Cyclooxygenase‐independent actions of cyclooxygenase inhibitors

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs

1971 • 8,596 citations

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

1995 • 3,603 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

de la Chapelle, A.

1997 • 3,184 citations

Activators and Target Genes of Rel/NF-кB Transcription Factors

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NF-κB: Ten Years After

1996 • 3,008 citations

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

NF-κB Antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to Suppress Caspase-8 Activation

1998 • 2,698 citations

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

2000 • 2,505 citations

Cyclooxygenase in biology and disease

1998 • 2,483 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

Cyclooxygenase Regulates Angiogenesis Induced by Colon Cancer Cells

1998 • 2,282 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Mammalian G1 cyclins

1993 • 1,990 citations

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

1996 • 1,962 citations

The PPARs: From Orphan Receptors to Drug Discovery

2000 • 1,792 citations

Inhibition of NF-κB by Sodium Salicylate and Aspirin

1994 • 1,743 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis

1999 • 1,488 citations

Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

1994 • 1,410 citations

Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.

2000 • 1,310 citations

Inducible cyclooxygenase may have anti-inflammatory properties

1999 • 1,246 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Association of the APC Tumor Suppressor Protein with Catenins

1993 • 1,202 citations

Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells.

1998 • 1,130 citations

Aberrant rel/nfkb genes and activity in human cancer

1999 • 1,127 citations

Risk of Alzheimer's disease and duration of NSAID use

1997 • 1,113 citations

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs

1997 • 1,106 citations

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

1993 • 1,096 citations

PPARδ Is an APC-Regulated Target of Nonsteroidal Anti-Inflammatory Drugs

1999 • 1,091 citations

D-type cyclin-dependent kinase activity in mammalian cells.

1994 • 1,073 citations

MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-β superfamily

1997 • 1,047 citations

Formation and Activation of a Cyclin E-cdk2 Complex During the G ₁ Phase of the Human Cell Cycle

1992 • 1,046 citations

The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation

1996 • 1,036 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

Clinical trial of indomethacin in Alzheimer's disease

1993 • 996 citations

Acceleration of the G₁/S Phase Transition by Expression of Cyclins Dl and E with an Inducible System

1994 • 986 citations

Differentiation and reversal of malignant changes in colon cancer through PPARγ

1998 • 984 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Activation of Proliferator-activated Receptors α and γ Induces Apoptosis of Human Monocyte-derived Macrophages

1998 • 914 citations

Association of human cyclin E with a periodic G1-S phase protein kinase

1992 • 900 citations

Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

1998 • 850 citations

Terminal Differentiation of Human Breast Cancer through PPARγ

1998 • 844 citations

Interleukin-4-dependent production of PPAR-γ ligands in macrophages by 12/15-lipoxygenase

1999 • 835 citations

Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing

1999 • 830 citations

Characterization of Mechanisms Involved in Transrepression of NF-κB by Activated Glucocorticoid Receptors

1995 • 815 citations

Identification of G1 kinase activity for cdk6, a novel cyclin D partner.

1994 • 798 citations

Cyclin-Dependent Regulation of G ₁ in Mammalian Fibroblasts

1993 • 767 citations

Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation

1996 • 760 citations

Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids

1995 • 700 citations

Dendritic Cell Survival and Maturation Are Regulated by Different Signaling Pathways

1998 • 685 citations

The Cyclooxygenase-2 Inhibitor Celecoxib Induces Apoptosis by Blocking Akt Activation in Human Prostate Cancer Cells Independently of Bcl-2

2000 • 670 citations

Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene

1988 • 661 citations

Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system.

1994 • 659 citations

Cytochrome c Release and Apoptosis Induced by Mitochondrial Targeting of Nuclear Orphan Receptor TR3

2000 • 651 citations

Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

1995 • 632 citations

Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway

1996 • 613 citations

Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E

1997 • 601 citations

Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.

1998 • 599 citations

Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta

1999 • 589 citations

Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.

