Differential regulation and properties of MAPKs

Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases

2002 • 4,097 citations

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

2001 • 3,295 citations

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1994 • 3,285 citations

A central role for JNK in obesity and insulin resistance

2002 • 3,225 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Protein Tyrosine Phosphatases in the Human Genome

2004 • 1,842 citations

Signal Transduction through MAP Kinase Cascades

1998 • 1,762 citations

The c-Jun NH2-terminal Kinase Promotes Insulin Resistance during Association with Insulin Receptor Substrate-1 and Phosphorylation of Ser307

2000 • 1,423 citations

The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions

2006 • 1,247 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

Coordinating ERK/MAPK signalling through scaffolds and inhibitors

2005 • 1,039 citations

Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds

2001 • 808 citations

A conserved docking motif in MAP kinases common to substrates, activators and regulators

2000 • 801 citations

TNF-α Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway

2000 • 785 citations

Regulation of MAP Kinase Signaling Modules by Scaffold Proteins in Mammals

2003 • 766 citations

MAP Kinases

2001 • 759 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

Yersinia YopJ Acetylates and Inhibits Kinase Activation by Blocking Phosphorylation

2006 • 603 citations

Regulation of Raf-1 by Direct Feedback Phosphorylation

2005 • 602 citations

Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses

2006 • 553 citations

Selective Activation of p38 Mitogen-activated Protein (MAP) Kinase Isoforms by the MAP Kinase Kinases MKK3 and MKK6

1998 • 531 citations

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

2001 • 525 citations

Mechanism of p38 MAP kinase activation in vivo

2003 • 466 citations

Docking domains and substrate-specificity determination for MAP kinases

2000 • 430 citations

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1999 • 427 citations

MAPKAP Kinase-2 Is a Cell Cycle Checkpoint Kinase that Regulates the G2/M Transition and S Phase Progression in Response to UV Irradiation

2005 • 416 citations

Inhibition of the Mitogen-Activated Protein Kinase Kinase Superfamily by a Yersinia Effector

1999 • 401 citations

Cholesterol Depletion of Caveolae Causes Hyperactivation of Extracellular Signal-related Kinase (ERK)

1998 • 375 citations

Localization of the MP1-MAPK Scaffold Complex to Endosomes Is Mediated by p14 and Required for Signal Transduction

2002 • 375 citations

Distinct Roles for JNK1 and JNK2 in Regulating JNK Activity and c-Jun-Dependent Cell Proliferation

2004 • 374 citations

Rac–MEKK3–MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock

2003 • 373 citations

Association of mitogen-activated protein kinase with the microtubule cytoskeleton.

1995 • 354 citations

Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2

1998 • 336 citations

Essential Role of MAPK Phosphatase-1 in the Negative Control of Innate Immune Responses

2006 • 330 citations

PEA-15 Mediates Cytoplasmic Sequestration of ERK MAP Kinase

2001 • 315 citations

The PHD Domain of MEKK1 Acts as an E3 Ubiquitin Ligase and Mediates Ubiquitination and Degradation of ERK1/2

2002 • 314 citations

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

2003 • 312 citations

NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling

2002 • 312 citations

Crystal Structures of MAP Kinase p38 Complexed to the Docking Sites on Its Nuclear Substrate MEF2A and Activator MKK3b

2002 • 309 citations

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

1996 • 308 citations

Sef Is a Spatial Regulator for Ras/MAP Kinase Signaling

2004 • 280 citations

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

2001 • 278 citations

Interaction of a Mitogen-Activated Protein Kinase Signaling Module with the Neuronal Protein JIP3

2000 • 278 citations

JSAP1, a Novel Jun N-Terminal Protein Kinase (JNK)-Binding Protein That Functions as a Scaffold Factor in the JNK Signaling Pathway

1999 • 272 citations

The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution

1997 • 272 citations

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125

2004 • 262 citations

Crystal Structure of p38 Mitogen-activated Protein Kinase

1996 • 252 citations

Involvement of the MKK6-p38γ Cascade in γ-Radiation-Induced Cell Cycle Arrest

2000 • 251 citations

Paxillin Serves as an ERK-Regulated Scaffold for Coordinating FAK and Rac Activation in Epithelial Morphogenesis

2004 • 227 citations

The Ste5p scaffold

2001 • 226 citations

IQGAP1 Binds Rap1 and Modulates Its Activity

2007 • 225 citations

Nuclear Export of Map Kinase (ERK) Involves a Map Kinase Kinase (Mek-Dependent) Active Transport Mechanism

