The Ste5p scaffold

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human

1999 • 2,692 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

1999 • 1,593 citations

Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action

1999 • 1,254 citations

Ultrasensitivity in the mitogen-activated protein kinase cascade.

1996 • 1,200 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

The Biochemical Basis of an All-or-None Cell Fate Switch in Xenopus Oocytes

1998 • 1,040 citations

MAP Kinase Pathways in the Yeast Saccharomyces cerevisiae

1998 • 939 citations

MAP kinase pathways

1999 • 875 citations

Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles

2000 • 867 citations

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

1998 • 653 citations

Elements of a single MAP kinase cascade in Saccharomyces cerevisiae mediate two developmental programs in the same cell type: mating and invasive growth.

1994 • 616 citations

Osmotic Activation of the HOG MAPK Pathway via Ste11p MAPKKK: Scaffold Role of Pbs2p MAPKK

1997 • 569 citations

Elements of the Yeast Pheromone Response Pathway Required for Filamentous Growth of Diploids

1993 • 505 citations

Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae

1994 • 499 citations

c-Jun Can Recruit JNK to Phosphorylate Dimerization Partners via Specific Docking Interactions

1996 • 495 citations

Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold properties

2000 • 494 citations

The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins

1999 • 454 citations

FUS3 encodes a cdc2+/CDC28-related kinase required for the transition from mitosis into conjugation

1990 • 437 citations

MAP Kinases with Distinct Inhibitory Functions Impart Signaling Specificity during Yeast Differentiation

1997 • 434 citations

The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta gamma subunits to downstream signalling components.

1992 • 427 citations

Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase

1999 • 427 citations

Regulation of G Protein–Initiated Signal Transduction in Yeast: Paradigms and Principles

2001 • 421 citations

Identification of a gene necessary for cell cycle arrest by a negative growth factor of yeast: FAR1 is an inhibitor of a G1 cyclin, CLN2

1990 • 401 citations

RING domains: master builders of molecular scaffolds?

2000 • 396 citations

Structural organization of MAP-kinase signaling modules by scaffold proteins in yeast and mammals

1998 • 395 citations

The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae

1998 • 386 citations

Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone.

1980 • 368 citations

Signal transduction: hanging on a scaffold

2000 • 341 citations

Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade.

1994 • 329 citations

Expanding roles for β-arrestins as scaffolds and adapters in GPCR signaling and trafficking

2001 • 316 citations

A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation

1998 • 311 citations

The riddle of MAP kinase signaling specificity

1998 • 297 citations

Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1.

1992 • 292 citations

Constitutive mutants of the protein kinase STE11 activate the yeast pheromone response pathway in the absence of the G protein.

1992 • 292 citations

FAR1 links the signal transduction pathway to the cell cycle machinery in yeast

1993 • 290 citations

FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1.

1993 • 274 citations

Pheromone response, mating and cell biology

2000 • 274 citations

Direct Inhibition of the Yeast Cyclin-Dependent Kinase Cdc28-Cln by Far1

1994 • 258 citations

Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity.

1993 • 256 citations

Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway

2000 • 253 citations

Functional analysis of the interaction between the small GTP binding protein Cdc42 and the Ste20 protein kinase in yeast.

1996 • 248 citations

Cell Polarity in Yeast

1999 • 246 citations

Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module.

1994 • 243 citations

The proliferation of MAP kinase signaling pathways in yeast

1995 • 243 citations

MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae.

1994 • 241 citations

Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gβγ complex underlies activation of the yeast pheromone response pathway

1998 • 241 citations

Polarization of yeast cells in spatial gradients of alpha mating factor.

1993 • 237 citations

The Role of Far1p in Linking the Heterotrimeric G Protein to Polarity Establishment Proteins During Yeast Mating

1998 • 232 citations

Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae.

1996 • 229 citations

Interaction of a G-protein β-subunit with a conserved sequence in Ste20/PAK family protein kinases

1998 • 223 citations

FUS3 represses CLN1 and CLN2 and in concert with KSS1 promotes signal transduction.