1982 • 588 citations

Activation of NF-?B protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

1997 • 572 citations

Identification of the DNA Binding Site for NGFI-B by Genetic Selection in Yeast

1991 • 566 citations

Requirement of NF-κB Activation to Suppress p53-Independent Apoptosis Induced by Oncogenic Ras

1997 • 547 citations

A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

1988 • 532 citations

Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer

1999 • 512 citations

Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases.

1994 • 500 citations

Evidence that the G1-S and G2-M transitions are controlled by different cdc2 proteins in higher eukaryotes

1991 • 493 citations

Apoptosis and APC in colorectal tumorigenesis.

1996 • 491 citations

Sulindac Inhibits Activation of the NF-κB Pathway

1999 • 490 citations

The cyclooxygenase-2 inhibitor celecoxib is a potent preventive and therapeutic agent in the min mouse model of adenomatous polyposis.

2000 • 481 citations

The Nuclear Receptor PPARγ and Immunoregulation: PPARγ Mediates Inhibition of Helper T Cell Responses

2000 • 465 citations

Chemoprevention of colon cancer by specific cyclooxygenase-2 inhibitor, celecoxib, administered during different stages of carcinogenesis.

2000 • 462 citations

Etoricoxib (MK-0663): preclinical profile and comparison with other agents that selectively inhibit cyclooxygenase-2.

2001 • 450 citations

NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells.

1998 • 439 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis.

1996 • 421 citations

Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells.

1995 • 420 citations

Effect of Sodium Salicylate on the Human Heat Shock Response

1992 • 411 citations

Synergy between Interferon-γ and Tumor Necrosis Factor-α in Transcriptional Activation Is Mediated by Cooperation between Signal Transducer and Activator of Transcription 1 and Nuclear Factor κB

1997 • 410 citations

Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.

1995 • 400 citations

Prostacyclin-mediated activation of peroxisome proliferator-activated receptor δ in colorectal cancer

2000 • 396 citations

A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer’s disease

1999 • 393 citations

Cyclooxygenase Inhibitors Regulate the Expression of a TGF-β Superfamily Member That Has Proapoptotic and Antitumorigenic Activities

2001 • 389 citations

15-deoxy-Δ12,14-PGJ2 induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats

2000 • 381 citations

BREASTFEEDING IN DEVELOPING COUNTRIES

1981 • 374 citations

Glucocorticoid-mediated repression of nuclear factor-κBdependent transcription involves direct interference with transactivation

1997 • 371 citations

AP-1 and NF-kB Regulation in Rheumatoid Arthritis and Murine Collagen-Induced Arthritis

1998 • 367 citations

Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.

1997 • 362 citations

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 • 339 citations

Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability

1998 • 338 citations

Wnt-1 Regulates Free Pools of Catenins and Stabilizes APC-Catenin Complexes

1996 • 337 citations

Constitutive activation of IκB kinase α and NF-κB in prostate cancer cells is inhibited by ibuprofen

1999 • 315 citations

Salicylates inhibit I kappa B-alpha phosphorylation, endothelial-leukocyte adhesion molecule expression, and neutrophil transmigration.

1996 • 308 citations

Heat Shock Protein 70 Suppresses Astroglial-inducible Nitric-oxide Synthase Expression by Decreasing NFκB Activation

1996 • 294 citations

Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation

1997 • 282 citations

Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis

1999 • 280 citations

Malignant Transformation and Antineoplastic Actions of Nonsteroidal Antiinflammatory Drugs (Nsaids) on Cyclooxygenase-Null Embryo Fibroblasts

1999 • 269 citations

Apoptosis of T Cells Mediated by Ca ²⁺ -Induced Release of the Transcription Factor MEF2

1999 • 262 citations

Gene Expression (Collagenase, Tissue Inhibitor of Metalloproteinases, Complement, and HLA–DR) in Rheumatoid Arthritis and Osteoarthritis Synovium. Quantitative Analysis and Effect of Intraarticular Corticosteroids

