Overexpression of the human HAP1 protein sensitizes cells to the lethal effect of bioreductive drugs

The mammalian ultraviolet response is triggered by activation of src tyrosine kinases

1992 • 874 citations

Identification and characterization of Ref-1, a nuclear protein that facilitates AP-1 DNA-binding activity.

1992 • 702 citations

Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes.

1991 • 526 citations

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

1996 • 499 citations

Use of the polymerase chain reaction in the quantitation of MDR-1 gene expression

1990 • 427 citations

The crystal structure of the human DNA repair endonuclease HAP1 suggests the recognition of extra-helical deoxyribose at DNA abasic sites

1997 • 316 citations

NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.

1992 • 313 citations

Role of Cysteine Residues in Regulation of p53 Function

1995 • 301 citations

Isolation of cDNA clones encoding a human apurini/apyrimidinic endonuclease that corects DNA repair and mutagenisis defects inE.coli xth(exonuclease III) mutants

1991 • 294 citations

Identification of residues in the human DNA repair enzyme HAP1 (Ref-1) that are essential for redox regulation of Jun DNA binding.

1993 • 270 citations

A role for the human DNA repair enzyme HAP1 in cellular protection against DNA damaging agents and hypoxic stress

1994 • 221 citations

Structure and function of apurinic/apyrimidinic endonucleases

1995 • 205 citations

Directed mutagenesis : a practical approach

1991 • 163 citations

Coding properties of poly(deoxycytidylic acid) templates containing uracil or apyrimidinic sites: in vitro modulation of mutagenesis by deoxyribonucleic acid repair enzymes

1982 • 142 citations

Repair of intrinsic DNA lesions

1990 • 126 citations

Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme, APEX nuclease

1994 • 121 citations

Reductive activation of mitomycin C by NADH:cytochrome b5 reductase.

1993 • 116 citations

Removal of 3′-phosphoglycolate from DNA strand-break damage in an oligonucleotide substrate by recombinant human apurinic/apyrimidinic endonuclease 1

1994 • 95 citations

Properties of the Endonuclease for Depurinated DNA from Escherichia coli

1972 • 85 citations

Differential toxicity of mitomycin C and porfiromycin to aerobic and hypoxic Chinese hamster ovary cells overexpressing human NADPH:cytochrome c (P-450) reductase.

1996 • 75 citations

Relationship between DT-diaphorase-mediated metabolism of a series of aziridinylbenzoquinones and DNA damage and cytotoxicity.

1992 • 75 citations

Mechanisms of hypoxic and aerobic cytotoxicity of mitomycin C in Chinese hamster V79 cells.

1991 • 70 citations

Immunocytochemical localization of the base excision repair enzyme uracil DNA glycosylase in quiescent and proliferating normal human cells.

1989 • 49 citations

Detection of mitomycin C-DNA adducts in vivo by 32P-postlabeling: time course for formation and removal of adducts and biochemical modulation.

1998 • 48 citations

Asparagine 212 is essential for abasic site recognition by the human DNA repair endonuclease HAP1

1996 • 44 citations

Effect of site specifically located mitomycin C-DNA monoadducts on in vitro DNA synthesis by DNA polymerases

1993 • 40 citations

Trans-complementation by human apurinic endonuclease (Ape) of hypersensitivity to DNa damage and spontaneous mutator phenotype in apn 1^-yeast

1995 • 37 citations

Expression of theE.colifpg gene in mammalian cells reduces the mutagenicity of γ-rays

1994 • 30 citations

Effects of Glutathione on Alkylation and Crosslinking of DNA by Mitomycin C. Isolation of a Ternary Glutathione-Mitomycin-DNA Adduct

1994 • 27 citations

Increased resistance of the Chinese hamster mutant irsl cells to monofunctional alkylating agents by transfection of the E. coli or mammalian N3-methyladenine-DNA-glycosylase genes

1993 • 22 citations

Reduction of Radiation Cytotoxicity by Human Apurinic Endonuclease in a Radiation-Sensitive Escherichia coli Mutant

1993 • 14 citations

Site-directed in vitro mutagenesis using uracil-containing DNA and phagemid vectors

1991 • 13 citations

Effect of pH on DNA alkylation by enzyme-activated mitomycin C and porfiromycin.

1993 • 10 citations