2000 • 216 citations

A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappa B signalling pathways

1998 • 208 citations

B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK

2006 • 208 citations

Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity

2006 • 204 citations

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

1998 • 201 citations

The Activation State of p38 Mitogen-Activated Protein Kinase Determines the Efficiency of ATP Competition for Pyridinylimidazole Inhibitor Binding

1998 • 200 citations

Multiple Mitogen-Activated Protein Kinase Signaling Pathways Connect the Cot Oncoprotein to the c-junPromoter and to Cellular Transformation

2000 • 198 citations

IQGAP1 Binds ERK2 and Modulates Its Activity

2004 • 197 citations

Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro

1998 • 196 citations

SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis

1998 • 196 citations

Interaction of Rac Exchange Factors Tiam1 and Ras-GRF1 with a Scaffold for the p38 Mitogen-Activated Protein Kinase Cascade

2002 • 195 citations

POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis

2003 • 183 citations

EPAS1 trans-Activation during Hypoxia Requires p42/p44 MAPK

1999 • 171 citations

The MKK7 Gene Encodes a Group of c-Jun NH₂-Terminal Kinase Kinases

1999 • 169 citations

Regulation of gene expression by the small GTPase Rho through the ERK6 (p38γ) MAP kinase pathway

2001 • 167 citations

Role of the JIP4 Scaffold Protein in the Regulation of Mitogen-Activated Protein Kinase Signaling Pathways

2005 • 164 citations

Stress-induced Inhibition of ERK1 and ERK2 by Direct Interaction with p38 MAP Kinase

2001 • 163 citations

Docking Interactions Induce Exposure of Activation Loop in the MAP Kinase ERK2

2006 • 159 citations

Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein.

1995 • 155 citations

Protein phosphatase 5 in signal transduction

2001 • 151 citations

Conserved Docking Site Is Essential for Activation of Mammalian MAP Kinase Kinases by Specific MAP Kinase Kinase Kinases

2005 • 149 citations

IB1, a JIP-1-related Nuclear Protein Present in Insulin-secreting Cells

1998 • 141 citations

ERK2 enters the nucleus by a carrier-independent mechanism

2002 • 141 citations

Evidence for Existence of a Nuclear Pore Complex-mediated, Cytosol-independent Pathway of Nuclear Translocation of ERK MAP Kinase in Permeabilized Cells

2001 • 140 citations

APLIP1, a Kinesin Binding JIP-1/JNK Scaffold Protein, Influences the Axonal Transport of Both Vesicles and Mitochondria in Drosophila

2005 • 139 citations

A Regulatory Role for p38δ MAPK in Keratinocyte Differentiation

2003 • 137 citations

Identification of a Cytoplasmic-Retention Sequence in ERK2

1999 • 136 citations

Extracellular signals and scores of phosphatases: All roads lead to MAP kinase

2000 • 134 citations

Tpl2/Cot Signals Activate ERK, JNK, and NF-κB in a Cell-type and Stimulus-specific Manner

2005 • 134 citations

JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors

2002 • 133 citations

Axin Forms a Complex with MEKK1 and Activates c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase through Domains Distinct from Wnt Signaling

1999 • 128 citations

Regulation of ERK1 and ERK2 by Glucose and Peptide Hormones in Pancreatic β Cells

2003 • 127 citations

MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases

1997 • 111 citations

Mitotic Phosphorylation of Golgi Reassembly Stacking Protein 55 by Mitogen-activated Protein Kinase ERK2

2001 • 111 citations

Fibroblast Growth Factor Homologous Factors and the Islet Brain-2 Scaffold Protein Regulate Activation of a Stress-activated Protein Kinase

2002 • 104 citations

Identification of Novel Point Mutations in ERK2 That Selectively Disrupt Binding to MEK1

2002 • 98 citations

Murine p38-δ Mitogen-activated Protein Kinase, a Developmentally Regulated Protein Kinase That Is Activated by Stress and Proinflammatory Cytokines

1999 • 96 citations

Ubiquitylation of MEKK1 Inhibits Its Phosphorylation of MKK1 and MKK4 and Activation of the ERK1/2 and JNK Pathways

2003 • 93 citations

ERK1c regulates Golgi fragmentation during mitosis

2006 • 93 citations

Novel Protein Kinase C Isoforms Regulate Human Keratinocyte Differentiation by Activating a p38δ Mitogen-activated Protein Kinase Cascade That Targets CCAAT/Enhancer-binding Protein α