1991 • 262 citations

Aspirin Inhibits Nuclear Factor–κB Mobilization and Monocyte Adhesion in Stimulated Human Endothelial Cells

1995 • 260 citations

The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells

2000 • 258 citations

Regulation of Fas-Ligand Expression during Activation-induced Cell Death in T Lymphocytes via Nuclear Factor κB

1999 • 257 citations

The effect of non-steroidal anti-inflammatory drugs on human colorectal cancer cells

2000 • 255 citations

Placental Transforming Growth Factor-β Is a Downstream Mediator of the Growth Arrest and Apoptotic Response of Tumor Cells to DNA Damage and p53 Overexpression

2000 • 248 citations

PTGF-β , a type β transforming growth factor (TGF-β) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-β signaling pathway

2000 • 244 citations

Activation-Dependent Transcriptional Regulation of the Human fas Promoter Requires NF-κB p50-p65 Recruitment

1999 • 232 citations

Interaction of the Immunosuppressant Deoxyspergualin with a Member of the Hsp70 Family of Heat Shock Proteins

1992 • 232 citations

The expression of matrix metalloproteinase 9 is enhanced by Epstein–Barr virus latent membrane protein 1

1998 • 230 citations

Glucocorticoids inhibit the induction of nitric oxide synthase II by down-regulating cytokine-induced activity of transcription factor nuclear factor-kappa B.

1996 • 228 citations

The major source of endogenous prostaglandin D2 production is likely antigen-presenting cells. Localization of glutathione-requiring prostaglandin D synthetase in histiocytes, dendritic, and Kupffer cells in various rat tissues.

1989 • 221 citations

Modes of action of aspirin-like drugs.

1985 • 218 citations

NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, EICOSANOIDS, AND COLORECTAL CANCER PREVENTION

1996 • 212 citations

Gastrin is a target of the β-catenin/TCF-4 growth-signaling pathway in a model of intestinal polyposis

2000 • 200 citations

Activation of p38 Mitogen-Activated Protein Kinase by Sodium Salicylate Leads to Inhibition of Tumor Necrosis Factor-Induced IκBα Phosphorylation and Degradation

1998 • 196 citations

Aspirin‐induced activation of the NF‐κB signaling pathway: a novel mechanism for aspirin‐mediated apoptosis in colon cancer cells

2001 • 188 citations

The NF-κB/Rel family of proteins mediates Aβ-induced neurotoxicity and glial activation

1998 • 187 citations

Differential Effects of Aspirin and Non-Aspirin Nonsteroidal Antiinflammatory Drugs in the Primary Prevention of Myocardial Infarction in Postmenopausal Women

2000 • 186 citations

Modes of action of aspirin-like drugs: Salicylates inhibit Erk activation and integrin-dependent neutrophil adhesion

1998 • 185 citations

Expression of a constitutive NF-kappa B-like activity is essential for proliferation of cultured bovine vascular smooth muscle cells.

1995 • 184 citations

Influence of J series prostaglandins on apoptosis and tumorigenesis of breast cancer cells

1999 • 183 citations

Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFκB

1999 • 181 citations

Identification of a novel member of the TGF-beta superfamily highly expressed in human placenta

1997 • 181 citations

Inhibition of Activator Protein 1 Activity and Neoplastic Transformation by Aspirin

1997 • 174 citations

Cyclooxygenase and inflammation in Alzheimer's disease: Experimental approaches and clinical interventions

1998 • 167 citations

NFκB Mediates Apoptosis through Transcriptional Activation of Fas (CD95) in Adenoviral Hepatitis

2000 • 165 citations

E-7869 (R-flurbiprofen) inhibits progression of prostate cancer in the TRAMP mouse.

2000 • 162 citations

Peroxisome proliferator-activated receptor gamma agonists protect cerebellar granule cells from cytokine-induced apoptotic cell death by inhibition of inducible nitric oxide synthase

1999 • 156 citations

Celecoxib loses its anti‐inflammatory efficacy at high doses through activation of NF‐κB

2001 • 152 citations

The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: alterations in tumor suppressor and cell cycle-regulatory proteins.

