The role of Mg2+ and specific amino acid residues in the catalytic reaction of the major human abasic endonuclease: new insights from EDTA-resistant incision of acyclic abasic site analogs and site-directed mutagenesis

Instability and decay of the primary structure of DNA

1993 • 5,370 citations

REPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and Biology

1994 • 1,435 citations

Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

1991 • 1,059 citations

MUTAGENESIS BY APURINIC/APYRIMIDINIC SITES

1986 • 884 citations

DNA glycosylases in the base excision repair of DNA

1997 • 840 citations

Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.

1991 • 526 citations

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

1996 • 499 citations

Oligodeoxynucleotides containing synthetic abasic sites. Model substrates for DNA polymerases and apurinic/apyrimidinic endonucleases.

1987 • 399 citations

Structure and function of the multifunctional DNA-repair enzyme exonuclease III

1995 • 382 citations

Structure of DNase I at 2.0 Å resolution suggests a mechanism for binding to and cutting DNA

1986 • 327 citations

The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites

1997 • 316 citations

Isolation of cDNA clones encoding a human apurini/apyrimidinic endonuclease that corects DNA repair and mutagenisis defects inE.coli xth(exonuclease III) mutants

1991 • 294 citations

Incision Activity of Human Apurinic Endonuclease (Ape) at Abasic Site Analogs in DNA

1995 • 275 citations

Mammalian base excision repair and DNA polymerase beta

1998 • 275 citations

Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis.

1996 • 271 citations

X-ray structure of the DNase I-d(GGTATACC)2 complex at 2·3Å resolution

1992 • 248 citations

Purification and characterization of an apurinic/apyrimidinic endonuclease from HeLa cells.

1981 • 161 citations

Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1

1995 • 130 citations

Elements in abasic site recognition by the major human and Escherichia coli apurinic/apyrimidinic endonucleases

1998 • 105 citations

Rapid Dissociation of Human Apurinic Endonuclease (Ape1) from Incised DNA Induced by Magnesium

1998 • 97 citations

Abasic Site Binding by the Human Apurinic Endonuclease, Ape, and Determination of the DNA Contact Sites

1997 • 92 citations

Site-directed Mutagenesis of the Catalytic Residues of Bovine Pancreatic Deoxyribonuclease I

1996 • 78 citations

Probing the Function of Asp128 in the Low Molecular Weight Protein-Tyrosine Phosphatase-Catalyzed Reaction. A Pre-Steady-State and Steady-State Kinetic Investigation

1996 • 70 citations

Mechanism of Phosphatidylinositol-Specific Phospholipase C: A Unified View of the Mechanism of Catalysis^,

1998 • 70 citations

NMR studies of abasic sites in DNA duplexes: deoxyadenosine stacks into the helix opposite acyclic lesions

1989 • 59 citations

Structure of the human DNA repair geneHAP1and its localisation to chromosome 14q 11.2–12

1992 • 58 citations

Intragenic suppression of an active site mutation in the human apurinic/apyrimidinic endonuclease 1 1Edited by P. E. Wright

1999 • 51 citations

Inert Chromium and Cobalt Complexes as Probes of Magnesium‐Dependent Enzymes

1997 • 29 citations

Evidence for a Common Active Site for Cleavage of an AP Site and the Benzene-Derived Exocyclic Adduct, 3,N⁴-Benzetheno-dC, in the Major Human AP Endonuclease

1997 • 29 citations

1 Mechanistic Principles of Enzyme-catalyzed Cleavage of Phosphodiester Bonds

1993 • 29 citations

Regulation of eukaryotic abasic endonucleases and their role in genetic stability.

1997 • 24 citations

Conversion of bovine pancreatic DNase I to a repair endonuclease with a high selectivity for abasic sites

1998 • 18 citations