Going APE over ref-1

VMD: Visual molecular dynamics

1996 • 54,630 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

1996 • 2,304 citations

Regulation of Mammalian O₂Homeostasis by Hypoxia-Inducible Factor 1

1999 • 1,882 citations

Redox Regulation of Fos and Jun DNA-Binding Activity in Vitro

1990 • 1,592 citations

Two interdependent basic domains in nucleoplasmin nuclear targeting sequence: Identification of a class of bipartite nuclear targeting sequence

1991 • 1,501 citations

Rate of depurination of native deoxyribonucleic acid

1972 • 1,488 citations

REPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and Biology

1994 • 1,435 citations

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

1996 • 1,172 citations

Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme.

1992 • 920 citations

MUTAGENESIS BY APURINIC/APYRIMIDINIC SITES

1986 • 884 citations

AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1

1997 • 836 citations

DNA REPAIR ENZYMES

1988 • 822 citations

Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1)

1997 • 779 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination

2000 • 700 citations

Excision of Deoxyribose Phosphate Residues by DNA Polymerase β During DNA Repair

1995 • 670 citations

ATF3 and stress responses.

1999 • 621 citations

Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300

1999 • 583 citations

A nucleotide-flipping mechanism from the structure of human uracil–DNA glycosylase bound to DNA

1996 • 576 citations

DNA binding site of the growth factor-inducible protein Zif268.

1989 • 563 citations

Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.

1991 • 526 citations

Two Pathways for Base Excision Repair in Mammalian Cells

1996 • 520 citations

Is CREB a key to neuronal survival?

2000 • 516 citations

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

1996 • 499 citations

p53 in growth control and neoplasia

1996 • 488 citations

Identification of redox/repair protein Ref-1 as a potent activator of p53.

1997 • 479 citations

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA

1998 • 474 citations

Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation

1999 • 433 citations

Activation of apurinic/apyrimidinic endonuclease in human cells by reactive oxygen species and its correlation with their adaptive response to genotoxicity of free radicals

1998 • 414 citations

Structure and function of the multifunctional DNA-repair enzyme exonuclease III

1995 • 382 citations

The enzymology of apurinic/apyrimidinic endonucleases

1990 • 378 citations

Redox-Regulated Recruitment of the Transcriptional Coactivators CREB-Binding Protein and SRC-1 to Hypoxia-Inducible Factor 1α

2000 • 371 citations

Mammalian Abasic Site Base Excision Repair

1998 • 369 citations

The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains.

1994 • 351 citations

Interaction of human apurinic endonuclease and DNA polymerase β in the base excision repair pathway

1997 • 344 citations

Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues.

1999 • 343 citations

Enzymatic Processing of Radiation-Induced Free Radical Damage in DNA

1998 • 330 citations

Pax genes and their roles in cell differentiation and development

1996 • 325 citations

Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression.

1995 • 324 citations

DNA Polymerase β Conducts the Gap-filling Step in Uracil-initiated Base Excision Repair in a Bovine Testis Nuclear Extract

1995 • 317 citations

The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites

1997 • 316 citations

Infidelity of DNA synthesis associated with bypass of apurinic sites.

1983 • 301 citations

Isolation of cDNA clones encoding a human apurini/apyrimidinic endonuclease that corects DNA repair and mutagenisis defects inE.coli xth(exonuclease III) mutants

1991 • 294 citations

Incision Activity of Human Apurinic Endonuclease (Ape) at Abasic Site Analogs in DNA

1995 • 275 citations

Mammalian base excision repair and DNA polymerase beta

1998 • 275 citations

Highly sensitive apurinic/apyrimidinic site assay can detect spontaneous and chemically induced depurination under physiological conditions.

1998 • 271 citations

Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding.

1993 • 270 citations

Two distinct human DNA diesterases that hydrolyze 3′-blocking deoxyribose fragments from oxidized DNA

1991 • 265 citations

Ap endonucleases and dna glycosylases that recognize oxidative dna damage

1988 • 254 citations

Activation of AP-1 and of a nuclear redox factor, Ref-1, in the response of HT29 colon cancer cells to hypoxia.

1994 • 241 citations

Ref-1 regulates the transactivation and pro-apoptotic functions of p53 in vivo

1999 • 241 citations

A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress

1994 • 221 citations

Structure and function of apurinic/apyrimidinic endonucleases

1995 • 205 citations

Implication of Mammalian Ribosomal Protein S3 in the Processing of DNA Damage

1995 • 193 citations

Elevated and altered expression of the multifunctional DNA base excision repair and redox enzyme Ape1/ref-1 in prostate cancer.