1996 • 151 citations

Transcriptional Induction of Multiple Cytokines by Human Respiratory Syncytial Virus Requires Activation of NF-κB and Is Inhibited by Sodium Salicylate and Aspirin

1997 • 146 citations

Inhibition of Ultraviolet B-induced Activator Protein-1 (AP-1) Activity by Aspirin in AP-1-Luciferase Transgenic Mice

1997 • 146 citations

Overexpression of the wild-type p53 gene inhibits NF-κB activity and synergizes with aspirin to induce apoptosis in human colon cancer cells

2000 • 141 citations

Cytokine induction of NO synthase II in human DLD‐1 cells: roles of the JAK‐STAT, AP‐1 and NF‐κB‐signaling pathways

1998 • 140 citations

Sodium Salicylate Activates Caspases and Induces Apoptosis of Myeloid Leukemia Cell Lines

1999 • 135 citations

NON-STEROIDAL ANTI-INFLAMMATORY DRUGS INHIBIT THE EXPRESSION OF CYTOKINES AND INDUCE HSP70 IN HUMAN MONOCYTES

1999 • 126 citations

Aspirin prevents tumors in a murine model of familial adenomatous polyposis

1998 • 124 citations

Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells

1998 • 121 citations

Role of the IκB Kinase Complex in Oncogenic Ras- and Raf-Mediated Transformation of Rat Liver Epithelial Cells

2000 • 121 citations

Induction of cytokines and ICAM-1 by proinflammatory cytokines in primary rheumatoid synovial fibroblasts and inhibition by N-acetyl-L-cysteine and aspirin

1996 • 121 citations

15-Deoxy-Δ12,14-prostaglandin J2, a Ligand for Peroxisome Proliferator-Activated Receptor-γ, Induces Apoptosis in JEG3 Choriocarcinoma Cells

1999 • 119 citations

Nonsteroidal Anti-Inflammatory Drug Use and Alzheimer's Disease: A Case-Control Study in Rochester, Minnesota, 1980 Through 1984

1998 • 113 citations

Drug-Induced Neuroprotection From Global Ischemia Is Associated With Prevention of Persistent but Not Transient Activation of Nuclear Factor-κB in Rats

1998 • 113 citations

Inhibition of Vascular Smooth Muscle Cell Proliferation by Sodium Salicylate Mediated by Upregulation of p21 ^Waf1 and p27 ^Kip1

2000 • 110 citations

Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice

2000 • 109 citations

Salicylate Triggers Heat Shock Factor Differently than Heat

1995 • 108 citations

Aspirin inhibits tumor cell invasiveness induced by Epstein-Barr virus latent membrane protein 1 through suppression of matrix metalloproteinase-9 expression.

2000 • 106 citations

Inhibition of the interferon-gamma/signal transducers and activators of transcription (STAT) pathway by hypermethylation at a STAT-binding site in the p21WAF1 promoter region.

2000 • 102 citations

The Extracellular Signal-regulated Kinase Pathway Is Required for Activation-induced Cell Death of T Cells

1999 • 99 citations

Human whole blood assays for inhibition of prostaglandin G/H synthases-1 and-2 using A23187 and lipopolysaccharide stimulation of thromboxane B2 production

1996 • 98 citations

R-flurbiprofen chemoprevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer.