2002 • 91 citations

A Bipartite Mechanism for ERK2 Recognition by Its Cognate Regulators and Substrates

2003 • 91 citations

TAB-1 Modulates Intracellular Localization of p38 MAP Kinase and Downstream Signaling

2005 • 84 citations

The Death Effector Domain Protein PEA-15 Prevents Nuclear Entry of ERK2 by Inhibiting Required Interactions

2004 • 81 citations

Both Binding and Activation of p38 Mitogen-Activated Protein Kinase (MAPK) Play Essential Roles in Regulation of the Nucleocytoplasmic Distribution of MAPK-Activated Protein Kinase 5 by Cellular Stress

2002 • 81 citations

Specificity Determinants in MAPK Signaling to Transcription Factors

2002 • 80 citations

Feedback control of MKP-1 expression by p38

2006 • 80 citations

Axin Utilizes Distinct Regions for Competitive MEKK1 and MEKK4 Binding and JNK Activation

2003 • 73 citations

Identification of Stathmin as a Novel Substrate for p38 Delta

1998 • 72 citations

Cell adhesion differentially regulates the nucleocytoplasmic distribution of active MAP kinases

2002 • 64 citations

Cardiac Expression and Subcellular Localization of the p38 Mitogen-activated Protein Kinase Member, Stress-activated Protein Kinase-3 (SAPK3)

2002 • 62 citations

Phosphorylation at Thr-290 regulates Tpl2 binding to NF-κB1/p105 and Tpl2 activation and degradation by lipopolysaccharide

2005 • 61 citations

c-Jun-NH2 Kinase (JNK) Contributes to the Regulation of c-Myc Protein Stability

2004 • 57 citations

Mapping ERK2-MKP3 Binding Interfaces by Hydrogen/Deuterium Exchange Mass Spectrometry

2006 • 56 citations

BuCy RAFs drive cells into MEK addiction

2006 • 52 citations

Altered Regulation of ERK1b by MEK1 and PTP-SL and Modified Elk1 Phosphorylation by ERK1b Are Caused by Abrogation of the Regulatory C-terminal Sequence of ERKs

2001 • 47 citations

Protein Phosphatase 4 Is a Positive Regulator of Hematopoietic Progenitor Kinase 1

2004 • 46 citations

p38α Isoform Mxi2 Binds to Extracellular Signal-Regulated Kinase 1 and 2 Mitogen-Activated Protein Kinase and Regulates Its Nuclear Activity by Sustaining Its Phosphorylation Levels

2003 • 46 citations

The Nuclear Localization of ERK2 Occurs by Mechanisms Both Independent of and Dependent on Energy

2006 • 43 citations

Hypoxia Differentially Regulates the Mitogen- and Stress-Activated Protein Kinases

2002 • 41 citations

POSH, a scaffold protein for JNK signaling, binds to ALG‐2 and ALIX in Drosophila

2006 • 40 citations

Cyclic AMP Selectively Uncouples Mitogen-Activated Protein Kinase Cascades from Activating Signals

2006 • 39 citations

Molecular Cloning and Characterization of a Novel Dual Specificity Phosphatase, LMW-DSP2, That Lacks the Cdc25 Homology Domain

2001 • 38 citations

MEKK1 regulates the AP-1 dimer repertoire via control of JunB transcription and Fra-2 protein stability

2004 • 37 citations

JNK-Interacting Leucine Zipper Protein Is a Novel Scaffolding Protein in the Gα₁₃ Signaling Pathway

2005 • 31 citations

Mxi2, a splice variant of p38 stress-activated kinase, is a distal nephron protein regulated with kidney ischemia

2000 • 30 citations

Exip, a New Alternative Splicing Variant of p38α, Can Induce an Earlier Onset of Apoptosis in HeLa Cells

2002 • 29 citations

Phosphorylation of NF-κB1/p105 by oncoprotein kinase Tpl2: Implications for a novel mechanism of Tpl2 regulation

2006 • 28 citations

Distinct carboxy‐termini confer divergent characteristics to the mitogen‐activated protein kinase p38α and its splice isoform Mxi2

2000 • 26 citations

Paxillin Regulates Steroid-triggered Meiotic Resumption in Oocytes by Enhancing an All-or-None Positive Feedback Kinase Loop

2006 • 19 citations

Exip, a splicing variant of p38α, participates in interleukin‐1 receptor proximal complex and downregulates NF‐κB pathway

2004 • 19 citations