Loss-of-Function Mutations in PPARγ Associated with Human Colon Cancer

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

1998 • 3,517 citations

15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

1995 • 2,857 citations

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

1997 • 2,063 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-γ

1998 • 1,902 citations

Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

1998 • 1,819 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

PPAR-gamma: adipogenic regulator and thiazolidinedione receptor.

1998 • 1,728 citations

Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

1996 • 1,033 citations

Differentiation and reversal of malignant changes in colon cancer through PPARγ

1998 • 984 citations

Terminal Differentiation of Human Breast Cancer through PPARγ

1998 • 844 citations

Ligands for peroxisome proliferator-activated receptorγ and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice

1998 • 807 citations

Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation

1998 • 652 citations

Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice

1998 • 612 citations

Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.

1998 • 599 citations

Activators of the nuclear receptor PPARγ enhance colon polyp formation

1998 • 585 citations

Obesity Associated with a Mutation in a Genetic Regulator of Adipocyte Differentiation

1998 • 549 citations

Transcriptional Activation by Peroxisome Proliferator-activated Receptor γ Is Inhibited by Phosphorylation at a Consensus Mitogen-activated Protein Kinase Site

1997 • 544 citations

Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-γ ligand troglitazone in patients with liposarcoma

1999 • 501 citations

RET Proto-Oncogene in the Development of Human Cancer

1999 • 333 citations

Activation of PPARγ leads to inhibition of anchorage-independent growth of human colorectal cancer cells

1998 • 319 citations

Modeling stochastic gene expression: Implications for haploinsufficiency

1998 • 244 citations

Signaling pathways in Ras-mediated tumorigenicity and metastasis

1998 • 194 citations

Allelic imbalance, including deletion ofPTEN/MMAC1, at the Cowden disease locus on 10q22-23, in hamartomas from patients with cowden syndrome and germlinePTEN mutation

1998 • 97 citations