1997 • 97 citations

Inhibition of Tumor Necrosis Factor-induced p42/p44 Mitogen-Activated Protein Kinase Activation by Sodium Salicylate

1996 • 89 citations

Salicylates inhibit lipopolysaccharide-induced transcriptional activation of the tissue factor gene in human monocytic cells

1995 • 89 citations

NSAIDs and butyrate sensitize a human colorectal cancer cell line to TNF-α and Fas ligation: the role of reactive oxygen species

1999 • 88 citations

Ex vivo assay to determine the cyclooxygenase selectivity of non‐steroidal anti‐inflammatory drugs

1999 • 88 citations

Regulation of FasL by NF-κB and AP-1 in Fas-dependent Thymineless Death of Human Colon Carcinoma Cells

2000 • 85 citations

Effects of ibuprofen enantiomers and its coenzyme A thioesters on human prostaglandin endoperoxide synthases

1997 • 85 citations

Cyclooxygenase‐independent inhibition of dendritic cell maturation by aspirin

2000 • 83 citations

Salicylate-induced Growth Arrest Is Associated with Inhibition of p70s6k and Down-regulation of c-Myc, Cyclin D1, Cyclin A, and Proliferating Cell Nuclear Antigen

2000 • 83 citations

Salicylates Inhibit NF-κB Activation and Enhance TNF-α-Induced Apoptosis in Human Pancreatic Cancer Cells

1999 • 82 citations

Comparative analysis of cathepsin l, cathepsin d, and collagenase messenger rna expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization

1995 • 81 citations

Regulation of T helper type 2 cell immunity by interleukin-4 and interleukin-13

2000 • 81 citations

Aspirin Inhibits Tumor Necrosis Factor-α Gene Expression in Murine Tissue Macrophages

1997 • 81 citations

Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis

1998 • 76 citations

STAT1 activation during monocyte to macrophage maturation: role of adhesion molecules

1999 • 76 citations

Comparative analgesic and anti‐inflammatory properties of sodium salicylate and acetylsalicylic acid (aspirin) in rheumatoid arthritis.

1989 • 74 citations

Ibuprofen: new explanation for an old phenomenon

1999 • 73 citations

Selective inhibition of interleukin-4 gene expression in human T cells by aspirin

2001 • 71 citations

NF-κB-dependent Fas ligand expression

1999 • 71 citations

4‐trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2‐hydroxy‐4‐trifluoromethylbenzoic acid, are potent inhibitors of nuclear factor κB activation

1999 • 69 citations

Intranuclear targeted delivery of functional NF-kappa B by 70kDa heatshock protein

1999 • 68 citations

Salicylic acid and aspirin inhibit the activity of RSK2 kinase and repress RSK2-dependent transcription of cyclic AMP response element binding protein- and NF-kappa B-responsive genes.

1999 • 64 citations

Nur77 transcription activity correlates with its apoptotic functionin vivo

1999 • 61 citations

Sodium salicylate inhibits proliferation and induces G1 cell cycle arrest in human pancreatic cancer cell lines

2000 • 61 citations

Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-γ is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1

2000 • 58 citations

Requirements for Triggering of Adipocyte Differentiation by Glucocorticoids and Indomethacin*

1987 • 55 citations

Antiproliferative Effects of the Enantiomers of Flurbiprofen

1996 • 54 citations

Cell-type-specific activation of c-Jun N-terminal kinase by salicylates

1999 • 53 citations

Aspirin inhibits inducible nitric oxide synthase expression and tumour necrosis factor‐α release by cultured smooth muscle cells

1999 • 51 citations

Elucidating the Mechanism of Action of the Immunosuppressant 15-Deoxyspergualin

1995 • 48 citations

Inhibition of NF‐KB and AP‐1 activation by R‐ and S‐flurbiprofen ^{1 , 2}

2001 • 48 citations

Adipogenesis in a myeloid supporting bone marrow stromal cell line

1992 • 47 citations

Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells

1997 • 47 citations

Salicylic Acid and Aspirin Inhibit the Activity of RSK2 Kinase and Repress RSK2-Dependent Transcription of Cyclic AMP Response Element Binding Protein- and NF-κB-Responsive Genes

1999 • 47 citations

Inhibition of Noxious Stimulus‐Induced Spinal Prostaglandin E₂ Release by Flurbiprofen Enantiomers

2000 • 46 citations

15-deoxy-Δ12,14 prostaglandin J2: A putative endogenous promoter of adipogenesis suppresses the ob gene