1991 • 211 citations

Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway

1995 • 209 citations

Pheromone Response in Yeast: Association of Bem1p with Proteins of the MAP Kinase Cascade and Actin

1995 • 209 citations

Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase

1997 • 207 citations

A Cdc24p-Far1p-Gβγ Protein Complex Required for Yeast Orientation during Mating

1999 • 202 citations

JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension

1998 • 201 citations

Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast.

1994 • 199 citations

MUTATIONS AFFECTING SEXUAL CONJUGATION AND RELATED PROCESSES IN SACCHAROMYCES CEREVISIAE. II. GENETIC ANALYSIS OF NONMATING MUTANTS

1974 • 196 citations

Nuclear sequestration of the exchange factor Cdc24 by Far1 regulates cell polarity during yeast mating

2000 • 195 citations

Regulation of the mating pheromone and invasive growth responses in yeast by two MAP kinase substrates

1997 • 194 citations

MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro

1993 • 190 citations

Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK

1998 • 189 citations

Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase.

1992 • 188 citations

A Conserved Docking Site in MEKs Mediates High-affinity Binding to MAP Kinases and Cooperates with a Scaffold Protein to Enhance Signal Transmission

2001 • 179 citations

Establishment of Cell Polarity in Yeast

1995 • 176 citations

Far1 and Fus3 link the mating pheromone signal transduction pathway to three G1-phase Cdc28 kinase complexes.

1993 • 174 citations

Association of the Yeast Pheromone Response G Protein βγ Subunits with the Map Kinase Scaffold Ste5p

1995 • 173 citations

Ste5 RING-H2 Domain: Role in Ste4-Promoted Oligomerization for Yeast Pheromone Signaling

1997 • 169 citations

Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae

2000 • 165 citations

Signaling in the Yeast Pheromone Response Pathway: Specific and High-Affinity Interaction of the Mitogen-Activated Protein (MAP) Kinases Kss1 and Fus3 with the Upstream MAP Kinase Kinase Ste7

1996 • 164 citations

Phosphorylation of the MEKK Ste11p by the PAK-like kinase Ste20p is required for MAP kinase signaling in vivo

2000 • 160 citations

The MAPKKK Ste11 regulates vegetative growth through a kinase cascade of shared signaling components

1999 • 159 citations

Dimerization in MAP-kinase signaling

2000 • 158 citations

Nuclear Shuttling of Yeast Scaffold Ste5 Is Required for Its Recruitment to the Plasma Membrane and Activation of the Mating MAPK Cascade

1999 • 156 citations

SAM: A novel motif in yeast sterile anddrosophilapolyhomeotic proteins

1995 • 148 citations

FAR1 is required for oriented polarization of yeast cells in response to mating pheromones.

1995 • 144 citations

Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae.

1997 • 143 citations

Constitutive mutants in the yeast pheromone response: Ordered function of the gene products

1989 • 143 citations

Requirement of STE50 for Osmostress-Induced Activation of the STE11 Mitogen-Activated Protein Kinase Kinase Kinase in the High-Osmolarity Glycerol Response Pathway

1998 • 140 citations

A GTP-exchange factor required for cell orientation

1998 • 136 citations

The MAP kinase Fus3 associates with and phosphorylates the upstream signaling component Ste5.

1994 • 129 citations

How regulated protein translocation can produce switch-like responses

1998 • 124 citations

The Evolution of the MAP Kinase Pathways: Coduplication of Interacting Proteins Leads to New Signaling Cascades

1999 • 122 citations

Nucleocytoplasmic Shuttling of the Cdc42p Exchange Factor Cdc24p

2000 • 115 citations

Comparison of dose-response curves for alpha factor-induced cell division arrest, agglutination, and projection formation of yeast cells. Implication for the mechanism of alpha factor action.

1983 • 111 citations

Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients.

