Downregulation of β-catenin by human Axin and its association with the APC tumor suppressor, β-catenin and GSK3β

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

1997 • 3,847 citations

Identification and characterization of the familial adenomatous polyposis coli gene

1991 • 2,806 citations

Wnt signaling: a common theme in animal development

1997 • 2,579 citations

Identification of FAP Locus Genes from Chromosome 5q21

1991 • 2,358 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Association of the APC Gene Product with β-Catenin

1993 • 1,215 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.

1996 • 1,156 citations

Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein.

1995 • 1,025 citations

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1992 • 929 citations

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

1997 • 908 citations

Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female mice

1988 • 745 citations

Wnt Signaling and an APC-Related Gene Specify Endoderm in Early C. elegans Embryos

1997 • 663 citations

Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients.

1992 • 562 citations

Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

1995 • 492 citations

The adenomatous polyposis coli (APC) tumor suppressor

1997 • 446 citations

wingless signal and Zeste-white 3 kinase trigger opposing changes in the intracellular distribution of Armadillo

1994 • 423 citations

Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

1994 • 407 citations

The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

1994 • 406 citations

Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin

1994 • 405 citations

Wnt-1 Regulates Free Pools of Catenins and Stabilizes APC-Catenin Complexes

1996 • 337 citations

Components of wingless signalling in Drosophila

1994 • 326 citations

Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer.

1992 • 237 citations

Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3

1995 • 233 citations

Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene.

1997 • 225 citations

Mutations in the APC gene and their implications for protein structure and function

1995 • 188 citations

Alteration of beta-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients.

1996 • 174 citations

Adenomatous Polyposis Coli Tumor Suppressor Protein Has Signaling Activity in Xenopus laevis Embryos Resulting in the Induction of an Ectopic Dorsoanterior Axis

1997 • 108 citations

A Soluble Form of Wnt-1 Protein with Mitogenic Activity on Mammary Epithelial Cells

1995 • 83 citations

The adenomatous polyposis coli gene and human cancers

1995 • 24 citations

Deleted Work

1955 • 0 citations