The multidrug transporter, a double-edged sword.

A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants

1976 • 3,228 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells

1986 • 1,903 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

Detection of P-glycoprotein in multidrug-resistant cell lines by monoclonal antibodies

1985 • 927 citations

Isolation and expression of a complementary DNA that confers multidrug resistance

1986 • 808 citations

A family of related ATP-binding subunits coupled to many distinct biological processes in bacteria

1986 • 753 citations

Cellular resistance to actinomycin D in Chinese hamster cells in vitro: cross-resistance, radioautographic, and cytogenetic studies.

1970 • 752 citations

Active outward transport of daunomycin in resistant ehrlich ascites tumor cells

1973 • 729 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance

1986 • 680 citations

Human Multidrug-Resistant Cell Lines: Increased mdr 1 Expression Can Precede Gene Amplification

1986 • 604 citations

Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.

1987 • 538 citations

Isolation and genetic characterization of human KB cell lines resistant to multiple drugs

1985 • 517 citations

A retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells.

1988 • 489 citations

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

1988 • 480 citations

Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts.

1979 • 478 citations

Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins.

1986 • 461 citations

Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines.

1985 • 441 citations

An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdr1 (P-glycoprotein) gene

1988 • 430 citations

Physical-chemical properties shared by compounds that modulate multidrug resistance in human leukemic cells.

1988 • 417 citations

The mdrl gene, responsible for multidrug-resistance, codes for P-glycoprotein

1986 • 410 citations

Genetic and biochemical characterization of multidrug resistance

1985 • 405 citations

The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation.

1987 • 384 citations

Membrane vesicles from multidrug-resistant human cancer cells contain a specific 150- to 170-kDa protein detected by photoaffinity labeling.

1986 • 342 citations

Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase.

1988 • 340 citations

Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells

1984 • 340 citations

Multidrug Resistance1

1988 • 321 citations

Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.

1986 • 312 citations

Amplification and Expression of Genes Associated with Multidrug Resistance in Mammalian Cells

1986 • 293 citations

Isolation and sequence of the promoter region of the human multidrug-resistance (P-glycoprotein) gene.

1987 • 289 citations

The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver.

1987 • 283 citations

Expression of the Multidrug-Resistant Gene in Hepatocarcinogenesis and Regenerating Rat Liver

1987 • 274 citations

The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus.

1988 • 270 citations

Cloning and characterization of a second member of the mouse mdr gene family.

1988 • 268 citations

Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line.

1986 • 253 citations

Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.

1987 • 225 citations

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

1988 • 211 citations

ATP‐binding properties of P glycoprotein from multidrug‐resistant KB cells

1987 • 207 citations

CHO mutants resistant to colchicine, colcemid or griseofulvin have an altered β-tubulin

1980 • 201 citations

Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug-resistant tumor cells: effects of verapamil, trifluoperazine, and phorbol esters.

1987 • 198 citations

Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas.

1987 • 196 citations

Amplification of DNA sequences in human multidrug-resistant KB carcinoma cells.

1985 • 176 citations

Characterization of acquired epipodophyllotoxin resistance in a Chinese hamster ovary cell line: loss of drug-stimulated DNA cleavage activity.

1986 • 165 citations

Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

1987 • 156 citations

Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines.

1988 • 154 citations

A monoclonal antibody-Pseudomonas toxin conjugate that specifically kills multidrug-resistant cells.

1987 • 147 citations

Action of calcium antagonists on multidrug resistant cells

1987 • 144 citations

Genetics of multidrug resistance.

1988 • 118 citations

Differential amplification and disproportionate expression of five genes in three multidrug-resistant Chinese hamster lung cell lines.

1986 • 113 citations

Induction by verapamil of a rapid increase in ATP consumption in multidrug‐resistant tumor cells

1988 • 109 citations

Retroviral transfer of a murine cDNA for multidrug resistance confers pleiotropic drug resistance to cells without prior drug selection.

1988 • 107 citations

Distinct P-glycoprotein precursors are overproduced in independently isolated drug-resistant cell lines.

1988 • 99 citations

Localization of multidrug resistance-associated DNA sequences to human chromosome 7

1986 • 88 citations

Simultaneous expression of two P-glycoprotein genes in drug-sensitive Chinese hamster ovary cells.

1987 • 84 citations

Promoter-glutathione S-transferase Ya cDNA hybrid genes. Expression and conferred resistance to an alkylating molecule in mammalian cells.

1987 • 48 citations

Expression of the mdr (P-glycoprotein) Gene in Chinese Hamster Digestive Tracts1

1988 • 42 citations