2001 • 187 citations

A Redox Mechanism Controls Differential DNA Binding Activities of Hypoxia-inducible Factor (HIF) 1α and the HIF-like Factor

2000 • 177 citations

Thioredoxin: a redox-regulating cellular cofactor for glucocorticoid hormone action. Cross talk between endocrine control of stress response and cellular antioxidant defense system.

1996 • 170 citations

Evidence for an Imino Intermediate in the DNA Polymerase β Deoxyribose Phosphate Excision Reaction

1996 • 165 citations

Regulation of Repair of Alkylation Damage in Mammalian Genomes

1993 • 164 citations

Characterization of the DNA-Binding Properties of the Early Growth Response-1 (Egr-1) Transcription Factor: Evidence for Modulation by a Redox Mechanism

1993 • 163 citations

Substrate Binding by Human Apurinic/Apyrimidinic Endonuclease Indicates a Briggs-Haldane Mechanism

1997 • 154 citations

Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-κB in vitro

1994 • 153 citations

Repair of DNA damage in mitochondria

1999 • 150 citations

The solution structure of human thioredoxin complexed with its target from Ref-1 reveals peptide chain reversal

1996 • 148 citations

DNA Damages Processed by Base Excision Repair: Biological Consequences

1994 • 147 citations

Redox Regulation of the DNA Binding Activity in Transcription Factor PEBP2

1997 • 143 citations

Apurinic endonuclease (Ref-1) is induced in mammalian cells by oxidative stress and involved in clastogenic adaptation.

1998 • 139 citations

Complexities of DNA Base Excision Repair in Mammalian Cells

1997 • 136 citations

A redox factor protein, ref1, is involved in negative gene regulation by extracellular calcium.

1994 • 134 citations

Alterations in the expression of the DNA repair/redox enzyme APE/ref-1 in epithelial ovarian cancers.

2000 • 132 citations

Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1

1995 • 130 citations

The role of Mg2+ and specific amino acid residues in the catalytic reaction of the major human abasic endonuclease: new insights from EDTA-resistant incision of acyclic abasic site analogs and site-directed mutagenesis

1999 • 125 citations

Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease

1994 • 121 citations

Site-directed mutagenesis of the human DNA repair enzyme HAP1: identification of residues important for AP endonuclease and RNase H activity

1995 • 119 citations

Escape from redox regulation enhances the transforming activity of Fos.

1993 • 119 citations

Envisioning the molecular choreography of DNA base excision repair

1999 • 117 citations

HIF-1α and p53 Promote Hypoxia-Induced Delayed Neuronal Death in Models of CNS Ischemia

1999 • 114 citations

Dynamics of the Interaction of Human Apurinic Endonuclease (Ape1) with Its Substrate and Product

1998 • 112 citations

An environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation

2000 • 109 citations

cDNA and deduced amino acid sequence of a mouse DNA repair enzyme (APEX nuclease) with significant homology to Escherichia coli exonuclease III.

1991 • 109 citations

Redox Potential Controls the Structure and DNA Binding Activity of the Paired Domain

1998 • 107 citations

Elements in abasic site recognition by the major human and Escherichia coli apurinic/apyrimidinic endonucleases

1998 • 105 citations

Phosphorylation of the DNA repair protein APE/REF-1 by CKII affects redox regulation of AP-1

1999 • 102 citations

Recognition of oxidized abasic sites by repair endonucleases

1994 • 99 citations

Subunit Association and DNA Binding Activity of the Heterotrimeric Transcription Factor NF-Y Is Regulated by Cellular Redox

1996 • 97 citations

Rapid Dissociation of Human Apurinic Endonuclease (Ape1) from Incised DNA Induced by Magnesium

1998 • 97 citations

Deletion analysis of human AP-endonuclease: minimum sequence required for the endonuclease activity

1998 • 97 citations

The apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme is elevated in premalignant and malignant cervical cancer.

1998 • 94 citations

Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers

1998 • 93 citations

Evidence of reduced DNA repair in amyotrophic lateral sclerosis brain tissue

1997 • 93 citations

Differential expression of the apurinic/apyrimidinic endonuclease (APE/ref-1) multifunctional DNA base excision repair gene during fetal development and in adult rat brain and testis

1996 • 92 citations

Ref-1 Controls Pax-8 DNA-Binding Activity

1998 • 89 citations

The DNA repair activity of human redox/repair protein APE/Ref-1 is inactivated by phosphorylation.

