dihydrofolate Reductase<xref ref-type="fn" rid="FN2">2</xref>

1963 • 25 citations

Multistep change in epidermal growth factor receptors during spontaneous neoplastic progression in Chinese hamster embryo fibroblasts.

1985 • 23 citations

Gene amplification in Djungarian hamster cell lines possessing decreased plasma membrane permeability for colchicine and some other drugs

1985 • 23 citations

Ganglioside composition of malignant and actinomycin D-resistant nonmalignant Chinese hamster cells

1979 • 16 citations

Hyperproduction of a specific protein in cells resistant to colchicine and adriablastin

1983 • 6 citations