1995 • 110 citations

Functional binding between Gβ and the LIM domain of Ste5 is required to activate the MEKK Ste11

1998 • 110 citations

The guanine-nucleotide-exchange factor Cdc24p is targeted to the nucleus and polarized growth sites

1999 • 106 citations

The Osmoregulatory Pathway Represses Mating Pathway Activity in Saccharomyces cerevisiae: Isolation of a FUS3 Mutant That Is Insensitive to the Repression Mechanism

1996 • 99 citations

The SH3-Domain Protein Bem1 Coordinates Mitogen-Activated Protein Kinase Cascade Activation with Cell Cycle Control in Saccharomyces cerevisiae

1996 • 97 citations

Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p

1999 • 95 citations

G Proteins Mediate Changes in Cell Shape by Stabilizing the Axis of Polarity

2000 • 94 citations

Ste5: a meeting place for MAP kinases and their associates

1995 • 93 citations

Mutational Analysis of STE5 in the Yeast Saccharomyces cerevisiae: Application of a Differential Interaction Trap Assay for Examining Protein-Protein Interactions

1997 • 93 citations

Responding to attraction: chemotaxis and chemotropism in Dictyostelium and yeast

1999 • 93 citations

Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction

1996 • 91 citations

A role for the yeast actin cytoskeleton in pheromone receptor clustering and signalling

1998 • 88 citations

Phosphorylation and localization of Kss1, a MAP kinase of the Saccharomyces cerevisiae pheromone response pathway.

1995 • 86 citations

Activation of the Saccharomyces cerevisiae Filamentation/Invasion Pathway by Osmotic Stress in High-Osmolarity Glycogen Pathway Mutants

1999 • 80 citations

Role of Cdc42p in Pheromone-Stimulated Signal Transduction in Saccharomyces cerevisiae

2000 • 78 citations

Functional Characterization of the Interaction of Ste50p with Ste11p MAPKKK inSaccharomyces cerevisiae

1999 • 78 citations

Mating in Saccharomyces cerevisiae: The Role of the Pheromone Signal Transduction Pathway in the Chemotropic Response to Pheromone

1997 • 76 citations

Yeast MEK-Dependent Signal Transduction: Response Thresholds and Parameters Affecting Fidelity

1995 • 70 citations

Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway.

1994 • 69 citations

ACTIN: General Principles from Studies in Yeast

1996 • 62 citations

Mutational Analysis Suggests That Activation of the Yeast Pheromone Response Mitogen-activated Protein Kinase Pathway Involves Conformational Changes in the Ste5 Scaffold Protein

2000 • 61 citations

Cloning of Saccharomyces cerevisiae STE5 as a suppressor of a Ste20 protein kinase mutant: structural and functional similarity of Ste5 to Farl

1993 • 59 citations

Relative Dependence of Different Outputs of the Saccharomyces cerevisiae Pheromone Response Pathway on the MAP Kinase Fus3p

1999 • 58 citations

Genetic Relationships Between the G Protein βγ Complex, Ste5p, Ste20p and Cdc42p: Investigation of Effector Roles in the Yeast Pheromone Response Pathway

1996 • 57 citations

Ste50p sustains mating pheromone‐induced signal transduction in the yeast Saccharomyces cerevisiae

1996 • 56 citations

Ste50p is involved in regulating filamentous growth in the yeast Saccharomyces cerevisiae and associates with Ste11p

1998 • 53 citations

Characterization of Fus3 Localization: Active Fus3 Localizes in Complexes of Varying Size and Specific Activity

1999 • 42 citations

Function of the Ste Signal Transduction Pathway for Mating Pheromones Sustains MATα1 Transcription in Saccharomyces cerevisiae

1993 • 39 citations

Programming of Cell Polarity in Budding Yeast by Endogenous and Exogenous Signals

1995 • 39 citations

Mapping of a Yeast G Protein βγ Signaling Interaction

1998 • 32 citations

Human cyclins A and B1 are differentially located in the cell and undergo cell cycle-dependent nuclear transport

1992 • 31 citations

Mutations in the YRB1 Gene Encoding Yeast Ran-Binding-Protein-1 That Impair Nucleocytoplasmic Transport and Suppress Yeast Mating Defects

2001 • 30 citations

The ins and outs of cell-polarity decisions

2000 • 25 citations

Function of the ste signal transduction pathway for mating pheromones sustains MAT alpha 1 transcription in Saccharomyces cerevisiae.

1993 • 21 citations

Concentration-dependent positive and negative regulation of a MAP kinase by a MAP kinase kinase

1999 • 19 citations

far4, far5, and far6 define three genes required for efficient activation of MAPKs Fus3 and Kss1 and accumulation of glycogen

2001 • 15 citations