1997 • 88 citations

Mutant AP endonuclease in patients with amyotrophic lateral sclerosis

1998 • 88 citations

The Arabidopsis thaliana apurinic endonuclease Arp reduces human transcription factors Fos and Jun.

1994 • 88 citations

Differential cellular and subcellular expression of the human multifunctional apurinic/apyrimidinic endonuclease (APE/ref-1) DNA repair enzyme.

1995 • 87 citations

Early Decrease of Apurinic/Apyrimidinic Endonuclease Expression after Transient Focal Cerebral Ischemia in Mice

1999 • 83 citations

Drosophila ribosomal protein PO contains apurinic/apyrimidinic endonuclease activity

1996 • 83 citations

Reduction of Apurinic/Apyrimidinic Endonuclease Expression After Transient Global Cerebral Ischemia in Rats

1999 • 83 citations

Expression and subcellular localization of human AP endonuclease 1 (HAP1/Ref‐1) protein: a basis for its role in human disease

1998 • 83 citations

Transactivation of an inducible anti-oxidative stress protein, human thioredoxin by HTLV-I Tax

1996 • 82 citations

Asbestos increases mammalian AP-endonuclease gene expression, protein levels, and enzyme activity in mesothelial cells.

1998 • 82 citations

Transcriptional Activation of Apurinic/Apyrimidinic Endonuclease (Ape, Ref-1) by Oxidative Stress Requires CREB

1999 • 78 citations

Negative Regulation of the Major Human AP-Endonuclease, a Multifunctional Protein^,

1996 • 74 citations

The avian cellular homolog of the oncogene jun.

1988 • 74 citations

A holistic approach to protein structure alignment

1989 • 72 citations

Immunoelectron microscopic studies on the location of ribosomal proteins on the surface of the 40S ribosomal subunit from rat liver.

1990 • 71 citations

Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons

1997 • 70 citations

The Interaction between Ku Antigen and REF1 Protein Mediates Negative Gene Regulation by Extracellular Calcium

1996 • 70 citations

Human AP endonuclease 1 (HAP1) protein expression in breast cancer correlates with lymph node status and angiogenesis

1998 • 69 citations

Down-regulation of apurinic/apyrimidinic endonuclease expression is associated with the induction of apoptosis in differentiating myeloid leukemia cells.

1997 • 69 citations

Redox Factor-1 (Ref-1) Mediates the Activation of AP-1 in HeLa and NIH 3T3 Cells in Response to Heat Shock

1999 • 64 citations

The Drosophila Ribosomal Protein S3 Contains a DNA Deoxyribophosphodiesterase (dRpase) Activity

1997 • 64 citations

Immunohistochemical localization of redox factor-1 (Ref-1) in Alzheimerʼs hippocampus

1998 • 63 citations

TSH controls Ref-1 nuclear translocation in thyroid cells

2000 • 62 citations

APE/Ref-1 responses to oxidative stress in aged rats

1998 • 62 citations

Overexpression of human DNA repair protein N-methylpurine-DNA glycosylase results in the increased removal of N-methylpurines in DNA without a concomitant increase in resistance to alkylating agents in Chinese hamster ovary cells

1992 • 61 citations

Structure of the human DNA repair geneHAP1and its localisation to chromosome 14q 11.2–12

1992 • 58 citations

Human apurinic endonuclease 1 expression in a colorectal adenoma-carcinoma sequence.

1997 • 55 citations

Developmental expression of APEX nuclease, a multifunctional DNA repair enzyme, in mouse brains

1995 • 52 citations

Intragenic suppression of an active site mutation in the human apurinic/apyrimidinic endonuclease 1 1Edited by P. E. Wright

1999 • 51 citations

Partial Characterization of the Human CYP1A1 Negatively Acting Transcription Factor and Mutational Analysis of Its Cognate DNA Recognition Sequence

1995 • 50 citations

Expression of nuclear redox factor ref-1 in the rat hippocampus following global ischemia induced by cardiac arrest

1997 • 49 citations

Nuclear localization of human AP endonuclease 1 (HAP1/Ref-1) associates with prognosis in early operable non-small cell lung cancer (NSCLC)

