Hypoxia Differentially Regulates the Mitogen- and Stress-Activated Protein Kinases

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

1994 • 3,219 citations

A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells

1994 • 2,659 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

1994 • 1,684 citations

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

1996 • 1,519 citations

Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation

1996 • 1,099 citations

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

1995 • 1,087 citations

Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)

1996 • 744 citations

Characterization of the Structure and Function of the Fourth Member of p38 Group Mitogen-activated Protein Kinases, p38δ

1997 • 482 citations

The Primary Structure of p38γ: A New Member of p38 Group of MAP Kinases

1996 • 393 citations

Tissue-specific Pattern of Stress Kinase Activation in Ischemic/Reperfused Heart and Kidney

1997 • 374 citations

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

1997 • 363 citations

Molecular Cloning and Characterization of a Novel p38 Mitogen-activated Protein Kinase

1997 • 332 citations

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation.

1996 • 331 citations

The stress-activated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion

1994 • 266 citations

Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells.

1994 • 264 citations

Hypoxia-induced Protein Binding to O2-responsive Sequences on the Tyrosine Hydroxylase Gene

1995 • 199 citations

Selective Activation of p38α and p38γ by Hypoxia

1999 • 179 citations

p38-2, a Novel Mitogen-activated Protein Kinase with Distinct Properties

1997 • 176 citations

SAP kinase‐3, a new member of the family of mammalian stress‐activated protein kinases

1996 • 159 citations

Membrane depolarization in PC-12 cells during hypoxia is regulated by an O2-sensitive K+ current

1996 • 139 citations

Selective inhibition of a slow‐inactivating voltage‐dependent K⁺ channel in rat PC 12 cells by hypoxia

1997 • 135 citations

Mitogen-activated Protein Kinase Phosphatase-1 (MKP-1) Expression Is Induced by Low Oxygen Conditions Found in Solid Tumor Microenvironments

1999 • 130 citations

Hypoxia Induces Phosphorylation of the Cyclic AMP Response Element-binding Protein by a Novel Signaling Mechanism

1998 • 129 citations

Calcium Influx Activates Extracellular-regulated Kinase/Mitogen-activated Protein Kinase Pathway through a Calmodulin-sensitive Mechanism in PC12 Cells

1999 • 95 citations

The stress activated protein kinase pathway.

1996 • 90 citations

Release of dopamine and norepinephrine by hypoxia from PC-12 cells

1998 • 86 citations

Hypoxia Evokes Catecholamine Secretion from Rat Pheochromocytoma PC-12 Cells

1998 • 59 citations

Regulation of tyrosine hydroxylase gene expression during hypoxia: Role of Ca2+ and PKC

1997 • 58 citations

Cell selective induction and transcriptional activation of immediate early genes by hypoxia

1995 • 51 citations

The Use of PC12 Cells for the Study of the Mechanism of Action of Neurotrophic Factors: Signal Transduction and Programmed Cell Death

1995 • 17 citations