1999 • 45 citations

Suppressive Effects of Anti-inflammatory Agents on Human Endothelial Cell Activation and Induction of Heat Shock Proteins

1999 • 45 citations

Antinociceptive actions of R(−)-flurbiprofen - a non-cyclooxygenase inhibiting 2-arylpropionic acid - in rats

1994 • 44 citations

Peroxisome proliferator‐activated receptors are expressed in mouse bone marrow‐derived mast cells

2000 • 44 citations

Recent aspirin use is associated with smaller myocardial infarct size and lower likelihood of Q-wave infarction

1999 • 32 citations

Pharmacologic Management of Alzheimer Disease Part III: Nonsteroidal Antiinflammatory Drugs — Emerging Protective Evidence?

1999 • 31 citations

Sulindac and a cyclooxygenase-2 inhibitor, etodolac, increase APC mRNA in the colon of rats treated with azoxymethane

2000 • 30 citations

Aurothioglucose inhibits induced NF-kB and AP-1 activity by acting as an IL-1 functional antagonist

1992 • 29 citations

Chemokine gene expression in bone marrow stromal cells: downregulation with sodium salicylate

1995 • 29 citations

Stimulation of FcγR receptors induces monocyte chemoattractant protein-1 in the human monocytic cell line THP-1 by a mechanism involving IκB-α degradation and formation of p50/p65 NF-κB/Rel complexes

2000 • 28 citations

Stimulation of adipose differentiation related protein (ADRP) expression by ibuprofen and indomethacin in adipocyte precursors and in adipocytes

1998 • 28 citations

RSK2 represses HSF1 activation during heat shock

2000 • 26 citations

Activation of NF-.KAPPA.B Determines the Sensitivity of Human Colon Cancer Cells to TNF.ALPHA.-Induced Apoptosis.

2000 • 26 citations

A major metabolite of aceclofenac, 4′-hydroxy aceclofenac, suppresses the production of interstitial pro-collagenase/proMMP-1 and pro-stromelysin-1/proMMP-3 by human rheumatoid synovial cells

2000 • 25 citations

Differentiation Method-Dependent Expression of Leptin in Adipocyte Cell Lines

1998 • 24 citations

Inhibition of Cytokine Gene Expression by Sodium Salicylate in a Macrophage Cell Line through an NF-κB-Independent Mechanism

1999 • 23 citations

Transcriptional Induction of Nur77 by Indomethacin That Results in Apoptosis of Colon Cancer Cells.

2000 • 23 citations

Salutary effects of aspirin in coronary artery disease are not limited to its platelet inhibitory effects

1998 • 20 citations

Antiinflammatory action of salicylates: aspirin is not a prodrug for salicylate against rat carrageenin pleurisy

1989 • 18 citations

Salicylate-enhanced activation of transcription factors induced by interferon-γ

1999 • 17 citations

Does the acetyl group of aspirin contribute to the antiinflammatory efficacy of salicylic acid in the treatment of rheumatoid arthritis?

1990 • 17 citations

Aspirin in the treatment of juvenile arthritis

1983 • 16 citations

Induction of Apoptosis with I-kappa B, the Inhibitor of NF-kappa B

1999 • 14 citations

The Effects of & Newly Developed Nonsteroidal Anti-inflammatory Drug (M-5011) on Arachidonic Acid Metabolism in Rheumatoid Synovial Fibroblasts

1997 • 10 citations

Inhibition of the growth of 12V-ras-transformed rat fibroblasts by acetylsalicylic acid correlates with inhibition of NF-KB

1997 • 10 citations

Aspirin in the prevention of strokes

1999 • 9 citations

Clonogenic Inactivation of Colon Cancer-derived Cells Treated with 5-Fluorouracil and Indomethacin in Hybrid Spheroids

1998 • 7 citations

Salicylate-enhanced activation of transcription factors induced by interferon-γ

1999 • 5 citations

Deleted Work

1955 • 0 citations