1999 • 48 citations

Early decrease in apurinic/apyrimidinic endonuclease is followed by DNA fragmentation after cold injury-induced brain trauma in mice

1999 • 48 citations

Biological Responses of Human Apurinic Endonuclease to Radiation‐Induced DNA Damage

1994 • 46 citations

Expression of yeast but not human apurinic/apyrimidinic endonuclease renders Chinese hamster cells more resistant to DNA damaging agents

1997 • 45 citations

Single-Turnover Analysis of Mutant Human Apurinic/Apyrimidinic Endonuclease^,

1999 • 44 citations

Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1

1996 • 44 citations

APE/Ref-1 responses to ischemia in rat brain

1998 • 39 citations

Overexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugs

1999 • 38 citations

Increase in Ref-1 mRNA and Protein by Thyrotropin in Rat Thyroid FRTL-5 Cells

1997 • 38 citations

Creation of a Fully Functional Human Chimeric DNA Repair Protein

1998 • 37 citations

Trans-complementation by human apurinic endonuclease (Ape) of hypersensitivity to DNa damage and spontaneous mutator phenotype in apn 1^-yeast

1995 • 37 citations

Characterization of the Promoter Region of the Human Apurinic Endonuclease Gene (APE)

1995 • 34 citations

Expression of a multifunctional DNA repair enzyme gene, apurinic/apyrimidinic endonuclease (APE; Ref-1) in the suprachiasmatic, supraoptic and paraventricular nuclei

1994 • 34 citations

Histology-Specific Expression of a DNA Repair Protein in Pediatric Rhabdomyosarcomas

2001 • 33 citations

Expression levels of the DNA repair enzyme HAP1 do not correlate with the radiosensitivities of human or HAP1-transfected rat cell lines

1999 • 32 citations

Human apurinic endonuclease gene (APE): structure and genomic mapping (chromosome 1 4q11.2 - 12)

1992 • 31 citations

Induction of double-strand breaks by S1 nuclease, mung bean nuclease and nuclease P1 in DNA containing abasic sites and nicks

1995 • 30 citations

Transcriptional activation by the Myb proteins requires a specific local promoter structure

1999 • 29 citations

Relationship between expression of a major apurinic/apyrimidinic endonuclease (APEX nuclease) and susceptibility to genotoxic agents in human glioma cell lines

1995 • 26 citations

Domain Mapping of Human Apurinic/Apyrimidinic Endonuclease

1998 • 25 citations

Structure, promoter analysis and chromosomal assignment of the human APEX gene

1994 • 24 citations

Nucleotide excision repair of DNA in eukaryotes: comparisons between human cells and yeast.

1985 • 21 citations

SHORT COMMUNICATION: Regulated expression of APE apurinic endonuclease mRNA during wound healing in porcine epidermis

1996 • 20 citations

Inductions of immediate early genes (IEGs) and ref‐1 by human chorionic gonadotropin in murine Leydig cell line (MA‐10)

1998 • 19 citations

Cloning of the multifunctional<u>r</u>at<u>ap</u>urinic/apyrimidinic<u>e</u>ndo<u>n</u>uclease (rAPEN)/redox factor from an immature T cell line

1994 • 18 citations

The human gene fro apurinic/apyrimidinic endonuclease (HAP1): sequence and localization to chromosome 14 band q12

1992 • 18 citations

Comparison of the promoters of the mouse (APEX) and human (APE) apurinic endonuclease genes

1997 • 18 citations

Analysis of repair of abasic sites in early onset breast cancer patients

2000 • 16 citations

cDNA cloning of rat major AP endonuclease (APEX nuclease) and analyses of its mRNA expression in rat tissues.

1996 • 15 citations

Reduction of Radiation Cytotoxicity by Human Apurinic Endonuclease in a Radiation-Sensitive Escherichia coli Mutant

1993 • 14 citations

Post-Translational Regulation of AP-1 Transcription Factor DNA-Binding Activity in the Rat Conceptus

1999 • 13 citations

cDNA cloning of rat major AP endonuclease (APEX nuclease)and analyses of its mRNA expression in Rat Tissues

1996 • 9 citations

Molecular cloning, sequence and structure analysis of hamster apurinic/apyrimidinic endonuclease (chAPE1) gene

1999 • 6 citations

EXPRESSION OF THE HUMAN APURINIC ENDONUCLEASE GENE (APE) IN NORMAL AND MALIGNANT-TISSUES

1995 • 3 citations